Sulfamethoxazole

Generic Name: Sulfamethoxazole

Brand Names: Bactrim, Septra, Sulfatrim

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₁N_₃O_₃S

CAS Number: 723-46-6

Unique Ingredient Identifier: JE42381TNV

Background: Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with trimethoprim, which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps in the biosynthesis of nucleic acids and pr...

Indication: Sulfamethoxazole is indicated in combination with trimethoprim, in various formulations, for the following infections caused by bacteria with documented susceptibility: urinary tract infections, acute otitis media in pediatric patients (when clinically indicated), acute exacerbations of chronic bronchitis in adults, enteritis caused by susceptible Shigella, ...

Associated Conditions: Acute Exacerbation of Chronic Bronchitis (AECB) caused by susceptible bacteria, Acute Otitis Media caused by susceptible bacteria, Brucellosis, Dysentery, Bacillary, Nocardiosis, Pneumocystis Jirovecii Pneumonia, Urinary Tract Infection caused by susceptible bacteria, Susceptible Cholera, Susceptible Enteritis infectious caused by Shigella flexneri, Susceptible Enteritis infectious caused by Shigella sonnei, Susceptible Travelers' Diarrhea caused by Enterotoxigenic E. Coli (ETEC) Infection

Associated Therapies: -

Clinical Trials

Steroid Withdrawal in Pediatric Kidney Transplant Recipients

Phase 2

Terminated

Conditions: End-Stage Renal Disease

Interventions: Drug: Basiliximab
Drug: Cyclosporine
Drug: Tacrolimus
Drug: Sirolimus
Drug: Methylprednisolone
Drug: Prednisone
Drug: Bactrim

First Posted Date: 2001-08-31

Last Posted Date: 2016-10-21

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 274

Registration Number: NCT00023244

Locations: 🇺🇸
University of Florida Health Science Center, Jacksonville, Florida, United States
🇺🇸
The Children's Hospital of Buffalo, Buffalo, New York, United States
🇺🇸
Westchester Medical Center, Valhalla, New York, United States

and more 16 locations

A Randomized, Double-Blind, Placebo Controlled Study of l-Leucovorin in Combination With Trimethoprim / Sulfamethoxazole in the Therapy of Pneumocystis Carinii Pneumonia in Patients With the Acquired Immunodeficiency Syndrome

Not Applicable

Completed

Conditions: Pneumonia, Pneumocystis Carinii
HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2005-06-24

Lead Sponsor: Lederle Laboratories

Registration Number: NCT00002002

Locations: 🇺🇸
San Francisco Gen Hosp, San Francisco, California, United States

A Comparison of Dapsone and Trimethoprim-Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS

Not Applicable

Completed

Conditions: Pneumonia, Pneumocystis Carinii
HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2005-06-24

Lead Sponsor: Jacobus Pharmaceutical

Registration Number: NCT00002283

Locations: 🇺🇸
Jacobus Pharmaceutical Co, Princeton, New Jersey, United States

Islet Transplantation for Type 1 Diabetes

Phase 2

Completed

Conditions: Diabetes Mellitus, Insulin-Dependent

Interventions: Procedure: Islet Transplantation
Drug: Sirolimus
Drug: Tacrolimus
Drug: Daclizumab
Drug: Sulfamethoxazole
Drug: Ganciclovir
Drug: Trimethoprim
Drug: Pentamidine

First Posted Date: 2001-08-31

Last Posted Date: 2017-03-15

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 36

Registration Number: NCT00014911

Locations: 🇩🇪
Justus-Leibig University, Giessen, Germany
🇨🇦
University of Alberta, Edmonton, Alberta, Canada
🇨🇭
University of Geneva, Geneva, Switzerland

and more 6 locations