DeepMed Research

Neostigmine

Generic Name: Neostigmine

Brand Names: Bloxiverz, Prevduo, Prostigmin

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₉N_₂O_₂

CAS Number: 59-99-4

Unique Ingredient Identifier: 3982TWQ96G

Background: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.

Indication: Neostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.

Associated Conditions: Curarization therapy, Myasthenia Gravis, Neuromuscular Blockade, Postoperative Urinary Retention (POUR), Acute Colonic Pseudo-Obstruction, Post-operative intestinal atony

Clinical Trials

Efficacy and Safety of Sugammadex in Thoracoscopy Thymectomy for Chinese Adults With Myasthenia Gravis

Not Applicable

Completed

Conditions: Reversal of Neuromuscular Blockade

Interventions: Drug: Sugammadex
Drug: Neostigmine

First Posted Date: 2024-05-31

Last Posted Date: 2025-04-02

Lead Sponsor: Beijing Tongren Hospital

Target Recruit Count: 62

Registration Number: NCT06436768

Locations: 🇨🇳
Beijing tongren Hospital, Capital Medical University, Beijing, Beijing, China
🇨🇳
The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China

The Clinical Effect of Sugammadex Sodium (Domestic) for Antagonizing Neuromuscular Blockade After Thoracic Surgery

Not Applicable

Recruiting

Conditions: Neuromuscular Blockade

Interventions: Drug: SUGAMMADEX SODIUM 100 Mg in 1 mL
Drug: Neostigmine

First Posted Date: 2024-03-28

Last Posted Date: 2025-02-17

Lead Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine

Target Recruit Count: 80

Registration Number: NCT06334562

Locations: 🇨🇳
The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, Zhejiang, China

Ability to Maintain Saturation Levels Without Oxygen Supplementation as a Extubation Criteria Without TOF Monitoring Equipment

Not Applicable

Conditions: Anesthesia Intubation Complication

Interventions: Device: Train of four monitoring device intraoperative
Drug: Neostigmine
Procedure: Air chalenge prior to extubation
Device: Train of Four monitoring device in recovery room

First Posted Date: 2024-02-23

Last Posted Date: 2025-04-01

Lead Sponsor: University of Surabaya

Target Recruit Count: 240

Registration Number: NCT06275542

Locations: 🇮🇩
Sardjito General Hospital, Yogyakarta, Indonesia

Effects of Sugammadex and Conventional Reversal on Lung Function in Laparoscopic Abdominal Surgery

Not Applicable

Recruiting

Conditions: Atelectasis, Postoperative
Pulmonary Function; Newborn, Abnormal

Interventions: Drug: Neostigmine and atropine
Drug: Sugammadex

First Posted Date: 2024-01-18

Last Posted Date: 2024-01-18

Lead Sponsor: Rhendra Hardy Mohamad Zaini

Target Recruit Count: 80

Registration Number: NCT06210165

Locations: 🇲🇾
University of Science Malaysia Hospital, Kubang Kerian, Kelantan, Malaysia

Sugammadex Vs Neostigmine in Reversing Neuromuscular Blocks in Outpatient ERCP. A Randomized, Double-Blinded Trial

Not Applicable

Recruiting

Conditions: Neuromuscular Blocks

Interventions: Drug: 2 mg/kg sugammadex
Drug: 0.07 mg/kg neostigmine

First Posted Date: 2023-11-18

Last Posted Date: 2024-07-01

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 80

Registration Number: NCT06136585

Locations: 🇺🇸
Cleveland Clinic Foundation, Cleveland, Ohio, United States

Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel Resection

Phase 4

Recruiting

Conditions: Intestinal Disease

Interventions: Drug: Neostigmine Injectable Solution
Drug: Sugammadex injection

First Posted Date: 2023-11-01

Last Posted Date: 2024-08-12

Lead Sponsor: University of California, Irvine

Target Recruit Count: 128

Registration Number: NCT06112353

Locations: 🇺🇸
UC Irvine Medical Center, Orange, California, United States

Neostigmine Versus Sugammadex on Renal Functions

Phase 4

Active, not recruiting

Conditions: Sugammadex
Neostigmine

Interventions: Drug: Sugammadex
Drug: Neostigmine

First Posted Date: 2023-10-13

Last Posted Date: 2023-10-13

Lead Sponsor: Menoufia University

Target Recruit Count: 64

Registration Number: NCT06081738

Locations: 🇪🇬
Menoufia University Hospitals, Shibīn Al Kawm, Menoufia, Egypt

Regional Anaesthesia

Not Applicable

Completed

Conditions: Anesthesia, Obstetric

Interventions: Drug: DEXMEDETOMIDINE
Drug: Neostigmine
Drug: Bupivacaine

First Posted Date: 2023-09-26

Last Posted Date: 2023-09-26

Lead Sponsor: Reham Ali Abdelhaleem Abdelrahman

Target Recruit Count: 54

Registration Number: NCT06055101

Locations: 🇪🇬
Reham Ali Abdelrahman, Cairo, Egypt

Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients

Not Applicable

Recruiting

Conditions: Critical Illness
Neuromuscular Blockade
Neurologic Findings

Interventions: Drug: Sugammadex
Drug: Neostigmine

First Posted Date: 2023-08-15

Last Posted Date: 2024-06-24

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 30

Registration Number: NCT05993390

Locations: 🇰🇷
Seoul National University Hospital, Seoul, Jongno-gu, Korea, Republic of

The Impact of Sugammadex on Ileus After Abdominal Wall Reconstruction

Phase 4

Recruiting

Conditions: Ileus
Hernia, Ventral

Interventions: Drug: Neostigmine / Glycopyrrolate
Drug: Sugammadex

First Posted Date: 2023-08-14

Last Posted Date: 2025-01-22

Lead Sponsor: Clayton Petro

Target Recruit Count: 184

Registration Number: NCT05985343

Locations: 🇺🇸
Cleveland Clinic Center for Abdominal Core Health, Cleveland, Ohio, United States

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