Modafinil
- Generic Name
- Modafinil
- Brand Names
- Provigil
- Drug Type
- Small Molecule
- Chemical Formula
- C15H15NO2S
- CAS Number
- 68693-11-8
- Unique Ingredient Identifier
- R3UK8X3U3D
- Background
Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactiva...
- Indication
To improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy.
- Associated Conditions
- Attention Deficit Hyperactivity Disorder (ADHD), Fatigue, Major Depressive Disorder (MDD), Narcolepsy, Obstructive Sleep Apnea (OSA), Shift-work related sleep disturbance
- Associated Therapies
- -
Study to Evaluate the Efficacy of Modafinil Treatment in Patients With Attention Deficit Hyperactivity Disorder (ADHD) Who Are Responders to Modafinil Treatment
- Conditions
- First Posted Date
- 2006-06-23
- Last Posted Date
- 2014-05-09
- Lead Sponsor
- Cephalon
- Target Recruit Count
- 120
- Registration Number
- NCT00343811
- Locations
- 🇺🇸
UCI Child Development Center, Irvine, California, United States
🇺🇸Miami Research Associates, Miami, Florida, United States
🇺🇸Alpine Clinical Research, Boulder, Colorado, United States
Dose-Finding Study to Evaluate the Efficacy and Safety of Modafinil as Treatment for Adults With ADHD
- Conditions
- First Posted Date
- 2006-04-18
- Last Posted Date
- 2012-08-24
- Lead Sponsor
- Cephalon
- Target Recruit Count
- 370
- Registration Number
- NCT00315276
- Locations
- 🇺🇸
New York University, New York, New York, United States
🇺🇸UCSD Medical Center, San Diego, California, United States
🇺🇸Clinical Neuroscience Solution, Inc., Orlando, Florida, United States
Modafinil as an Adjunctive on Cognitive Functioning in Patients With Schizophrenia
- Conditions
- First Posted Date
- 2006-04-14
- Last Posted Date
- 2009-02-12
- Lead Sponsor
- Laval University
- Target Recruit Count
- 30
- Registration Number
- NCT00314639
- Locations
- 🇨🇦
Centre Hospitalier Robert-Giffard, Quebec, Canada
Memory and Attention Problems in Lupus: New Treatment Trial With Modafinil
- Conditions
- First Posted Date
- 2006-02-28
- Last Posted Date
- 2009-01-28
- Lead Sponsor
- Hospital for Special Surgery, New York
- Target Recruit Count
- 20
- Registration Number
- NCT00297284
- Locations
- 🇺🇸
Hospital for Special Surgery, New York, New York, United States
Modafinil in Opioid Induced Sedation
- First Posted Date
- 2005-12-20
- Last Posted Date
- 2018-05-07
- Target Recruit Count
- 90
- Registration Number
- NCT00267332
- Locations
- 🇺🇸
The Johns Hopkins Hospital, Baltimore, Maryland, United States
Assessment of Interactions Between Intravenous Methamphetamine and Modafinil - 1
- Conditions
- First Posted Date
- 2005-12-14
- Last Posted Date
- 2017-01-11
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Target Recruit Count
- 16
- Registration Number
- NCT00265278
- Locations
- 🇺🇸
U of CA, San Francisco, San Francisco, California, United States
Treatment of Orthostatic Intolerance
- Conditions
- Interventions
- Drug: AtomoxetineDrug: AcetazolamideDietary Supplement: MelatoninOther: NO DrugDrug: Isosorbide DinitrateRadiation: PlaceboDevice: Breathing DeviceOther: Drinking WaterProcedure: IV SalineDevice: Abdominal binderDrug: IndomethacinDrug: MidodrineDrug: MecamylamineDrug: ClonidineDrug: EntacaponeDrug: memantineDrug: ModafinilDrug: OctreotideDrug: SertralineDrug: Atomoxetine & PropranololDrug: Entacapone & PropranololDrug: PropranololDrug: Modafinil & Propranolol
- First Posted Date
- 2005-12-06
- Last Posted Date
- 2024-10-02
- Lead Sponsor
- Satish R. Raj
- Target Recruit Count
- 150
- Registration Number
- NCT00262470
- Locations
- 🇺🇸
Vanderbilt University Autonomic Dysfunction Center, Nashville, Tennessee, United States
Safety of Combining Modafinil and Nicotine Replacement Therapy in Treating Nicotine Dependent Adolescents
- Conditions
- Interventions
- First Posted Date
- 2005-11-24
- Last Posted Date
- 2017-05-11
- Lead Sponsor
- Catherine Martin, MD
- Target Recruit Count
- 24
- Registration Number
- NCT00258479
- Locations
- 🇺🇸
University of Kentucky, Lexington, Kentucky, United States
Post-Traumatic Brain Injury (Post-TBI) Fatigue and Its Treatment
- First Posted Date
- 2005-10-05
- Last Posted Date
- 2016-04-15
- Lead Sponsor
- Icahn School of Medicine at Mount Sinai
- Target Recruit Count
- 21
- Registration Number
- NCT00233090
- Locations
- 🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States
Study to Assess Satisfaction With Modafinil Treatment in Children and Adolescents With ADHD
- Conditions
- First Posted Date
- 2005-09-29
- Last Posted Date
- 2014-05-09
- Lead Sponsor
- Cephalon
- Registration Number
- NCT00228540
- Locations
- 🇺🇸
Laszlo J. Mate, MD, PA, West Palm Beach, Florida, United States
🇺🇸Loyola University Medical Center Department of Psychiatry, Maywood, Illinois, United States
🇺🇸Hurley Medical Center, Flint, Michigan, United States
Drug Development Updates
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