Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in October, 2015 (irinotecan liposome injection, trade name Onivyde).
For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin). Also used in combination with cisplatin for the treatment of extensive small cell lung cancer. Irinotecan is currently under investigation for the treatment of metastatic or recurrent cervical cancer. Also used in combination with fluorouracil and leucovorin for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy.
University of Nebraska Medical Center, Omaha, Nebraska, United States
Mayo Clinic in Arizona, Scottsdale, Arizona, United States
USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States
MedStar Georgetown University Hospital, Washington, District of Columbia, United States
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
Moffitt Cancer Center, Tampa, Florida, United States
Department of Pancreatic and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center; Pancreatic Cancer Institute, Fudan University, Shanghai, Shanghai, China
Ac Medical Inc., Chuo Ku, Tokyo, Japan
Los Angeles County-USC Medical Center, Los Angeles, California, United States
Greater Baltimore Medical Center, Baltimore, Maryland, United States
Sinai Hospital of Baltimore, Baltimore, Maryland, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California, United States
UC Davis Comprehensive Cancer Center, Sacramento, California, United States
Istituto Ospedaliero Fondazione Poliambulanza, Brescia, Italy
Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy
AUSL/IRCCS di Reggio Emilia, Reggio Emilia, Italy
Mayo Clinic, Rochester, Minnesota, United States
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.