Indocyanine green acid form

Generic Name: Indocyanine green acid form

Brand Names: Ic-green

Drug Type: Small Molecule

Chemical Formula: C_₄₃H_₄₈N_₂O_₆S_₂

CAS Number: 28782-33-4

Unique Ingredient Identifier: C4V974V932

Background: Indocyanine Green is a water soluble, tricarbocyanine dye with a peak spectral absorption at 800 nm. The chemical name for Indocyanine Green is 1 H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e] indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-,hydroxide, inner salt, sodium salt. Indocyanine Green for Injection USP has a pH of approximately 6.5 when reconstituted. Each vial of Indocyanine Green for Injection USP contains 25 mg of Indocyanine Green as a sterile lyophilized powder with no more than 5% sodium iodide.

Indication: For Determining Cardiac Output, Hepatic Function and Liver Blood Flow

For ophthalmic angiography

Clinical Trials

NIR Fluorescence Imaging of Lymphatic Transport Using ICG

Phase 1

Completed

Conditions: Rheumatoid Arthritis

Interventions: Drug: Indocyanine Green
Device: MultiSpectral Imaging System

First Posted Date: 2016-02-11

Last Posted Date: 2022-10-18

Lead Sponsor: University of Rochester

Target Recruit Count: 23

Registration Number: NCT02680067

Locations: 🇺🇸
University of Rochester, Rochester, New York, United States

The Impact of Indocyanine Green-enhanced Fluorescence Imaging on Bowel Transection in Left-sided Colorectal Resection

Not Applicable

Conditions: Anastomotic Leak

Interventions: Drug: indocyanine green
Device: Fluorescence imaging

First Posted Date: 2016-02-01

Last Posted Date: 2016-02-01

Lead Sponsor: The University of Hong Kong

Target Recruit Count: 30

Registration Number: NCT02669485

Locations: 🇭🇰
Queen Mary Hospital, Hong Kong, Hong Kong

Minimally Invasive Imagery With Indocyanine Green

Phase 1

Completed

Conditions: Neoplasms

Interventions: Drug: Indocyanine Green

First Posted Date: 2015-12-03

Last Posted Date: 2018-03-20

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 48

Registration Number: NCT02621268

Locations: 🇺🇸
Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States

NIR Fluorescence Imaging Technique in Thoracic Surgery With ICG

Phase 1

Completed

Conditions: Lung Cancer
Esophageal Cancer

Interventions: Drug: Indocyanine green

First Posted Date: 2015-11-20

Last Posted Date: 2018-06-08

Lead Sponsor: Chinese Academy of Sciences

Target Recruit Count: 36

Registration Number: NCT02611245

Locations: 🇨🇳
Key Laboratory of Molecular Imaging, Chinese Academy of Sciences, Beijing, Beijing, China

Near-Infrared Fluorescence Guided Robotic Pulmonary Segmentectomy for Early Stage Lung Cancer

Phase 1

Recruiting

Conditions: Non-small Cell Lung Cancer

Interventions: Drug: indocyanine green

First Posted Date: 2015-10-07

Last Posted Date: 2024-12-06

Lead Sponsor: St. Joseph's Healthcare Hamilton

Target Recruit Count: 250

Registration Number: NCT02570815

Locations: 🇨🇦
St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada

ENB Robotic ICG Guided Surgery: A Novel Technique for Targeting Small Lung Tumors

Phase 1

Withdrawn

Conditions: Non-small Cell Lung Cancer
Thoracic Surgery

Interventions: Drug: Indocyanine Green

First Posted Date: 2015-10-07

Last Posted Date: 2017-06-05

Lead Sponsor: St. Joseph's Healthcare Hamilton

Registration Number: NCT02570958

Clinical Application of Dual Sentinel Lymph Node Staining Method in Breast Cancer Patients

Phase 2

Completed

Conditions: Breast Cancer

Interventions: Drug: Indocyanine green
Drug: Radioisotope

First Posted Date: 2015-06-24

Last Posted Date: 2023-02-22

Lead Sponsor: National Cancer Center, Korea

Target Recruit Count: 130

Registration Number: NCT02479997

Locations: 🇰🇷
National Cancer Center, Goyang-si, Gyeonggi-do, Korea, Republic of

Clinical Application of Near-infrared Fluorescence Guided Localization on Breast Surgery in Breast Cancer

Phase 2

Conditions: Breast Cancer

Interventions: Drug: indocyanine green

First Posted Date: 2015-06-16

Last Posted Date: 2015-06-18

Lead Sponsor: National Cancer Center, Korea

Target Recruit Count: 5

Registration Number: NCT02473159

Locations: 🇰🇷
National Cancer Center, Goyang-si, Gyeonggi-do, Korea, Republic of

Comparison of Use of Indocyanine Green and 99mTc-labeled Radiotracer for Axillary Lymphatic Mapping in Patients With Breast Cancer

Not Applicable

Completed

Conditions: Stage I Breast Cancer
Stage II Breast Cancer

Interventions: Drug: Indocyanine Green Solution
Radiation: Technetium Tc-99m Sulfur Colloid
Procedure: Lymphoscintigraphy
Procedure: Axillary Lymph Node Biopsy