Neostigmine
- Generic Name
- Neostigmine
- Brand Names
- Bloxiverz, Prevduo, Prostigmin
- Drug Type
- Small Molecule
- Chemical Formula
- C12H19N2O2
- CAS Number
- 59-99-4
- Unique Ingredient Identifier
- 3982TWQ96G
- Background
A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.
- Indication
Neostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.
- Associated Conditions
- Curarization therapy, Myasthenia Gravis, Neuromuscular Blockade, Postoperative Urinary Retention (POUR), Acute Colonic Pseudo-Obstruction, Post-operative intestinal atony
Using Diaphragm Ultrasonography, Sugammadex Recovers Diaphragmatic Function More Effectively Than Neostigmine.
Phase 1
Completed
- Conditions
- Perioperative Diaphragmatic Function
- Interventions
- First Posted Date
- 2025-05-21
- Last Posted Date
- 2025-05-21
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 60
- Registration Number
- NCT06982092
- Locations
- 🇪🇬
faculty of medicine, ain shams University, Cairo, Egypt
Recovery Times of Half Dose Sugammadex and Neostigmine for Rocuronium-induced Neuromuscular Blockade
Phase 1
Recruiting
- Conditions
- Neuromuscular Blocking AgentsReversal of Neuromuscular BlockadeRecovery Time
- Interventions
- First Posted Date
- 2025-01-27
- Last Posted Date
- 2025-01-28
- Lead Sponsor
- Universitas Padjadjaran
- Target Recruit Count
- 60
- Registration Number
- NCT06794450
- Locations
- 🇮🇩
Hasan Sadikin General Hospital, Bandung, Jawa Barat, Indonesia
Low-dose Neostigmine at TOF Ratio of 0.7 Improves Neuromuscular Recovery
Completed
- Conditions
- Recovery Time
- First Posted Date
- 2024-12-20
- Last Posted Date
- 2024-12-20
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 59
- Registration Number
- NCT06745492
- Locations
- 🇰🇷
Seoul National University Bundang Hospital, Seongnam, Korea, Republic of
Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries
Phase 1
Not yet recruiting
- Conditions
- Post-Dural Puncture Headache
- Interventions
- First Posted Date
- 2024-12-11
- Last Posted Date
- 2024-12-11
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 330
- Registration Number
- NCT06729047
- Locations
- 🇪🇬
Faculty of medicine, Assiut University, Assiut, Egypt,, Assiut, Egypt
Effect of Two Different Doses of Neostigmine on the Gastric Residual Volume and Aspiration in Critically Ill Patients
- First Posted Date
- 2024-11-13
- Last Posted Date
- 2024-11-13
- Lead Sponsor
- Zulekha Hospitals
- Target Recruit Count
- 3
- Registration Number
- NCT06687187
- Locations
- 🇪🇬
Al-Azhar faculty of medicine, Cairo, Egypt
Sugammadex on Laparoscopic Bariatric Surgery
Not Applicable
Not yet recruiting
- Conditions
- Laparoscopic Bariatric SurgerySugammadex
- Interventions
- First Posted Date
- 2024-11-07
- Last Posted Date
- 2024-11-07
- Lead Sponsor
- Shanxi Bethune Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT06678451
Sugammadex and Time to Extubation in Ophthalmic Surgery
Completed
- Conditions
- General Anesthesia Using Endotracheal IntubationOphthalmologic Surgical ProcedureSugammadexNeostigmineExtubation Readiness
- Interventions
- First Posted Date
- 2024-10-08
- Last Posted Date
- 2024-10-08
- Lead Sponsor
- China Medical University Hospital
- Target Recruit Count
- 262
- Registration Number
- NCT06632067
- Locations
- 🇨🇳
China Medical University Hospital, Taichung, Taiwan
MgSO4 as Adjuvants to Bupivacaine vs Neostigmine in TAP Block in Cesarean Section
Phase 2
Not yet recruiting
- Conditions
- Cesarean Section
- Interventions
- Procedure: transversus abdominis plane (TAP) block in cesarean section
- First Posted Date
- 2024-07-22
- Last Posted Date
- 2024-07-22
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 68
- Registration Number
- NCT06513013
Comparative Study Between Dexmedetomidine & Neostigmine as an Adjuvant to Local Anesthetic Mixture in Peribulbar Block in Vitreoretinal Surgeries
Early Phase 1
Completed
- Conditions
- Vitreoretinal SurgeriesLocal Anesthesia
- Interventions
- First Posted Date
- 2024-07-15
- Last Posted Date
- 2024-07-15
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 81
- Registration Number
- NCT06501352
- Locations
- 🇪🇬
Ain Shams University Hospitals, Cairo, Egypt
Clinical Efficacy of Prophylactic Intravenous Neostigmine and Atropine in Preventing Post-Dural Puncture Headache Among Parturient Undergoing Spinal Anesthesia for Cesarean Section: A Double-blind Randomized Placebo-controlled Trial
Phase 4
Not yet recruiting
- Conditions
- Acute Pain
- Interventions
- Drug: intravenous 50 mL of saline injection of 0.9% after umbilical cord clamping.
- First Posted Date
- 2024-07-10
- Last Posted Date
- 2024-07-16
- Lead Sponsor
- Minia University
- Target Recruit Count
- 180
- Registration Number
- NCT06493838
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