Acyclovir
- Generic Name
- Acyclovir
- Brand Names
- Sitavig, Xerese, Zovirax
- Drug Type
- Small Molecule
- Chemical Formula
- C8H11N5O3
- CAS Number
- 59277-89-3
- Unique Ingredient Identifier
- X4HES1O11F
- Background
Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old.
Acyclovir was granted FDA approval on 29 March 1982.
- Indication
An acyclovir topical cream is indicated to treat recurrent herpes labialis in immunocompetent patients 12 years and older. Acyclovir oral tablets, capsules, and suspensions are indicated to treat herpes zoster, genital herpes, and chickenpox. An acyclovir topical ointment is indicated to treat initial genital herpes and limited non-life-threatening mucocutaneous herpes simplex in immunocompromised patients. An acyclovir cream with hydrocortisone is indicated to treat recurrent herpes labialis, and shortening lesion healing time in patients 6 years and older. An acyclovir buccal tablet is indicated for the treatment of recurrent herpes labialis. An acyclovir ophthalmic ointment is indicated to treat acute herpetic keratitis.
- Associated Conditions
- Bell's Palsy, Chickenpox, Cytomegalovirus (CMV) Infections, Herpes Simplex Infections, Herpes Zoster, Herpes simplex encephalitis, Herpes simplex of the oral-labial, Herpes simplex type I reactivation, Recurrent Genital Herpes (RGH), Recurrent Herpes Labialis, VZV re-activation, Acute Genital herpes, Acute Herpes labialis, Acute Herpetic keratitis, Severe Genital herpes
Effect of Various Treatment Modalities on Dendritic Vial Ulcer
- Conditions
- Corneal Ulcer
- Interventions
- First Posted Date
- 2022-04-06
- Last Posted Date
- 2022-04-06
- Lead Sponsor
- Sohag University
- Target Recruit Count
- 40
- Registration Number
- NCT05313828
- Locations
- 🇪🇬
Sohag University, Sohag, Egypt
A Study to Compare Sitavig (Acyclovir) Buccal Tablet With a Placebo in the Treatment of Herpes Labialis in Participants Whose Immune System Works Normally
- Conditions
- Recurrent Herpes Labialis
- Interventions
- First Posted Date
- 2021-10-28
- Last Posted Date
- 2024-07-24
- Lead Sponsor
- Bayer
- Target Recruit Count
- 2019
- Registration Number
- NCT05098938
- Locations
- 🇺🇸
Science 37, Culver City, California, United States
Pharmacokinetic Properties of 200 and 400 mg Acyclovir Tablet in Indonesia Healthy Subject
- Conditions
- Drug Use
- Interventions
- First Posted Date
- 2021-08-03
- Last Posted Date
- 2023-02-09
- Lead Sponsor
- PT. Kimia Farma (Persero) Tbk
- Target Recruit Count
- 56
- Registration Number
- NCT04988646
- Locations
- 🇮🇩
PT Pharma Metric Labs, Jakarta Pusat, DKI Jakarta, Indonesia
The Effectiveness of Oral Acyclovir in the Treatment of Molluscum Contagiosum in Children
- First Posted Date
- 2020-07-20
- Last Posted Date
- 2020-07-20
- Lead Sponsor
- Dalia Mahran
- Target Recruit Count
- 35
- Registration Number
- NCT04476186
- Locations
- 🇪🇬
Hamdy Gomaa, Assiut, New Assiut City, Egypt
Optimized Antibiotic Therapy in Patients With Subarachnoid Haemorrhage (ES) and Cerebral Haemorrhage (EC)
- Conditions
- Therapeutic Drug MonitoringSubarachnoid HemorrhageIntracerebral Hemorrhage
- First Posted Date
- 2019-10-18
- Last Posted Date
- 2021-07-21
- Target Recruit Count
- 104
- Registration Number
- NCT04132115
- Locations
- 🇮🇹
Anesthesiology and Intensive Care Clinic - Department of Medicine - ASUIUD, Udine, Italy
🇮🇹Terapia Intensiva 1, Udine, Italy
Melatonin Effects on Genital Herpes in Brazilian Women
- Conditions
- Genital Herpes
- Interventions
- Combination Product: Melatonin 3 mg
- First Posted Date
- 2019-02-05
- Last Posted Date
- 2022-01-11
- Lead Sponsor
- University of Sao Paulo General Hospital
- Target Recruit Count
- 90
- Registration Number
- NCT03831165
- Locations
- 🇧🇷
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
🇧🇷Avenida Doutor Eneas Carvalho de Aguiar 255 10 andar, São Paulo, SP, Brazil
EBV Positive Nasopharyngeal Carcinoma Treated With Concurrent Chemo-radiotherapy With or Without Anti-Viral Drug
- Conditions
- Drug Use for Unapproved Schedule
- Interventions
- Combination Product: Radiotherapy and chemotherapy
- First Posted Date
- 2018-09-04
- Last Posted Date
- 2018-09-04
- Lead Sponsor
- Kuwait Cancer Control Center
- Target Recruit Count
- 50
- Registration Number
- NCT03656965
- Locations
- 🇰🇼
Kuwait Cancer Control Center, Kuwait, Kuwait
Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis
- Conditions
- Herpes Simplex Virus Keratitis
- Interventions
- First Posted Date
- 2018-08-13
- Last Posted Date
- 2022-01-14
- Lead Sponsor
- NYU Langone Health
- Registration Number
- NCT03626376
- Locations
- 🇺🇸
New York University School of Medicine, New York, New York, United States
Letermovir Versus Valganciclovir to Prevent Human Cytomegalovirus Disease in Kidney Transplant Recipients (MK-8228-002)
- Conditions
- CMV Disease
- Interventions
- Drug: Placebo to ACVDrug: Placebo to LETDrug: Placebo to VGCV
- First Posted Date
- 2018-02-23
- Last Posted Date
- 2023-07-28
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 601
- Registration Number
- NCT03443869
- Locations
- 🇺🇸
University of Chicago ( Site 0251), Chicago, Illinois, United States
🇺🇸Brigham & Women's Hospital ( Site 0244), Boston, Massachusetts, United States
🇺🇸The Ohio State University Wexner Medical Center ( Site 0264), Columbus, Ohio, United States
A Clinical Trial of Acyclovir for Viral Uveitis
- First Posted Date
- 2018-01-03
- Last Posted Date
- 2021-04-05
- Lead Sponsor
- Xiaomin Zhang
- Target Recruit Count
- 30
- Registration Number
- NCT03389191
- Locations
- 🇨🇳
Tianjin Medical University Eye Hospital, Tianjin, Tianjin, China
Drug Development Updates
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