Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Post-Op Pain Control for Prophylactic Intramedullary Nailing.

Phase 3

Recruiting

Conditions: Bone Metastases
Lymphoma
Multiple Myeloma
Opioid Use
Pain

Interventions: Drug: Normal saline
Drug: Ketorolac
Drug: Acetaminophen
Drug: Oxycodone Acetaminophen
Drug: Morphine
Drug: Hydrocodone/Acetaminophen
Drug: Oxycodone

First Posted Date: 2019-01-30

Last Posted Date: 2024-11-06

Lead Sponsor: St. Louis University

Target Recruit Count: 60

Registration Number: NCT03823534

Locations: 🇺🇸
Saint Louis University, Saint Louis, Missouri, United States

Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels.

Phase 4

Completed

Conditions: Bariatric Surgery Candidate
Glucose Intolerance
Insulin Resistance

Interventions: Drug: 0.9% Sodium-chloride
Drug: Dexmedetomidine
Drug: Fentanyl
Drug: Morphine Sulfate

First Posted Date: 2019-01-18

Last Posted Date: 2020-10-01

Lead Sponsor: Pontificia Universidad Catolica de Chile

Target Recruit Count: 40

Registration Number: NCT03809182

Tramadol Versus Placebo and Morphine in the Management of Post-Operative Pain Abdominoplasty

Phase 3

Active, not recruiting

Conditions: Pain Management

Interventions: Drug: Tramadol
Drug: Morphine
Other: Placebo

First Posted Date: 2018-12-13

Last Posted Date: 2019-05-09

Lead Sponsor: Avenue Therapeutics, Inc.

Target Recruit Count: 360

Registration Number: NCT03774836

Locations: 🇺🇸
Lotus Clinical Research, Pasadena, California, United States
🇺🇸
Hermann Drive Research, Houston, Texas, United States
🇺🇸
Endeavor Clinical Trials, San Antonio, Texas, United States

Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)

Phase 4

Completed

Conditions: Opioid Use
Pain, Postoperative

Interventions: Drug: Methadone
Drug: Fentanyl
Drug: Hydromorphone
Drug: Morphine
Drug: Sufentanil

First Posted Date: 2018-10-31

Last Posted Date: 2024-02-02

Lead Sponsor: Duke University

Target Recruit Count: 907

Registration Number: NCT03726268

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

Spinal Anesthesia For Enhanced Recovery After Liver Surgery

Not Applicable

Recruiting

Conditions: Pain, Postoperative
Hepatectomy
Liver Neoplasms

Interventions: Procedure: Spinal anesthesia with intrathecal morphine
Procedure: Continuous thoracic epidural analgesia
Drug: Bupivacaine 0.75% in Dextrose Inj 8.25%
Drug: Bupivacaine 0.25% Preservative-Free Injectable Solution
Drug: Morphine
Drug: Bupicavaine 0.125% epidural solution
Drug: Hydromorphone 10 mcg/mL epidural solution

First Posted Date: 2018-10-23

Last Posted Date: 2023-12-07

Lead Sponsor: University of Manitoba

Target Recruit Count: 128

Registration Number: NCT03715517

Locations: 🇨🇦
University of Manitoba, Winnipeg, Manitoba, Canada

Comparison of the Efficacy and Safety of NALDEBAIN With Conventional Treatment After Laparoscopic Cholecystectomy

Phase 4

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Naldebain
Drug: Morphine

First Posted Date: 2018-10-19

Last Posted Date: 2020-07-16

Lead Sponsor: Cathay General Hospital

Target Recruit Count: 44

Registration Number: NCT03713216

Locations: 🇨🇳
Cathay General Hospital, Taipei, Taiwan

Influence of Opioid Analgesia on Circulating Tumor Cells in Laparoscopic Colorectal Cancer Surgery

Phase 4

Completed

Conditions: Circulating Tumor Cell
Colorectal Cancer

Interventions: Drug: Piritramid
Drug: Morphine

First Posted Date: 2018-10-09

Last Posted Date: 2023-12-07

Lead Sponsor: The Institute of Molecular and Translational Medicine, Czech Republic

Target Recruit Count: 71

Registration Number: NCT03700541

Locations: 🇨🇿
General University Hospital, Prague, Czechia
🇨🇿
T. Bata Regional Hospital Zlin, Zlin, Jihomoravsky Kraj, Czechia
🇨🇿
University Hospital Ostrava, Ostrava, Czechia

Influence of Opioid Analgesia on Circulating Tumor Cells in Open Colorectal Cancer Surgery

Phase 4

Completed

Conditions: Circulating Tumor Cell
Colorectal Cancer

Interventions: Drug: Epidural
Drug: Piritramid
Drug: Morphine

First Posted Date: 2018-10-09

Last Posted Date: 2023-12-07

Lead Sponsor: The Institute of Molecular and Translational Medicine, Czech Republic

Target Recruit Count: 125

Registration Number: NCT03700411

Locations: 🇨🇿
T. Bata Regional Hospital Zlin, Zlin, Jihomoravsky Kraj, Czechia
🇨🇿
University Hospital Ostrava, Ostrava, Czechia
🇨🇿
General University Hospital, Prague, Czechia