DeepMed Research

Indocyanine green acid form

Generic Name: Indocyanine green acid form

Brand Names: Ic-green

Drug Type: Small Molecule

Chemical Formula: C_₄₃H_₄₈N_₂O_₆S_₂

CAS Number: 28782-33-4

Unique Ingredient Identifier: C4V974V932

Background: Indocyanine Green is a water soluble, tricarbocyanine dye with a peak spectral absorption at 800 nm. The chemical name for Indocyanine Green is 1 H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e] indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-,hydroxide, inner salt, sodium salt. Indocyanine Green for Injection USP has a pH of approximately 6.5 when reconstituted. Each vial of Indocyanine Green for Injection USP contains 25 mg of Indocyanine Green as a sterile lyophilized powder with no more than 5% sodium iodide.

Indication: For Determining Cardiac Output, Hepatic Function and Liver Blood Flow

For ophthalmic angiography

Clinical Trials

TMVP1-ICG Mapping in Laparoscopic SLN Detection in Cervical Cancer

Phase 1

Conditions: Cervical Cancer

Interventions: Drug: TMVP1-ICG
Drug: ICG

First Posted Date: 2017-10-25

Last Posted Date: 2017-10-25

Lead Sponsor: Huazhong University of Science and Technology

Target Recruit Count: 40

Registration Number: NCT03320772

Locations: 🇨🇳
Tongji Hospital, Tongji Medical Colledge, HUST, Wuhan, Hubei, China

TMTP1-ICG Mapping in Laparoscopic SLN Detection in Cervical Cancer

Phase 1

Conditions: Cervical Cancer

Interventions: Drug: TMTP1-ICG
Drug: ICG

First Posted Date: 2017-10-25

Last Posted Date: 2017-10-27

Lead Sponsor: Huazhong University of Science and Technology

Target Recruit Count: 40

Registration Number: NCT03321448

Locations: 🇨🇳
Tongji Hospital, Tongji Medical Colledge, HUST, Wuhan, Hubei, China

SPY-X: A Study to Assess the Feasibility of Using SPY Alone for Sentinel Node Localization for Melanoma or Breast Cancer

Phase 3

Completed

Conditions: Sentinel Lymph Node
Melanoma (Skin)
Breast Cancer

Interventions: Drug: IC-Green KIT

First Posted Date: 2017-09-27

Last Posted Date: 2023-01-12

Lead Sponsor: Milton S. Hershey Medical Center

Target Recruit Count: 35

Registration Number: NCT03294330

Locations: 🇺🇸
Emory University Hospital, Atlanta, Georgia, United States
🇺🇸
PennState Health Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States
🇺🇸
Vassar Brothers Medical Center, Poughkeepsie, New York, United States

FLOTOR Pilot Study

Phase 1

Completed

Conditions: Chylothorax
Esophageal Cancer
Thoracic Duct Intra-Operative Injury

Interventions: Drug: Indocyanine Green

First Posted Date: 2017-09-26

Last Posted Date: 2018-11-19

Lead Sponsor: Oxford University Hospitals NHS Trust

Target Recruit Count: 21

Registration Number: NCT03292757

Locations: 🇬🇧
Department of Upper GI Surgery, Oxford University Hospitals, Headington, Oxfordshire, United Kingdom

Two-Part Study to Evaluate the Safety and Efficacy of Image Guided Surgery Using Indocyanine Green for Intramolecular Imaging of Nervous System Tumors Compared to Standard of Care, (TumorGlow)

Phase 1

Completed

Conditions: Brain Tumor, Primary
Brain Tumor, Recurrent

Interventions: Drug: Indocyanine Green

First Posted Date: 2017-08-25

Last Posted Date: 2020-08-14

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 363

Registration Number: NCT03262636

Fluorescence Targeted Pelvic Lymph Node Mapping

Phase 1

Terminated

Conditions: Cancer of Rectum
Lymph Node Disease

Interventions: Drug: Indocyanine Green

First Posted Date: 2017-07-02

Last Posted Date: 2019-08-13

Lead Sponsor: Oxford University Hospitals NHS Trust

Target Recruit Count: 1

Registration Number: NCT03204994

Locations: 🇬🇧
Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, United Kingdom

Validation of ICG to Identify the Urethra During Rectal Surgery

Phase 1

Terminated

Conditions: Urethra Injury
Rectal Cancer
Surgery

Interventions: Drug: Indocyanine Green Solution

First Posted Date: 2017-06-29

Last Posted Date: 2019-08-13

Lead Sponsor: Oxford University Hospitals NHS Trust

Target Recruit Count: 5

Registration Number: NCT03204201

Locations: 🇬🇧
Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, United Kingdom

Intraoperative ICG for Systemic Sclerosis

Phase 4

Withdrawn

Conditions: Systemic Sclerosis

Interventions: Procedure: Order of two elements of surgical procedure
Drug: Indocyanine Green

First Posted Date: 2017-05-16

Last Posted Date: 2020-06-30

Lead Sponsor: Duke University

Registration Number: NCT03155464

Estimation of Vascularization After Treatment of Deep Rectovaginal Endometriosis Node by Rectal Shaving

Phase 4

Conditions: Deep Endometriosis
Recto Vaginal Node

Interventions: Drug: Indocyanine green

First Posted Date: 2017-03-15

Last Posted Date: 2019-02-04

Lead Sponsor: University Hospital, Clermont-Ferrand

Target Recruit Count: 30

Registration Number: NCT03080558

Locations: 🇫🇷
CHU Clermont-Ferrand, Clermont-Ferrand, France

Angiosome Perfusion After Tibial Bypass

Phase 2

Completed

Conditions: Peripheral Arterial Disease

Interventions: Drug: Indocyanine Green

First Posted Date: 2017-01-06

Last Posted Date: 2017-01-06

Lead Sponsor: University Hospital Erlangen

Target Recruit Count: 40

Registration Number: NCT03012750

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