Chlorhexidine

Generic Name
Chlorhexidine
Brand Names
Betasept, Hibiclens, Instillagel, Nupro Chlorhexidine, Oris, Oro-Clense, Paroex, Perichlor, Peridex, Periochip, Periogard, Prevora, X-pur
Drug Type
Small Molecule
Chemical Formula
C22H30Cl2N10
CAS Number
55-56-1
Unique Ingredient Identifier
R4KO0DY52L
Background

Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings a...

Indication

Chlorhexidine is available over-the-counter in various formulations (e.g. solution, sponge, cloth, swab) as a topical antiseptic to sanitize prior to surgeries and/or medical procedures. Dental formulations, available by prescription only, include an oral rinse indicated for the treatment of gingivitis and a slow-release "chip" which is inserted into periodo...

Associated Conditions
Aphthous ulcer, Catarrh of the throat, Chemotherapy Induced Oral Mucositis, Chronic Wounds, Decubitus Ulcer, Dental Cavity, Dysphagia, Eczema infected, Foeter Ex Ore, Gingival Bleeding, Gingival Diseases, Gingivitis, Glossitis, Hoarseness, Infection, Infectious Periodontal Diseases, Injury Throat, Mild to Moderate Inflammatory Reaction of the Oral Cavity, Mild to Moderate Inflammatory Reaction of the Pharynx, Mouth injury, Mucositis, Neurodermatitis, Ocular Inflammation, Ocular Irritation, Oral Aphthous Ulcer, Pain, Periodontitis, Pharyngitis, Plaque, Dental, Postoperative Wound Infection, Purulent Gingivitis, Radiation Mucositis, Red eye, Ringworm, Skin Infections, Sore Throat, Stomatitis, Surgical Wounds, Tissue Damage, Tonsillitis, Ulcers, Leg, Wound Infections, Bacterial skin infections, Dry, cracked skin, Gum pain, Moderate Gingivitis, Oral infections, Oral lesions, Recurrent Oral fungal infection, Severe Gingivitis, Superficial Wounds, Throat disinfection, Tongue inflammation
Associated Therapies
Anesthesia of Mucous Membrane, Antimicrobial Therapy, Contact Lens Care, Disinfection, Disinfection of External Genitalia, Disinfection of the Urethra, Disinfection of the Vaginal Mucosa, Irrigation therapy, Lubrication of the Urethra, Oral Care, Oral Hygiene, Oropharyngeal antisepsis, Promotion of wound healing, Skin disinfection, Surgical Scrubbing, Topical Antisepsis, Urethral Anesthesia, Wound Cleansing, Oral antisepsis, Oral disinfection
Clinical Trials
Related News

A Clinical Trial for Chlorhexidine as Treatment for Vulvovaginal Candidiasis

First Posted Date
2021-09-28
Last Posted Date
2022-05-20
Lead Sponsor
Karolinska Institutet
Target Recruit Count
60
Registration Number
NCT05059145
Locations
🇸🇪

Danderyd Hospital, Dep. of Obstetrics and Gynecology, Stockholm, Sweden

Antiseptic Effects on the Dental Implant Internal Surface Microbiome

First Posted Date
2021-08-27
Last Posted Date
2023-01-20
Lead Sponsor
Madigan Army Medical Center
Target Recruit Count
150
Registration Number
NCT05024760
Locations
🇺🇸

Madigan Army Medical Center, Tacoma, Washington, United States

A 96-hour Patch Test Study Using Healthy Human Volunteers to Assess the Skin Irritation Potential of 11 Topically Applied Formulations

First Posted Date
2021-06-28
Last Posted Date
2021-06-28
Lead Sponsor
Molnlycke Health Care AB
Target Recruit Count
44
Registration Number
NCT04942496
Locations
🇺🇸

Bioscience Laboratories, Inc, Bozeman, Montana, United States

Hyaluronic Acid in Counteracting Aphthous Stomatitis

First Posted Date
2021-05-13
Last Posted Date
2021-07-22
Lead Sponsor
University of Urbino "Carlo Bo"
Target Recruit Count
49
Registration Number
NCT04884464
Locations
🇮🇹

University fo Urbino Carlo Bo, Urbino, Italy

Antiviral Efficacy and Acceptability of Mouth Rinses for Inactivation of COVID-19

First Posted Date
2021-02-10
Last Posted Date
2022-02-16
Lead Sponsor
University of North Carolina, Chapel Hill
Target Recruit Count
2
Registration Number
NCT04748783
Locations
🇺🇸

Adams School of Dentistry, Chapel Hill, North Carolina, United States

Topical Antisepsis in Head and Neck Cancer Surgery

Completed
Conditions
Head and Neck Cancer
First Posted Date
2021-01-22
Last Posted Date
2022-02-07
Lead Sponsor
Medical College of Wisconsin
Target Recruit Count
25
Registration Number
NCT04721626
Locations
🇺🇸

Froedtert Hospital & the Medical College of Wisconsin, Milwaukee, Wisconsin, United States

Evaluation of the Residual Antimicrobial Efficacy of One Test Material Based on a Modification of ASTM E1115-11 Test Method

Phase 4
Completed
Conditions
Hand Hygiene
Interventions
Drug: Chlorhexidine Gluconate
First Posted Date
2020-12-04
Last Posted Date
2021-02-25
Lead Sponsor
Molnlycke Health Care AB
Target Recruit Count
32
Registration Number
NCT04654182
Locations
🇺🇸

Bioscience Laboratories, Inc, Bozeman, Montana, United States

Efficacy of Zinc L-Carnosine Mouth Rinse

First Posted Date
2020-06-16
Last Posted Date
2020-06-18
Lead Sponsor
University of Milan
Target Recruit Count
75
Registration Number
NCT04430998
Locations
🇮🇹

UOC Maxillofacial Surgery and Odontology, University of Milan, Milan, Lombardy, Italy

Chlorhexidine and/or Betadine Prep in Pediatric Arm Surgery Following Trauma

First Posted Date
2020-01-13
Last Posted Date
2024-09-27
Lead Sponsor
Mark Seeley
Target Recruit Count
10
Registration Number
NCT04225065
Locations
🇺🇸

Geisinger Woodbine, Danville, Pennsylvania, United States

Animal-Assisted Visitation Program Chlorhexidine Trial

First Posted Date
2019-11-21
Last Posted Date
2024-07-10
Lead Sponsor
Johns Hopkins Bloomberg School of Public Health
Target Recruit Count
412
Registration Number
NCT04171817
Locations
🇺🇸

Washington University in St. Louis, Saint Louis, Missouri, United States

🇺🇸

Johns Hopkins, Baltimore, Maryland, United States

🇺🇸

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

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