Indocyanine green acid form

Generic Name: Indocyanine green acid form

Brand Names: Ic-green

Drug Type: Small Molecule

Chemical Formula: C_₄₃H_₄₈N_₂O_₆S_₂

CAS Number: 28782-33-4

Unique Ingredient Identifier: C4V974V932

Background: Indocyanine Green is a water soluble, tricarbocyanine dye with a peak spectral absorption at 800 nm. The chemical name for Indocyanine Green is 1 H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e] indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-,hydroxide, inner salt, sodium salt. Indocyanine Green for Injection ...

Indication: For Determining Cardiac Output, Hepatic Function and Liver Blood Flow

For ophthalmic angiography

Associated Conditions: -

Associated Therapies: -

Clinical Trials

FLOTOR Pilot Study

Phase 1

Completed

Conditions: Chylothorax
Esophageal Cancer
Thoracic Duct Intra-Operative Injury

Interventions: Drug: Indocyanine Green

First Posted Date: 2017-09-26

Last Posted Date: 2018-11-19

Lead Sponsor: Oxford University Hospitals NHS Trust

Target Recruit Count: 21

Registration Number: NCT03292757

Locations: 🇬🇧
Department of Upper GI Surgery, Oxford University Hospitals, Headington, Oxfordshire, United Kingdom

Two-Part Study to Evaluate the Safety and Efficacy of Image Guided Surgery Using Indocyanine Green for Intramolecular Imaging of Nervous System Tumors Compared to Standard of Care, (TumorGlow)

Phase 1

Completed

Conditions: Brain Tumor, Primary
Brain Tumor, Recurrent

Interventions: Drug: Indocyanine Green

First Posted Date: 2017-08-25

Last Posted Date: 2020-08-14

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 363

Registration Number: NCT03262636

Fluorescence Targeted Pelvic Lymph Node Mapping

Phase 1

Terminated

Conditions: Cancer of Rectum
Lymph Node Disease

Interventions: Drug: Indocyanine Green

First Posted Date: 2017-07-02

Last Posted Date: 2019-08-13

Lead Sponsor: Oxford University Hospitals NHS Trust

Target Recruit Count: 1

Registration Number: NCT03204994

Locations: 🇬🇧
Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, United Kingdom

Intraoperative ICG for Systemic Sclerosis

Phase 4

Withdrawn

Conditions: Systemic Sclerosis

Interventions: Procedure: Order of two elements of surgical procedure
Drug: Indocyanine Green

First Posted Date: 2017-05-16

Last Posted Date: 2020-06-30

Lead Sponsor: Duke University

Registration Number: NCT03155464

Estimation of Vascularization After Treatment of Deep Rectovaginal Endometriosis Node by Rectal Shaving

Phase 4

Conditions: Deep Endometriosis
Recto Vaginal Node

Interventions: Drug: Indocyanine green

First Posted Date: 2017-03-15

Last Posted Date: 2019-02-04

Lead Sponsor: University Hospital, Clermont-Ferrand

Target Recruit Count: 30

Registration Number: NCT03080558

Locations: 🇫🇷
CHU Clermont-Ferrand, Clermont-Ferrand, France

Angiosome Perfusion After Tibial Bypass

Phase 2

Completed

Conditions: Peripheral Arterial Disease

Interventions: Drug: Indocyanine Green

First Posted Date: 2017-01-06

Last Posted Date: 2017-01-06

Lead Sponsor: University Hospital Erlangen

Target Recruit Count: 40

Registration Number: NCT03012750

Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery

Phase 3

Completed

Conditions: Endometrium Cancer
Ovary Cancer
Squamous Cell Carcinoma, Skin
Breast Carcinoma
Anus Cancer
Head and Neck Cancer
Melanoma (Skin)
Cervix Cancer
Vulva Cancer
Rectum Cancer

Interventions: Drug: Indocyanine green
Drug: Technetium99
Device: Optonuclear probe
Device: Quest Camera

First Posted Date: 2016-12-20

Last Posted Date: 2023-01-09

Lead Sponsor: Institut de Cancérologie de Lorraine

Target Recruit Count: 744

Registration Number: NCT02997553

Locations: 🇫🇷
Institut de Cancérologie de Lorraine, Vandoeuvre-les-Nancy, France

Axillary Reverse Mapping Using Near-infrared Imaging in Invasive Breast Cancer: Predictors of Nodal Positivity

Not Applicable

Completed

Conditions: Breast Cancer

Interventions: Drug: Indocyanine Green

First Posted Date: 2016-12-15

Last Posted Date: 2022-05-16

Lead Sponsor: Gustave Roussy, Cancer Campus, Grand Paris

Target Recruit Count: 120

Registration Number: NCT02994225

Locations: 🇫🇷
Gustave Roussy, Villejuif, Val De Marne, France

Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor

Completed

Conditions: Traumatic Brain Injury
Acute Anoxic Encephalopathy
Ischemic Stroke
Intracerebral Hemorrhage
Subarachnoid Hemorrhage

Interventions: Drug: Indocyanine Green

First Posted Date: 2016-12-06

Last Posted Date: 2022-09-02

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 29

Registration Number: NCT02983786

Locations: 🇺🇸
University of Pennylvania Health System, Philadelphia, Pennsylvania, United States

Interest of Fluorescence in Salvage Surgery for Recurrence of Head and Neck Cancer in Irradiated Area

Not Applicable

Completed

Conditions: Head and Neck Cancer

Interventions: Drug: indocyanine green

First Posted Date: 2016-09-30

Last Posted Date: 2022-03-31

Lead Sponsor: Institut de Cancérologie de Lorraine

Target Recruit Count: 10

Registration Number: NCT02920216

Locations: 🇫🇷
Institut de Cancérologie de Lorraine, Vandoeuvre-lès-Nancy, France

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