Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Comparison the Hemodynamics Effects Between Dexmedetomidine and Propofol in Major Abdominal Surgical Patients

Conditions: Abdominal Tumor
Intestinal Obstruction
Cirrhosis
Intestinal Fistula
Aneurism

Interventions: Drug: dexmedetomidine
Drug: propofol

First Posted Date: 2012-08-20

Last Posted Date: 2012-08-22

Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Target Recruit Count: 80

Registration Number: NCT01669044

Locations: 🇨🇳
First affiliated hostipal,Sun Yat-sen University, Guangzhou, Guangdong, China

Propofol Effect-Site Target Controlled Infusion in the Obese: Characterization of the Time Profile of Bispectral Index Response

Phase 4

Completed

Conditions: Obesity

Interventions: Drug: Propofol

First Posted Date: 2012-08-15

Last Posted Date: 2012-08-15

Lead Sponsor: Universidad del Desarrollo

Target Recruit Count: 14

Registration Number: NCT01665079

Locations: 🇨🇱
Clinica Alemana, Santiago, Chile

Markers of Alzheimers Disease After Propofol or Isoflurane Anesthesia

Phase 1

Completed

Conditions: General Anesthesia

Interventions: Drug: Propofol
Drug: Isoflurane

First Posted Date: 2012-07-13

Last Posted Date: 2015-08-04

Lead Sponsor: Duke University

Target Recruit Count: 105

Registration Number: NCT01640275

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury

Phase 4

Completed

Conditions: Total Knee Arthroplasty
Tourniquet-Induced Ischemia-Reperfusion Injury

Interventions: Drug: Placebo
Drug: Propofol

First Posted Date: 2012-07-12

Last Posted Date: 2016-06-13

Lead Sponsor: Diskapi Teaching and Research Hospital

Target Recruit Count: 36

Registration Number: NCT01638624

Locations: 🇹🇷
Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology and Biochemistry Clinics, Ankara, Turkey

Correlation of Bispectral Index Score and Total Intravenous Anesthesia (TIVA)

Terminated

Conditions: Benign/Malignant Neoplasm
Long Bone Fracture

First Posted Date: 2012-06-13

Last Posted Date: 2017-03-14

Lead Sponsor: Rutgers, The State University of New Jersey

Target Recruit Count: 31

Registration Number: NCT01618539

Locations: 🇺🇸
University Hospital, Newark, New Jersey, United States

Laryngeal Injuries After Removal of the Tracheal Tube: A Comparison Between Sevoflurane and Propofol

Not Applicable

Completed

Conditions: Vocal Cord; Injury, Superficial

Interventions: Drug: Sevoflurane
Drug: propofol

First Posted Date: 2012-06-12

Last Posted Date: 2012-07-03

Lead Sponsor: University of Rostock

Target Recruit Count: 65

Registration Number: NCT01616966

Locations: 🇩🇪
University of Rostock, Rostock, Mecklenburg/Vorpommern, Germany

Low-dose Propofol for Pediatric Migraine

Phase 2

Completed

Conditions: Migraine Headache

Interventions: Drug: Propofol
Drug: Standard Treatment

First Posted Date: 2012-05-24

Last Posted Date: 2018-12-31

Lead Sponsor: Oregon Health and Science University

Target Recruit Count: 74

Registration Number: NCT01604785

Locations: 🇺🇸
Oregon Health & Science University, Portland, Oregon, United States

Validation of a Pharmacokinetic Pharmacodynamic Model to Administer Propofol in Obese Patients

Phase 4

Completed

Conditions: Obesity

Interventions: Drug: Propofol

First Posted Date: 2012-05-11

Last Posted Date: 2012-05-11

Lead Sponsor: Pontificia Universidad Catolica de Chile

Target Recruit Count: 20

Registration Number: NCT01596387

Locations: 🇨🇱
Hospital Clinico Pontificia Universidad Catolica, Santiago, Region Metropolitana, Chile

A High Resolution Pharmacokinetic/Pharmacodynamic Model of Propofol in Morbidly Obese Subjects

Phase 1

Completed

Conditions: Morbid Obesity

Interventions: Drug: propofol

First Posted Date: 2012-05-03

Last Posted Date: 2017-12-29

Lead Sponsor: Stanford University

Target Recruit Count: 30

Registration Number: NCT01591148

Locations: 🇺🇸
Stanford University School of Medicine, Stanford, California, United States

Safety Study of Two Regimen for Sedation for Transesophageal Echocardiography

Phase 2

Completed

Conditions: Hypotension

Interventions: Drug: Propofol
Drug: pethidin hydrochlorid, midazolam

First Posted Date: 2012-03-30

Last Posted Date: 2013-01-28

Lead Sponsor: Kantonsspital Münsterlingen

Target Recruit Count: 200

Registration Number: NCT01567657

Locations: 🇨🇭
Kantonsspital Münsterlingen, Münsterlingen, Kanton Thurgau, Switzerland

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