DeepMed Research

Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Dexmedetomidine Infusion Dose Versus Rapid Bolus Dose Before Tracheal Intubation.

Phase 2

Recruiting

Conditions: Dexmedetomidine
Intubation Complication

Interventions: Drug: Dexmedetomidine bolus
Drug: Dexmedetomidine infusion
Drug: Atropine Sulfate
Drug: Ephedrine
Drug: Propofol

First Posted Date: 2024-03-25

Last Posted Date: 2024-03-25

Lead Sponsor: Kasr El Aini Hospital

Target Recruit Count: 70

Registration Number: NCT06327399

Locations: 🇪🇬
Cairo University Hospitals, Giza, Egypt

Propofol Versus Dexmedetomidine Effect on Prevention Emergence Agitation

Phase 4

Recruiting

Conditions: Emergence Agitation

Interventions: Drug: Propofol
Drug: Dexmedetomidine

First Posted Date: 2024-03-15

Last Posted Date: 2024-11-06

Lead Sponsor: Ain Shams University

Target Recruit Count: 30

Registration Number: NCT06312618

Locations: 🇪🇬
Ain Shams University, Cairo, Egypt

Comparison Between Drugs for Control of Emetic Attacks During Caesarean Delivery

Not Applicable

Not yet recruiting

Conditions: Emetic Attacks During Caesarean Delivery With Spinal Anesthesia

Interventions: Drug: Propofol

First Posted Date: 2024-03-08

Last Posted Date: 2024-03-08

Lead Sponsor: Sohag University

Target Recruit Count: 90

Registration Number: NCT06300346

Differences in Speed of Recovery From Anesthesia for Intraoral Surgery

Not Applicable

Recruiting

Conditions: Intraoral Tumor

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2024-02-23

Last Posted Date: 2024-10-17

Lead Sponsor: Clinical Hospital Centre Zagreb

Target Recruit Count: 42

Registration Number: NCT06275087

Locations: 🇭🇷
University Hospital Centre Zagreb, Zagreb, Croatia

Ciprofol Titrated Induction in Reducing Post-induction Hypotension in Geriatric Patients

Not Applicable

Recruiting

Conditions: Post Induction Hypotension
Elderly

Interventions: Drug: propofol
Drug: ciprofol

First Posted Date: 2024-02-14

Last Posted Date: 2024-07-15

Lead Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University

Target Recruit Count: 160

Registration Number: NCT06258967

Locations: 🇨🇳
the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

Efficacy and Safety of Fospropofol for Same-day Bidirectional Endoscopy in Elderly Patients

Phase 4

Not yet recruiting

Conditions: Elderly Patients

Interventions: Drug: fospropofol sedation
Drug: Propofol

First Posted Date: 2024-02-09

Last Posted Date: 2024-02-09

Lead Sponsor: Shanghai 6th People's Hospital

Target Recruit Count: 256

Registration Number: NCT06251999

Ketamine Versus Propofol as ICU Sedation

Phase 4

Completed

Conditions: Propofol
Ketamine
Sedation
Mechanical Ventilation

Interventions: Drug: Propofol
Drug: Ketamine

First Posted Date: 2024-02-06

Last Posted Date: 2024-02-06

Lead Sponsor: Menoufia University

Target Recruit Count: 100

Registration Number: NCT06243822

Locations: 🇪🇬
Menoufia University, Shibīn Al Kawm, Menoufia, Egypt

A Study of Remimazolam Tosilate for Sedation in the ICU

Phase 3

Completed

Conditions: Sedation in the ICU

Interventions: Drug: Propofol Medium and Long Chain Fat Emulsion Injection
Drug: Remimazolam Tosilate

First Posted Date: 2024-01-24

Last Posted Date: 2024-11-15

Lead Sponsor: Jiangsu HengRui Medicine Co., Ltd.

Target Recruit Count: 214

Registration Number: NCT06222294

Locations: 🇨🇳
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

Efficacy of Low Dose Propofol Given at the End of Sevoflurane Anesthesia for Prevention of Emergence Agitation in Pediatric Patient Undergoing MRI Scan

Not Applicable

Not yet recruiting

Conditions: Emergence Agitation

Interventions: Drug: Normal saline
Drug: Propofol

First Posted Date: 2024-01-23

Last Posted Date: 2024-01-23

Lead Sponsor: Khon Kaen University

Target Recruit Count: 134

Registration Number: NCT06218680

Locations: 🇹🇭
Khon kaen University, Khon Kaen, Muang, Thailand

Recovery of TIVA vs Inhalation in Pediatric Anesthesia

Not yet recruiting

Conditions: Best Technique for Pediatric Anesthesia

Interventions: Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2024-01-22

Last Posted Date: 2024-01-30

Lead Sponsor: Assiut University

Target Recruit Count: 120

Registration Number: NCT06215833

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