Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Effects of Anesthetic Infusion on the Amplitude of Motor Evoked Potential in Pediatrics Undergoing Tethered Spinal Cord Surgeries

Phase 1

Completed

Conditions: Tethered Cord

Interventions: Drug: ketamine and dexmeditomidine combination
Drug: Propofol

First Posted Date: 2022-10-21

Last Posted Date: 2024-02-07

Lead Sponsor: Cairo University

Target Recruit Count: 46

Registration Number: NCT05591001

Locations: 🇪🇬
Amany Hassan Saleh, Giza, Egypt

Comparison of the Effect of Remimazolam and Propofol on Perioperative Hypothermia Under Spinal Anesthesia

Not Applicable

Completed

Conditions: Lower Extremity Problem
Gynecologic Disease
Urinary Tract Disease

Interventions: Drug: Propofol
Drug: Remimazolam

First Posted Date: 2022-10-10

Last Posted Date: 2022-10-10

Lead Sponsor: Wonkwang University Hospital

Target Recruit Count: 82

Registration Number: NCT05574257

Locations: 🇰🇷
Wonkwag UH, Iksan, Jeollabukdo, Korea, Republic of

Long-term Sedation With Remimazolam Besylate in Critically Ill Patients

Phase 3

Recruiting

Conditions: Light Sedation
Mechanical Ventilation

Interventions: Drug: Remimazolam besylate
Drug: Propofol

First Posted Date: 2022-09-27

Last Posted Date: 2023-05-26

Lead Sponsor: Wuhan Union Hospital, China

Target Recruit Count: 728

Registration Number: NCT05555667

Locations: 🇨🇳
Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Endoscopic Hemostatic and Sedative Treatment of Esophageal and Gastric Variceal Bleeding

Phase 4

Conditions: Endoscopic Hemostasis
Sedation

Interventions: Drug: Remimazolam besylate
Drug: Propofol

First Posted Date: 2022-09-26

Last Posted Date: 2022-11-10

Lead Sponsor: Renmin Hospital of Wuhan University

Target Recruit Count: 60

Registration Number: NCT05554965

Locations: 🇨🇳
Renmin Hospital of Wuhan University, Wuhan, Hubei, China

Comparison of Analgesic and Sedative Effects of Esmketamine and Remifentanil Combined With Propofol Respectively in Septic Shock Patients With Invasive Mechanical Ventilation

Not Applicable

Not yet recruiting

Conditions: Patients With Septic Shock Admitted to the ICU on Invasive Mechanical Ventilation

Interventions: Drug: Esketamine
Drug: Remifentanil
Drug: propofol

First Posted Date: 2022-09-23

Last Posted Date: 2022-09-23

Lead Sponsor: The First Hospital of Jilin University

Target Recruit Count: 120

Registration Number: NCT05551910

Sedation Level on Machine Learning With Electroencephalogram in Painless Gastroenteroscopy Patients

Recruiting

Conditions: Gastritis

Interventions: Drug: Propofol
Device: EEG montior

First Posted Date: 2022-09-19

Last Posted Date: 2022-09-21

Lead Sponsor: General Hospital of Ningxia Medical University

Target Recruit Count: 50

Registration Number: NCT05545397

Locations: 🇨🇳
Ningxia Medical University Cardiovascular and Cerebrovascular Disease Hospital, Yinchuan, The Ningxia Hui Autonomous Region, China

Ultrasound Guided Psoas Compartment Block vs Suprainguinal Fascia Iliaca Compartment Block

Not Applicable

Conditions: Pain, Postoperative
Hip Dysplasia

Interventions: Drug: Fentanyl
Drug: Propofol
Drug: Rocuronium
Drug: Sevoflurane
Drug: Ropivacaine

First Posted Date: 2022-09-16

Last Posted Date: 2022-09-30

Lead Sponsor: Tanta University

Target Recruit Count: 85

Registration Number: NCT05543109

Locations: 🇪🇬
Mona Mohamed Mogahed, Tanta, Elgharbia, Egypt

Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Critically Ill Patients With Deep Sedation

Phase 2

Recruiting

Conditions: Critically Ill
Deep Sedation

Interventions: Drug: Remimazolam Besylate
Drug: Propofol

First Posted Date: 2022-09-14

Last Posted Date: 2022-09-26

Lead Sponsor: Wuhan Union Hospital, China

Target Recruit Count: 60

Registration Number: NCT05539521

Locations: 🇨🇳
Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China