Neostigmine
- Generic Name
- Neostigmine
- Brand Names
- Bloxiverz, Prevduo, Prostigmin
- Drug Type
- Small Molecule
- Chemical Formula
- C12H19N2O2
- CAS Number
- 59-99-4
- Unique Ingredient Identifier
- 3982TWQ96G
- Background
A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.
- Indication
Neostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.
- Associated Conditions
- Curarization therapy, Myasthenia Gravis, Neuromuscular Blockade, Postoperative Urinary Retention (POUR), Acute Colonic Pseudo-Obstruction, Post-operative intestinal atony
- Associated Therapies
- -
A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2010-06-02
- Last Posted Date
- 2010-06-02
- Lead Sponsor
- University of Nottingham
- Target Recruit Count
- 10
- Registration Number
- NCT01134848
- Locations
- 🇬🇧
University of Nottingham, Nottingham, Nottinghamshire, United Kingdom
Comparison of Sugammadex With Neostigmine as Reversal Agents for Rocuronium at Reappearance of T2 (Study P06101)
- First Posted Date
- 2010-01-15
- Last Posted Date
- 2017-07-02
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 128
- Registration Number
- NCT01050543
Sugammadex and Neostigmine at Residual Neuromuscular Blockade
- Conditions
- Interventions
- First Posted Date
- 2009-11-03
- Last Posted Date
- 2012-12-13
- Lead Sponsor
- Technical University of Munich
- Target Recruit Count
- 99
- Registration Number
- NCT01006720
- Locations
- 🇩🇪
Klinik für Anaesthesiologie, Klinikum rechts der Isar der Technischen Universität München, Munic, Bavaria, Germany
Comparision of Different Dose of Neostigmine at Advanced Decurarization
- First Posted Date
- 2009-02-19
- Last Posted Date
- 2019-05-29
- Lead Sponsor
- Centre Hospitalier Departemental Vendee
- Target Recruit Count
- 62
- Registration Number
- NCT00847938
- Locations
- 🇫🇷
CHD Vendée, La Roche Sur Yon, France
Comparison of 2.0 mg/kg Sugammadex and Neostigmine at Reappearance of T2 in Chinese and European Subjects (Study 19.4.324)(P05768AM1)(COMPLETED)
- Conditions
- Interventions
- First Posted Date
- 2009-01-21
- Last Posted Date
- 2015-11-01
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 308
- Registration Number
- NCT00825812
Epidural Neostigmine for Labor Pain
- First Posted Date
- 2008-10-24
- Last Posted Date
- 2018-09-11
- Lead Sponsor
- Wake Forest University
- Target Recruit Count
- 200
- Registration Number
- NCT00779467
- Locations
- 🇺🇸
Forsyth Medical Center, Winston-Salem, North Carolina, United States
Efficacy and Safety of Standard Oral Colonoscopic Preparations With or Without Neostigmine Compared to Pulse-Irrigation Colonic Lavage
- First Posted Date
- 2008-09-03
- Last Posted Date
- 2014-07-16
- Lead Sponsor
- US Department of Veterans Affairs
- Target Recruit Count
- 360
- Registration Number
- NCT00745095
- Locations
- 🇺🇸
VA Medical Center, Bronx, Bronx, New York, United States
Comparison of Sugammadex With Neostigmine During Laparoscopic Cholecystectomy or Appendectomy (P05699)
- Conditions
- Interventions
- First Posted Date
- 2008-07-30
- Last Posted Date
- 2017-05-16
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 140
- Registration Number
- NCT00724932
A New Approach of Neostigmine in Unavoidable Post Operative Ileus
- First Posted Date
- 2008-05-13
- Last Posted Date
- 2008-05-13
- Lead Sponsor
- Baqiyatallah Medical Sciences University
- Target Recruit Count
- 3
- Registration Number
- NCT00676377
- Locations
- 🇮🇷
Baqyiattalah University of Medical Science, Tehran, Iran, Islamic Republic of
Comparison of Sugammadex Administered at 1-2 Post Tetanic Counts (PTCs) or Better With Neostigmine Administered as Per Standard of Care to Reverse Rocuronium-Induced Neuromuscular Blockade in Adults Undergoing Elective Open Abdominal Procedure (19.4.334) (P05774)
- First Posted Date
- 2008-05-12
- Last Posted Date
- 2015-03-13
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 100
- Registration Number
- NCT00675792
Drug Development Updates
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