Chlorhexidine

Generic Name
Chlorhexidine
Brand Names
Betasept, Hibiclens, Instillagel, Nupro Chlorhexidine, Oris, Oro-Clense, Paroex, Perichlor, Peridex, Periochip, Periogard, Prevora, X-pur
Drug Type
Small Molecule
Chemical Formula
C22H30Cl2N10
CAS Number
55-56-1
Unique Ingredient Identifier
R4KO0DY52L
Background

Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings a...

Indication

Chlorhexidine is available over-the-counter in various formulations (e.g. solution, sponge, cloth, swab) as a topical antiseptic to sanitize prior to surgeries and/or medical procedures. Dental formulations, available by prescription only, include an oral rinse indicated for the treatment of gingivitis and a slow-release "chip" which is inserted into periodo...

Associated Conditions
Aphthous ulcer, Catarrh of the throat, Chemotherapy Induced Oral Mucositis, Chronic Wounds, Decubitus Ulcer, Dental Cavity, Dysphagia, Eczema infected, Foeter Ex Ore, Gingival Bleeding, Gingival Diseases, Gingivitis, Glossitis, Hoarseness, Infection, Infectious Periodontal Diseases, Injury Throat, Mild to Moderate Inflammatory Reaction of the Oral Cavity, Mild to Moderate Inflammatory Reaction of the Pharynx, Mouth injury, Mucositis, Neurodermatitis, Ocular Inflammation, Ocular Irritation, Oral Aphthous Ulcer, Pain, Periodontitis, Pharyngitis, Plaque, Dental, Postoperative Wound Infection, Purulent Gingivitis, Radiation Mucositis, Red eye, Ringworm, Skin Infections, Sore Throat, Stomatitis, Surgical Wounds, Tissue Damage, Tonsillitis, Ulcers, Leg, Wound Infections, Bacterial skin infections, Dry, cracked skin, Gum pain, Moderate Gingivitis, Oral infections, Oral lesions, Recurrent Oral fungal infection, Severe Gingivitis, Superficial Wounds, Throat disinfection, Tongue inflammation
Associated Therapies
Anesthesia of Mucous Membrane, Antimicrobial Therapy, Contact Lens Care, Disinfection, Disinfection of External Genitalia, Disinfection of the Urethra, Disinfection of the Vaginal Mucosa, Irrigation therapy, Lubrication of the Urethra, Oral Care, Oral Hygiene, Oropharyngeal antisepsis, Promotion of wound healing, Skin disinfection, Surgical Scrubbing, Topical Antisepsis, Urethral Anesthesia, Wound Cleansing, Oral antisepsis, Oral disinfection
Clinical Trials
Related News

Comparative Evaluation of Chlorhexidine, Metronidazole and Combination Gels on Gingivitis

First Posted Date
2017-05-05
Last Posted Date
2017-05-05
Lead Sponsor
Aga Khan University
Target Recruit Count
90
Registration Number
NCT03142607
Locations
🇵🇰

Aga Khan University, Karachi, Sindh, Pakistan

Evaluating Safety and Effectiveness of Octenidine Dihydrochloride

First Posted Date
2017-05-04
Last Posted Date
2021-08-03
Lead Sponsor
CareFusion
Target Recruit Count
145
Registration Number
NCT03140254
Locations
🇺🇸

BioScience Laboratories, Butte, Montana, United States

Chlorhexidine Gluconate Versus Povidone-Iodine as Vaginal Preparation Antiseptics Prior to Cesarean Delivery

First Posted Date
2017-04-28
Last Posted Date
2019-03-11
Lead Sponsor
Metro Health, Michigan
Target Recruit Count
100
Registration Number
NCT03133312
Locations
🇺🇸

Metro Health, Wyoming, Michigan, United States

Garlic With Lime Juice and Chlorhexidine Mouthwash

First Posted Date
2017-04-10
Last Posted Date
2017-04-10
Lead Sponsor
Cairo University
Target Recruit Count
36
Registration Number
NCT03105960
Locations
🇪🇬

Manal Sayed Abdel Latief, Helwan, Cairo, Egypt

Cinnamon and Ginger in Comparison to Chlorhexidine Gluconate 0.2% on Oral Streptococcus Mutans

First Posted Date
2017-02-23
Last Posted Date
2017-02-23
Lead Sponsor
Cairo University
Target Recruit Count
21
Registration Number
NCT03061916
Locations
🇪🇬

Nadhel Ahmed Mukred Mohamed, Cairo Governorate, Cairo, Egypt

Mouthwash of Pomegranate Against Biofilm and Gingival Inflammation in School Children

Not Applicable
Completed
Conditions
Gingivitis
Interventions
Drug: Punica granatum Linn.
Drug: chlorhexidine
First Posted Date
2016-10-31
Last Posted Date
2016-10-31
Lead Sponsor
Universidade Estadual da Paraiba
Target Recruit Count
35
Registration Number
NCT02949583
Locations
🇧🇷

Universidade Estadual Da Paraiba, Campina Grande, Paraiba, Brazil

Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy

First Posted Date
2016-10-25
Last Posted Date
2019-07-31
Lead Sponsor
Cairo University
Target Recruit Count
40
Registration Number
NCT02943759
Locations
🇪🇬

Pediatric dentistry and Public health department-Cairo University, Cairo, Egypt

The Effect of Mouthwash Containing Pomegranate Peel Extract and Chlorhexidine Mouthwash on Bleeding on Brushing

First Posted Date
2016-10-19
Last Posted Date
2018-01-24
Lead Sponsor
Cairo University
Target Recruit Count
60
Registration Number
NCT02939092

Feasibility and Acceptability of Use of Daily Oral Rinse in Pregnant Women in Rural Nepal

First Posted Date
2016-06-02
Last Posted Date
2017-02-23
Lead Sponsor
Johns Hopkins Bloomberg School of Public Health
Target Recruit Count
175
Registration Number
NCT02788786
Locations
🇳🇵

Nepal Nutrition Intervention Project, Hariaun, Sarlahi District, Nepal

Effect of Oral Preparation on Bacterial Colonization of the Pharyngeal Mucosa in Surgery of Head and Neck Cancer

Phase 3
Completed
Conditions
Bacterial Infection
Interventions
Device: NaCl 0.9 %
Drug: Chlorhexidine
First Posted Date
2016-04-27
Last Posted Date
2018-12-20
Lead Sponsor
Rennes University Hospital
Target Recruit Count
80
Registration Number
NCT02753387
Locations
🇫🇷

Rennes University Hospital, Rennes, France

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