Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Comparison of Three Opioid Detoxification Treatment Regimens

Phase 3

Withdrawn

Conditions: Opioid-Related Disorders
Opioid Withdrawal

Interventions: Drug: Buprenorphine/naloxone
Drug: Morphine
Drug: Tramadol

First Posted Date: 2018-09-20

Last Posted Date: 2019-11-05

Lead Sponsor: University of Alabama at Birmingham

Registration Number: NCT03678792

Locations: 🇺🇸
Virginia Commonwealth University, Richmond, Virginia, United States

Spinal Morphine for Postoperative Analgesia in Urology

Phase 4

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Morphine

First Posted Date: 2018-09-18

Last Posted Date: 2018-09-19

Lead Sponsor: Charles University, Czech Republic

Target Recruit Count: 98

Registration Number: NCT03675646

Locations: 🇨🇿
University Hospital Kralovske Vinohrady, Praha, Czechia

Ketamine Versus Morphine Change Pain Profile

Not Applicable

Completed

Conditions: Acute Pain

Interventions: Drug: Ketamine
Drug: Morphine

First Posted Date: 2018-09-10

Last Posted Date: 2020-06-29

Lead Sponsor: Cairo University

Target Recruit Count: 160

Registration Number: NCT03664622

Locations: 🇪🇬
Cairo University, Cairo, Giza, Egypt

Postoperative Analgesic Effect of Hydromorphone on Partial Pulmonary Resection Under Video-assisted Thoracoscopy

Phase 4

Completed

Conditions: Thoracic Surgery, Video-Assisted
Pain, Postoperative

Interventions: Drug: Morphine
Drug: Hydromorphone

First Posted Date: 2018-08-27

Last Posted Date: 2018-09-26

Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Target Recruit Count: 171

Registration Number: NCT03648008

Locations: 🇨🇳
The second affiliated hospital of Zhejiang University, Hangzhou, Zhejiang, China

The Effect of the Transversus Abdominis Plane Block to Postoperative Analgesia for Cesarean Section

Not Applicable

Completed

Conditions: Obstetric Pain

Interventions: Procedure: TAP block
Drug: Morphine
Drug: Ropivacaine

First Posted Date: 2018-08-16

Last Posted Date: 2018-08-16

Lead Sponsor: Gia Dinh People Hospital

Target Recruit Count: 60

Registration Number: NCT03634111

Locations: 🇻🇳
THANG Nguyen Trong, Ho Chi Minh, Vietnam

Comparing Protocols for Analgesia Following Elective Cesarean Section

Phase 4

Conditions: Post-Cesarean Section
Postoperative Pain

Interventions: Drug: Acetaminophen
Drug: Ibuprofen 400 mg
Drug: Dipyrone
Drug: Tramadol
Drug: Tramal
Drug: Morphine

First Posted Date: 2018-08-09

Last Posted Date: 2018-08-09

Lead Sponsor: Wolfson Medical Center

Target Recruit Count: 120

Registration Number: NCT03622489

Locations: 🇮🇱
Wolfson medical center, Holon, Israel

Neurotoxic Adverse Effects of Morphine and Oxycodone for Pain in Terminal Patients With Diminished Renal Function

Phase 4

Terminated

Conditions: Pain
Terminal Illness
Renal Impairment

Interventions: Drug: Oxycodone
Drug: Morphine

First Posted Date: 2018-08-06

Last Posted Date: 2019-03-18

Lead Sponsor: Maastricht University Medical Center

Target Recruit Count: 8

Registration Number: NCT03616639

Locations: 🇳🇱
Envida - Koepelhof, Maastricht, Limburg, Netherlands
🇳🇱
Envida - Grubbeveld, Maastricht, Limburg, Netherlands
🇳🇱
Envida - La Valence, Maastricht, Limburg, Netherlands

and more 12 locations