Itraconazole

Generic Name
Itraconazole
Brand Names
Sporanox, Tolsura
Drug Type
Small Molecule
Chemical Formula
C35H38Cl2N8O4
CAS Number
84625-61-6
Unique Ingredient Identifier
304NUG5GF4
Background

One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.

Indication

For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.

Associated Conditions
Aspergillosis, Blastomycosis, Chromoblastomycosis, Coccidioidal meningitis, Esophageal Candidiasis, Fungal Infections, Fungal skin infection, Histoplasmosis, Onychomycosis, Oropharyngeal Candidiasis, Paracoccidioidomycosis, Penicillium marneffei infection, Pulmonary coccidioides, Sporotrichosis, Vulvovaginal Candidiasis, Disseminated Other specified protozoal diseases
Associated Therapies
-
Clinical Trials
Related News

A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat (IW-1701), in Healthy Volunteers

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: Olinciguat
Drug: Itraconazole
First Posted Date
2019-03-27
Last Posted Date
2019-07-15
Lead Sponsor
Cyclerion Therapeutics
Target Recruit Count
24
Registration Number
NCT03892499
Locations
🇺🇸

PPD, Austin, Texas, United States

A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 1291583 in the Blood

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: BI 1291583
Drug: Itraconazole
First Posted Date
2019-03-26
Last Posted Date
2021-11-11
Lead Sponsor
Boehringer Ingelheim
Target Recruit Count
14
Registration Number
NCT03890887
Locations
🇩🇪

CRS Clinical Research Services Mannheim GmbH, Mannheim, Germany

A Phase 1 Study to Assess the Pharmacokinetics of AZD9977 Administered Alone and in Combination With Itraconazole in Healthy Volunteers

First Posted Date
2019-02-15
Last Posted Date
2019-04-22
Lead Sponsor
AstraZeneca
Target Recruit Count
14
Registration Number
NCT03843060
Locations
🇺🇸

Research Site, Baltimore, Maryland, United States

A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 1358894 in the Blood

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: BI 1358894
Drug: Itraconazole
First Posted Date
2019-02-15
Last Posted Date
2021-11-17
Lead Sponsor
Boehringer Ingelheim
Target Recruit Count
16
Registration Number
NCT03843151
Locations
🇩🇪

CRS Clinical Research Services Berlin GmbH, Berlin, Germany

An Interaction Study of LY3200882 in Healthy Participants

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: LY3200882
Drug: Itraconazole
First Posted Date
2019-01-03
Last Posted Date
2019-03-08
Lead Sponsor
Eli Lilly and Company
Target Recruit Count
23
Registration Number
NCT03792139
Locations
🇺🇸

Covance Clinical Research Inc, Daytona Beach, Florida, United States

Study to Learn More About the Effect of Itraconazole (ITZ) Given Repeatedly by Mouth on the Way How the Study Drug BAY1902607 Given One Time by Mouth Acts in the Human Body of Healthy Male Participants

Phase 1
Completed
Conditions
Drug Interactions
Interventions
Drug: BAY1902607
Drug: Itraconazole
First Posted Date
2018-12-31
Last Posted Date
2019-05-29
Lead Sponsor
Bayer
Target Recruit Count
14
Registration Number
NCT03789890
Locations
🇩🇪

CRS Clinical Research Services Berlin GmbH, Berlin, Germany

A Study to Learn About the Drug-drug Interactions of Sisunatovir in Healthy Adult Participants

First Posted Date
2018-12-20
Last Posted Date
2024-04-22
Lead Sponsor
Pfizer
Target Recruit Count
82
Registration Number
NCT03782662
Locations
🇬🇧

Richmond Pharmacology Ltd, London, United Kingdom

A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 730357 in the Blood

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: BI 730357
Drug: Itraconazole
First Posted Date
2018-12-20
Last Posted Date
2023-07-12
Lead Sponsor
Boehringer Ingelheim
Target Recruit Count
14
Registration Number
NCT03782987
Locations
🇩🇪

Humanpharmakologisches Zentrum Biberach, Biberach, Germany

A Study to Investigate the Effect of CYP3A Inhibition on the Pharmacokinetics of RO7017773 in Healthy Participants

Phase 1
Completed
Conditions
Healthy Volunteers
Interventions
Drug: RO7017773
Drug: Itraconazole
First Posted Date
2018-12-13
Last Posted Date
2020-05-07
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
14
Registration Number
NCT03774576
Locations
🇫🇷

BIOTRIAL, Rennes, France

Drug-Drug Interaction Study Between EDP-938, Itraconazole, Rifampin, and Quinidine in Healthy Subjects

First Posted Date
2018-11-28
Last Posted Date
2019-06-14
Lead Sponsor
Enanta Pharmaceuticals, Inc
Target Recruit Count
72
Registration Number
NCT03755778
Locations
🇺🇸

Pharmaceutical Research Associates, Inc.,, Lenexa, Kansas, United States

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