Modafinil
- Generic Name
- Modafinil
- Brand Names
- Provigil
- Drug Type
- Small Molecule
- Chemical Formula
- C15H15NO2S
- CAS Number
- 68693-11-8
- Unique Ingredient Identifier
- R3UK8X3U3D
- Background
Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactiva...
- Indication
To improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy.
- Associated Conditions
- Attention Deficit Hyperactivity Disorder (ADHD), Fatigue, Major Depressive Disorder (MDD), Narcolepsy, Obstructive Sleep Apnea (OSA), Shift-work related sleep disturbance
- Associated Therapies
- -
Modafinil Combined With Cognitive Behavior Therapy to Treat Cocaine Addiction - 1
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2019-04-10
- Lead Sponsor
- Medical University of South Carolina
- Target Recruit Count
- 123
- Registration Number
- NCT00218387
- Locations
- ๐บ๐ธ
Medical University of South Carolina, Charleston, South Carolina, United States
Evaluate the Safety and Efficacy of Modafinil in Children and Adolescents With ADHD
- Conditions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2012-07-26
- Lead Sponsor
- Cephalon
- Registration Number
- NCT00214981
- Locations
- ๐บ๐ธ
UCI Child Development Center, Irvine, California, United States
๐บ๐ธMarshfield Clinical Research, Marshfield, Wisconsin, United States
๐บ๐ธKentucky Pediatric/Adult Resea, Bardstown, Kentucky, United States
Assess the Safety and Effectiveness of PROVIGIL Treatment in Children and Adolescents With Excessive Sleepiness
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2012-05-31
- Lead Sponsor
- Cephalon
- Target Recruit Count
- 92
- Registration Number
- NCT00214968
Modafinil for Atypical Depression
- Conditions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2013-06-19
- Lead Sponsor
- Duke University
- Target Recruit Count
- 65
- Registration Number
- NCT00215176
Treatment of Orthostatic Hypotension in Autonomic Failure
- Conditions
- Interventions
- Drug: AtomoxetineDrug: placeboDrug: AcarboseDevice: inflatable abdominal binder (sham)Drug: Pyridostigmine BromideDrug: YohimbineDrug: Midodrine HClDrug: ModafinilDrug: OctreotideOther: water intakeDrug: Diphenhydramine HydrochlorideDrug: Ranitidine HCLDrug: TranylcypromineDrug: Ergotamine/ CaffeineDrug: CelecoxibDrug: PseudoephedrineDrug: MethylphenidateDrug: IndomethacinDrug: IbuprofenDrug: Oxymetazoline 0.05% nasal solutionDietary Supplement: BovrilDrug: AcetazolamideDrug: Rivastigmine tartrateDrug: Carbidopa/levodopaDevice: Inflatable abdominal binder
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2017-01-18
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 389
- Registration Number
- NCT00223691
- Locations
- ๐บ๐ธ
Vanderbilt University, Nashville, Tennessee, United States
Medications for Stopping Cocaine Dependence and Preventing Relapse
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2017-06-09
- Target Recruit Count
- 101
- Registration Number
- NCT00218023
- Locations
- ๐บ๐ธ
The University of Texas Health Science Center at Houston, Houston, Texas, United States
Fatigue Treatment Using Provigil
- Conditions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2006-02-17
- Lead Sponsor
- Sheba Medical Center
- Target Recruit Count
- 50
- Registration Number
- NCT00220506
- Locations
- ๐ฎ๐ฑ
Multiple Sclerosis Center, Tel Hashomer, Israel
Provigil in Conjunction With SSRIs for the Treatment of Mild or Moderate Depression With Attendant Symptoms of Sleepiness and Fatigue.
- Conditions
- First Posted Date
- 2005-09-21
- Last Posted Date
- 2013-11-11
- Lead Sponsor
- Emory University
- Target Recruit Count
- 100
- Registration Number
- NCT00208715
- Locations
- ๐บ๐ธ
Emory University, Atlanta, Georgia, United States
๐บ๐ธStanford University, Stanford, California, United States
๐บ๐ธMount Sinai School of Medicine, New York, New York, United States
Modafinil to Reduce Persistent Fatigue in Patients Following Treatment for Cancer
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2015-12-23
- Lead Sponsor
- University of Rochester
- Target Recruit Count
- 96
- Registration Number
- NCT00178373
- Locations
- ๐บ๐ธ
University of Rochester, James P. Wilmot Cancer Center, Rochester, New York, United States
Provigil (Modafinil) Study by Taiwan Biotech Co.
- Conditions
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2005-09-15
- Lead Sponsor
- National Taiwan University Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT00174174
Drug Development Updates
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