Indocyanine green acid form

Generic Name: Indocyanine green acid form

Brand Names: Ic-green

Drug Type: Small Molecule

Chemical Formula: C_₄₃H_₄₈N_₂O_₆S_₂

CAS Number: 28782-33-4

Unique Ingredient Identifier: C4V974V932

Background: Indocyanine Green is a water soluble, tricarbocyanine dye with a peak spectral absorption at 800 nm. The chemical name for Indocyanine Green is 1 H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e] indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-,hydroxide, inner salt, sodium salt. Indocyanine Green for Injection USP has a pH of approximately 6.5 when reconstituted. Each vial of Indocyanine Green for Injection USP contains 25 mg of Indocyanine Green as a sterile lyophilized powder with no more than 5% sodium iodide.

Indication: For Determining Cardiac Output, Hepatic Function and Liver Blood Flow

For ophthalmic angiography

Clinical Trials

Lymphatic Occlusion Pressure in Lower Limb

Early Phase 1

Conditions: Lymphatic Function

Interventions: Drug: Indocyanine Green

First Posted Date: 2015-04-01

Last Posted Date: 2015-04-01

Lead Sponsor: Centre Hospitalier Universitaire Saint Pierre

Target Recruit Count: 32

Registration Number: NCT02405559

Locations: 🇧🇪
CHU St-Pierre - Lymphology Clinic of Brussels, Brussels, Belgium

Determining Occlusion Pressure in Lymphatic Vessels

Early Phase 1

Completed

Conditions: Determination of the Occlusion Pressure in Lymphatic Vessels

Interventions: Drug: Indocyanine Green

First Posted Date: 2015-02-10

Last Posted Date: 2015-02-13

Lead Sponsor: Centre Hospitalier Universitaire Saint Pierre

Target Recruit Count: 32

Registration Number: NCT02359578

Locations: 🇧🇪
CHU St-Pierre, Brussels, Belgium

Fluorescence Cholangiography During Cholecystectomy - a RCT

Not Applicable

Completed

Conditions: Gallstones
Cholecystitis

Interventions: Drug: Indocyanine green
Drug: Urografin
Device: Near-infrared illumination
Radiation: X-ray

First Posted Date: 2015-01-26

Last Posted Date: 2024-02-28

Lead Sponsor: Hvidovre University Hospital

Target Recruit Count: 120

Registration Number: NCT02344654

Study Assessing The Interest of Indocyanine Green Fluorescence Imaging With Radioisotope Method For Sentinel Lymph Node Biopsy in Patients With Breast Cancer

Phase 3

Completed

Conditions: Breast Neoplasms

Interventions: Drug: isotope
Drug: indocyanine green

First Posted Date: 2014-10-30

Last Posted Date: 2018-04-09

Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Target Recruit Count: 99

Registration Number: NCT02279108

Locations: 🇫🇷
Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France

Fluorescence Surgery for Sentinel Node Identification in Melanoma

Not Applicable

Conditions: Melanoma
Lymph Node Metastasis

Interventions: Procedure: Near infra red sentinel node biopsy
Drug: Indocyanine green
Device: Intraoperative Near-Infrared Imaging System

First Posted Date: 2014-05-20

Last Posted Date: 2017-02-02

Lead Sponsor: Barretos Cancer Hospital

Target Recruit Count: 318

Registration Number: NCT02142244

Locations: 🇧🇷
Barretos Cancer Hospital, Barretos, SP, Brazil

Diffuse Optical Imaging With Indocyanine Green Solution in Imaging Pelvic Lymph Nodes in Patients With Stage II Prostate Cancer Undergoing Surgery

Phase 1

Completed

Conditions: Stage IIA Prostate Cancer
Stage IIB Prostate Cancer

Interventions: Drug: indocyanine green solution
Other: diffuse optical imaging
Procedure: robot-assisted laparoscopic surgery
Procedure: therapeutic lymphadenectomy