Neostigmine
- Generic Name
- Neostigmine
- Brand Names
- Bloxiverz, Prevduo, Prostigmin
- Drug Type
- Small Molecule
- Chemical Formula
- C12H19N2O2
- CAS Number
- 59-99-4
- Unique Ingredient Identifier
- 3982TWQ96G
- Background
A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.
- Indication
Neostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.
- Associated Conditions
- Curarization therapy, Myasthenia Gravis, Neuromuscular Blockade, Postoperative Urinary Retention (POUR), Acute Colonic Pseudo-Obstruction, Post-operative intestinal atony
Neostigmine and Glycopyrrolate for the Treatment of Headache After Dural Puncture
- Conditions
- Post-Dural Puncture Headache
- Interventions
- First Posted Date
- 2021-11-11
- Last Posted Date
- 2025-04-06
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 18
- Registration Number
- NCT05116930
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Residual Paralysis and Reversal With Routine Neostigmine Versus Half-dose Sugammadex and Routine Neostigmine
- Conditions
- Complication of AnesthesiaPostoperative Residual CurarizationSugammadexNeuromuscular BlockadeNeostigmineRocuronium
- Interventions
- First Posted Date
- 2021-10-04
- Last Posted Date
- 2021-10-04
- Lead Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
- Target Recruit Count
- 113
- Registration Number
- NCT05066035
Different Doses of Neostigmine for Reversal of Moderate Neuromuscular Blockade in Children
- Conditions
- Neuromuscular Block ProlongedNeuromuscular BlockadeNeuromuscular Block, Residual
- Interventions
- First Posted Date
- 2021-09-22
- Last Posted Date
- 2021-09-22
- Lead Sponsor
- Pontificia Universidade Catolica de Sao Paulo
- Target Recruit Count
- 60
- Registration Number
- NCT05053594
Comparative Efficacy and Safety of Sugammadex and Neostigmine
- First Posted Date
- 2021-08-10
- Last Posted Date
- 2022-03-10
- Lead Sponsor
- Chang Gung Memorial Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT04997759
- Locations
- 🇨🇳
Yu-Hsun-Tsai, Taoyuan, Taiwan
Neostigmine Route for Acute Colonic Pseudo Obstruction
- First Posted Date
- 2021-07-07
- Last Posted Date
- 2023-08-25
- Lead Sponsor
- University of Southern California
- Target Recruit Count
- 90
- Registration Number
- NCT04951726
- Locations
- 🇺🇸
Los Angeles University of Southern California Medical Center, Los Angeles, California, United States
Comparison Of Different Doses Of Intrathecal Neostigmine In Prevention Of Post-Dural Puncture Headache
- Conditions
- Headache
- First Posted Date
- 2021-05-28
- Last Posted Date
- 2021-05-28
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 274
- Registration Number
- NCT04905953
- Locations
- 🇪🇬
Faculty of Medicine- Cairo University, Cairo, Egypt
Feasibility of Neostigmine for Intraoperative Neuromonitoring in Thyroid Surgery
- Conditions
- Thyroid DiseasesNerve MonitoringSurgical Injury
- Interventions
- Drug: Normal saline
- First Posted Date
- 2021-05-05
- Last Posted Date
- 2022-03-04
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 44
- Registration Number
- NCT04873531
- Locations
- 🇰🇷
Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea, Republic of
The Effects of Iontophoresed Vasoactive Drugs on Cutaneus Blood Flow
- Conditions
- Cardiovascular DiseasesVascular Diseases
- Interventions
- First Posted Date
- 2021-03-02
- Last Posted Date
- 2021-03-02
- Lead Sponsor
- University Hospital, Linkoeping
- Target Recruit Count
- 90
- Registration Number
- NCT04777383
- Locations
- 🇸🇪
University Hospital Linköping, Linköping, Östergötland, Sweden
Reversal of Neuromuscular Blockade and Perioperative Arrhythmias
- Conditions
- Neuromuscular Blockade
- Interventions
- First Posted Date
- 2021-01-22
- Last Posted Date
- 2021-01-22
- Lead Sponsor
- Başakşehir Çam & Sakura City Hospital
- Target Recruit Count
- 80
- Registration Number
- NCT04720573
- Locations
- 🇹🇷
Istanbul Medipol University, Istanbul, Turkey
Use of a Prokinetic Agent as an Adjunct to Thrice Weekly Bowel Care After SCI
- Conditions
- Spinal Cord InjuriesNeurogenic BowelConstipation
- Interventions
- Device: Iontophoresis
- First Posted Date
- 2020-12-17
- Last Posted Date
- 2021-12-30
- Lead Sponsor
- James J. Peters Veterans Affairs Medical Center
- Target Recruit Count
- 6
- Registration Number
- NCT04671030
- Locations
- 🇺🇸
James J Peters VA Medical Center, Bronx, New York, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.