Neostigmine

Generic Name: Neostigmine

Brand Names: Bloxiverz, Prevduo, Prostigmin

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₉N_₂O_₂

CAS Number: 59-99-4

Unique Ingredient Identifier: 3982TWQ96G

Background: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.

Indication: Neostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.

Associated Conditions: Curarization therapy, Myasthenia Gravis, Neuromuscular Blockade, Postoperative Urinary Retention (POUR), Acute Colonic Pseudo-Obstruction, Post-operative intestinal atony

Associated Therapies: -

Clinical Trials

Electromyographic Activity of the Respiratory Muscles During Neostigmine or Sugammadex Enhanced Recovery After Neuromuscular Blockade

Phase 4

Completed

Conditions: Respiratory Muscles
Electromyography

Interventions: Drug: Neostigmine-sugammadex
Drug: Sugammadex
Drug: Neostigmine

First Posted Date: 2015-03-31

Last Posted Date: 2015-11-20

Lead Sponsor: Onze Lieve Vrouw Hospital

Target Recruit Count: 18

Registration Number: NCT02403063

Locations: 🇧🇪
OLV Hospital, Aalst, Belgium

Effect of Sugammadex for Muscle Motor Response and Awareness in Intraoperative Wakeup

Phase 4

Completed

Conditions: Spinal Curvatures

Interventions: Drug: Sugammadex
Drug: Neostigmine

First Posted Date: 2015-03-18

Last Posted Date: 2018-03-05

Lead Sponsor: Cukurova University

Target Recruit Count: 60

Registration Number: NCT02390817

Locations: 🇹🇷
Ebru Biricik, Adana, Sarıçam, Turkey
🇹🇷
Çukurova University, Adana, Çukurova, Turkey

"Low Dose Sugammadex Combined With Neostigmine and Glycopyrrolate Versus Full Dose Sugammadex for Reversal of Rocuronium-induced Neuromuscular Blockade: a Cost Saving Strategy"

Phase 4

Completed

Conditions: Anesthesia Recovery

Interventions: Drug: Sugammadex
Drug: Neostigmine
Drug: glycopyrrolate

First Posted Date: 2015-03-02

Last Posted Date: 2018-06-27

Lead Sponsor: American University of Beirut Medical Center

Target Recruit Count: 56

Registration Number: NCT02375217

Locations: 🇱🇧
AUBMC, Beirut, Lebanon

Effects of Neuromuscular Block Reversal With Sugammadex vs Neostigmine on Postoperative Respiratory Outcomes After Major Abdominal Surgery

Phase 4

Completed

Conditions: Major Abdominal Surgery

Interventions: Drug: Sugammadex
Drug: Neostigmine
Drug: Atropine

First Posted Date: 2015-02-11

Last Posted Date: 2017-02-23

Lead Sponsor: Enrique Alday Muñoz

Target Recruit Count: 130

Registration Number: NCT02361060

Locations: 🇪🇸
Hospital Universitario de La Princesa, Madrid, Spain
🇪🇸
Anesthesiology Service. Hospital Universitario La Princesa, Madrid, Spain

Effectiveness of Sugammadex in LMS Surgery

Phase 4

Conditions: Muscle Relaxation

Interventions: Drug: Sugammadex
Drug: Neostigmine

First Posted Date: 2015-01-01

Last Posted Date: 2015-09-28

Lead Sponsor: Korea University Anam Hospital

Target Recruit Count: 80

Registration Number: NCT02329964

Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy

Phase 4

Completed

Conditions: Gall Stone Disease

Interventions: Drug: Lidocaine
Drug: Esmolol
Drug: Paracetamol
Drug: Propofol
Drug: Fentanyl
Drug: Vecuronium
Drug: Atropine
Drug: Ephedrine
Drug: Morphine
Drug: Ketorolac
Drug: Ondansetron
Drug: Bupivacaine
Drug: Tramadol
Drug: Neostigmine
Drug: Glycopyrrolate

First Posted Date: 2014-12-31

Last Posted Date: 2018-11-30

Lead Sponsor: B.P. Koirala Institute of Health Sciences

Target Recruit Count: 90

Registration Number: NCT02327923

Locations: 🇳🇵
BP Koirala Institute of Health Sciences, Dharan, Sunsari District, Nepal

Comparison of the Effects of Neostigmine With Sugammadex on Postoperative Nausea and Vomiting.

Phase 4

Completed

Conditions: Incidence of Postoperative Nausea and Vomiting

Interventions: Drug: Neostigmine
Drug: sugammadex

First Posted Date: 2014-11-10

Last Posted Date: 2015-01-13

Lead Sponsor: T.C. ORDU ÜNİVERSİTESİ

Target Recruit Count: 98

Registration Number: NCT02286752

Locations: 🇹🇷
Anesthesiology and Reanimation Dept. Ordu University Training and Research Hospital, Altınordu, Ordu, Turkey

Functional Respiratory Imaging After Neostigmine or Sugammadex

Phase 4

Completed

Conditions: Respiratory-Gated Imaging Techniques

Interventions: Drug: Sugammadex
Drug: Neostigmine
Drug: Water for injection

First Posted Date: 2014-11-06

Last Posted Date: 2015-04-21

Lead Sponsor: Onze Lieve Vrouw Hospital

Target Recruit Count: 13

Registration Number: NCT02284412

Locations: 🇧🇪
OLV Hospital, Aalst, Belgium

A Randomized Double Blind Controlled Trial Comparing Sugammadex and Neostigmine After Thoracic Anesthesia

Phase 4

Terminated

Conditions: Neuromuscular Blockade

Interventions: Drug: Sugammadex
Drug: Neostigmine

First Posted Date: 2014-10-03

Last Posted Date: 2021-06-16

Lead Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Target Recruit Count: 70

Registration Number: NCT02256280

Locations: 🇮🇹
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Mi, Italy

Effect of Neuromuscular Reversal With Sugammadex on Postoperative Recovery Profile

Phase 4

Completed

Conditions: Postoperative Respiratory Condition

Interventions: Drug: Sugammadex
Drug: Neostigmine

First Posted Date: 2014-09-18

Last Posted Date: 2017-02-06

Lead Sponsor: Leiden University Medical Center

Target Recruit Count: 100

Registration Number: NCT02243943

Locations: 🇳🇱
Leiden Medical University, Leiden, Zuid Holland, Netherlands

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