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Indocyanine green acid form

Generic Name
Indocyanine green acid form
Brand Names
Ic-green
Drug Type
Small Molecule
Chemical Formula
C43H48N2O6S2
CAS Number
28782-33-4
Unique Ingredient Identifier
C4V974V932
Background

Indocyanine Green is a water soluble, tricarbocyanine dye with a peak spectral absorption at 800 nm. The chemical name for Indocyanine Green is 1 H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e] indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-,hydroxide, inner salt, sodium salt. Indocyanine Green for Injection USP has a pH of approximately 6.5 when reconstituted. Each vial of Indocyanine Green for Injection USP contains 25 mg of Indocyanine Green as a sterile lyophilized powder with no more than 5% sodium iodide.

Indication

For Determining Cardiac Output, Hepatic Function and Liver Blood Flow

For ophthalmic angiography

Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery

Phase 3
Completed
Conditions
Endometrium Cancer
Ovary Cancer
Squamous Cell Carcinoma, Skin
Breast Carcinoma
Anus Cancer
Head and Neck Cancer
Melanoma (Skin)
Cervix Cancer
Vulva Cancer
Rectum Cancer
Interventions
Device: Optonuclear probe
Device: Quest Camera
First Posted Date
2016-12-20
Last Posted Date
2023-01-09
Lead Sponsor
Institut de Cancérologie de Lorraine
Target Recruit Count
744
Registration Number
NCT02997553
Locations
🇫🇷

Institut de Cancérologie de Lorraine, Vandoeuvre-les-Nancy, France

Axillary Reverse Mapping Using Near-infrared Imaging in Invasive Breast Cancer: Predictors of Nodal Positivity

Not Applicable
Completed
Conditions
Breast Cancer
Interventions
First Posted Date
2016-12-15
Last Posted Date
2022-05-16
Lead Sponsor
Gustave Roussy, Cancer Campus, Grand Paris
Target Recruit Count
120
Registration Number
NCT02994225
Locations
🇫🇷

Gustave Roussy, Villejuif, Val De Marne, France

Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor

Completed
Conditions
Traumatic Brain Injury
Acute Anoxic Encephalopathy
Ischemic Stroke
Intracerebral Hemorrhage
Subarachnoid Hemorrhage
Interventions
First Posted Date
2016-12-06
Last Posted Date
2022-09-02
Lead Sponsor
University of Pennsylvania
Target Recruit Count
29
Registration Number
NCT02983786
Locations
🇺🇸

University of Pennylvania Health System, Philadelphia, Pennsylvania, United States

Interest of Fluorescence in Salvage Surgery for Recurrence of Head and Neck Cancer in Irradiated Area

Not Applicable
Completed
Conditions
Head and Neck Cancer
Interventions
First Posted Date
2016-09-30
Last Posted Date
2022-03-31
Lead Sponsor
Institut de Cancérologie de Lorraine
Target Recruit Count
10
Registration Number
NCT02920216
Locations
🇫🇷

Institut de Cancérologie de Lorraine, Vandoeuvre-lès-Nancy, France

Role of Indocyanine Green (ICG) for Detection of Sentinel Nodes in Breast Cancer

Not Applicable
Completed
Conditions
Breast Cancer
Interventions
First Posted Date
2016-08-23
Last Posted Date
2019-07-05
Lead Sponsor
Association Pour La Recherche des Thérapeutiques Innovantes en Cancérologie
Target Recruit Count
80
Registration Number
NCT02875626
Locations
🇫🇷

Hôpital Européen Georges Pompidou, Paris, France

Solid Tumor Cancer Surgery With or Without Intraoperative Imaging: A Registry

Completed
Conditions
Bladder Cancer
Gastric Cancer
First Posted Date
2016-08-02
Last Posted Date
2021-06-18
Lead Sponsor
University of Pennsylvania
Target Recruit Count
291
Registration Number
NCT02852252
Locations
🇺🇸

Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States

Near Infrared Fluorescence Imaging With Indocyanine Green

Early Phase 1
Completed
Conditions
Solitary Pulmonary Nodules
Interventions
Device: near infrared fluorescence imaging (NIFI)
First Posted Date
2016-08-01
Last Posted Date
2017-11-21
Lead Sponsor
University of Pittsburgh
Target Recruit Count
25
Registration Number
NCT02851368
Locations
🇺🇸

Department of Cardiothoracic Surgery, Pittsburgh, Pennsylvania, United States

A Prospective Clinical Study for Evaluation of Safe Resection Margin in Breast Conserving Surgery in Breast Cancer

Phase 2
Conditions
Breast Cancer
Interventions
First Posted Date
2016-06-29
Last Posted Date
2016-06-29
Lead Sponsor
National Cancer Center, Korea
Target Recruit Count
149
Registration Number
NCT02817334
Locations
🇰🇷

National Cancer Center, Goyang-si, Gyeonggi-do, Korea, Republic of

Selective Lymph Node Dissection Using Fluorescent Dye in Node-positive Breast Cancer

Phase 4
Conditions
Breast Neoplasms
Interventions
Procedure: Axillary lymph node dissection
Device: Imaging devices
First Posted Date
2016-05-24
Last Posted Date
2016-09-20
Lead Sponsor
Samsung Medical Center
Target Recruit Count
150
Registration Number
NCT02781259
Locations
🇰🇷

Samsung medical center, Seoul, Korea, Republic of

Measurements of Kidney Perfusion After Transplantation by Intraoperative Fluorescence Angiography

Phase 2
Completed
Conditions
Kidney Transplantation
Interventions
First Posted Date
2016-05-18
Last Posted Date
2020-05-08
Lead Sponsor
University Hospital Erlangen
Target Recruit Count
128
Registration Number
NCT02775838
Locations
🇩🇪

University of Erlangen, Vascular Surgery, Erlangen, Germany

🇩🇪

University of Mannheim, General Surgery, Mannheim, Germany

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