Morphine
- Generic Name
- Morphine
- Brand Names
- Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 57-27-2
- Unique Ingredient Identifier
- 76I7G6D29C
- Background
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.
Morphine was granted FDA approval in 1941.
- Indication
Morphine is used for the management of chronic, moderate to severe pain.
Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.
- Associated Conditions
- Chronic Pain, Severe Pain
- Associated Therapies
- -
The Effect of Chlorzoxazone on Moderate to Severe Postoperative Pain After Spine Surgery
- Conditions
- Interventions
- First Posted Date
- 2013-09-02
- Last Posted Date
- 2015-09-17
- Lead Sponsor
- Rigshospitalet, Denmark
- Target Recruit Count
- 110
- Registration Number
- NCT01933542
- Locations
- 🇩🇰
Glostrup University Hospital, Glostrup, Denmark
Opioid Effects on Swallowing Comparing Younger and Elderly Volunteers
- Conditions
- Interventions
- First Posted Date
- 2013-08-16
- Last Posted Date
- 2014-12-03
- Lead Sponsor
- Region Örebro County
- Target Recruit Count
- 18
- Registration Number
- NCT01924234
- Locations
- 🇸🇪
Örebro University Hospital, Örebro, Sweden
Adding Intra-articular Dexmedetomidine to Levobupivacaine for Postoperative Analgesia in Arthroscopic Knee Surgery
- First Posted Date
- 2013-08-08
- Last Posted Date
- 2013-08-08
- Lead Sponsor
- TC Erciyes University
- Target Recruit Count
- 60
- Registration Number
- NCT01918917
Different Lipid Soluble Opioids for Gynecologic Laparoscopic Surgery Postoperative Patient-controlled Analgesia
- Conditions
- Interventions
- First Posted Date
- 2013-08-06
- Last Posted Date
- 2013-08-06
- Lead Sponsor
- Peking University First Hospital
- Target Recruit Count
- 180
- Registration Number
- NCT01917045
Low-dose Spinal Morphine for Post-Thoracotomy Pain After Video-Assisted Thoracoscopic Surgery
- Conditions
- Interventions
- First Posted Date
- 2013-08-06
- Last Posted Date
- 2016-04-08
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 36
- Registration Number
- NCT01917448
- Locations
- 🇹🇭
Faculty of Medicine, Siriraj Hospital, mahidol University, Bangkok, Thailand
Prediction of Inter-individual Differences in the Response to Morphine Versus Milnacipran in Patients With Sciatica
- First Posted Date
- 2013-08-01
- Last Posted Date
- 2019-04-02
- Lead Sponsor
- Rambam Health Care Campus
- Target Recruit Count
- 150
- Registration Number
- NCT01914042
- Locations
- 🇮🇱
Rambam Health Care Campus, Haifa, Israel
Comparing the Analgesic Effect of Intravenous Acetaminophen and Morphine on Patients With Renal Colic Pain Reffering to the Emergency Department: A Randomized Controlled Trial
- First Posted Date
- 2013-07-24
- Last Posted Date
- 2013-07-24
- Lead Sponsor
- Seyed Mehdi Pourafzali
- Target Recruit Count
- 124
- Registration Number
- NCT01906762
Ketamine and Morphine Versus Morphine Alone for the Treatment of Acute Pain in the Emergency Department
- First Posted Date
- 2013-07-17
- Last Posted Date
- 2023-07-17
- Lead Sponsor
- University of Arizona
- Target Recruit Count
- 17
- Registration Number
- NCT01900847
- Locations
- 🇺🇸
University of Arizona Health Network University Campus 1501 North Campbell Ave, Tucson, Arizona, United States
Non-opioid Analgesic Combination With Morphine for Postoperative Analgesia.
- Conditions
- Interventions
- First Posted Date
- 2013-06-20
- Last Posted Date
- 2018-02-06
- Lead Sponsor
- Rennes University Hospital
- Target Recruit Count
- 223
- Registration Number
- NCT01882530
- Locations
- 🇫🇷
Marcel Chauvin, Boulogne, France
🇫🇷Xavier Capdevila, Montpellier, France
🇫🇷Hawa Keita-Meyer, Colombes, France
Genetic Effects on Dopamine Response to an Opiate
- First Posted Date
- 2013-06-14
- Last Posted Date
- 2021-04-01
- Target Recruit Count
- 15
- Registration Number
- NCT01878006
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Drug Development Updates
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