Ibuprofen

Generic Name: Ibuprofen

Brand Names: Addaprin, Advil, Advil Cold and Sinus, Advil Congestion Relief, Advil PM, Advil Sinus Congestion and Pain, Alivio, Caldolor, Cedaprin, Children's Ibuprofen, Diphen, Duexis, Ibu, Ibutab, Junior Strength Motrin, Motrin, Motrin PM, Neoprofen, Nuprin, Pedea, Proprinal, Reprexain, Sudafed PE Head Congestion Plus Pain, Vicoprofen, Wal-profen Congestion Relief and Pain, Ibuprofen Gen.Orph

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₈O_₂

CAS Number: 15687-27-1

Unique Ingredient Identifier: WK2XYI10QM

Background: Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.

On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.

Indication: Ibuprofen is the most commonly used and prescribed NSAID. It is a very common over-the-counter medication widely used as an analgesic, anti-inflammatory and antipyretic.

The use of ibuprofen and its enantiomer Dexibuprofen in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.

Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labour.

As ibuprofen is a widely used medication, the main therapeutic indications are:

Associated Conditions: Acute Pain, Ankylosing Spondylitis (AS), Common Cold, Cystic Fibrosis (CF), Fever, Gastric Ulcer, Gout, Headache, Insomnia, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Migraine, Mild pain, Nasal Congestion, Osteoarthritis (OA), Pain, Pain, Inflammatory, Patent Ductus Arteriosus (PDA), Pericarditis, Primary Dysmenorrhoea, Rheumatoid Arthritis, Severe Pain, Sinus pressure, Mild to moderate pain, Minor aches and pains, Moderate Pain

Clinical Trials

Pain Control Without Opioids

Phase 3

Withdrawn

Conditions: Perioperative Pain

Interventions: Drug: Ibuprofen 600 mg
Drug: OxyCODONE 5 Mg Oral Capsule

First Posted Date: 2021-03-24

Last Posted Date: 2022-09-10

Lead Sponsor: Hackensack Meridian Health

Registration Number: NCT04813991

Locations: 🇺🇸
Hackensack University Medical Center, Hackensack, New Jersey, United States

Non-Opioid Pain Medications After Intracapsular Adenotonsillectomy

Phase 1

Terminated

Conditions: Adenotonsillectomy
Opioid Use
Post-operative Analgesia

Interventions: Drug: Oxycodone
Drug: Ibuprofen
Drug: Acetaminophen
Other: Opioid disposal education
Other: Opioid disposal pouch

First Posted Date: 2021-03-10

Last Posted Date: 2024-08-16

Lead Sponsor: David Chi, MD

Target Recruit Count: 73

Registration Number: NCT04791761

Locations: 🇺🇸
UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States

Pain Management During Screening for Retinopathy of Prematurity

Completed

Conditions: Retinopathy of Prematurity
Pain Management

Interventions: Drug: Ibuprofen (Sanofi, Istanbul, Turkey)
Drug: Paracetamol (GlaxoSmithKline, Istanbul, Turkey)

First Posted Date: 2021-02-23

Last Posted Date: 2021-02-23

Lead Sponsor: Istanbul Medeniyet University

Target Recruit Count: 44

Registration Number: NCT04767178

Locations: 🇹🇷
Medeniyet University, Istanbul, Turkey

Comparative Analgesic Effects of Paracetamol/Codeine and Ibuprofen on Pain After Third Molar Surgery

Phase 4

Completed

Conditions: To Control Pain After Third Molar Surgery

Interventions: Drug: paracetamol 500 mg plus codeine 30 mg preoperative administration
Drug: ibuprofen 400 mg preoperative administration
Drug: Placebo oral tablet preoperative administration

First Posted Date: 2021-01-29

Last Posted Date: 2021-01-29

Lead Sponsor: University of Roma La Sapienza

Target Recruit Count: 120

Registration Number: NCT04730297

Locations: 🇮🇹
Maria Paola Cristalli, Roma, Italy

Ibuprofen Versus Indomethacin Following Emergent Cerclage Placement

Not Applicable

Conditions: Preterm Labor

Interventions: Drug: Ibuprofen 2400mg
Drug: Indomethacin 150mg

First Posted Date: 2021-01-27

Last Posted Date: 2023-12-05

Lead Sponsor: Woman's

Target Recruit Count: 100

Registration Number: NCT04726085

Locations: 🇺🇸
Woman's Hospital, Baton Rouge, Louisiana, United States

Efficacy of Intravenous Paracetamol and Ibuprofen on Postoperative Pain and Morphine Consumption in Hysterectomy

Not Applicable

Completed

Conditions: Postoperative Pain Management

Interventions: Drug: Morphine Sulfate
Drug: Intravenous ibuprofen
Drug: Intravenous paracetamol
Drug: Morphine

First Posted Date: 2020-12-31

Last Posted Date: 2022-03-11

Lead Sponsor: Inonu University

Target Recruit Count: 66

Registration Number: NCT04691856

Locations: 🇹🇷
Sedat Akbas, Malatya, Türkiye-Türkçe, Turkey

Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malignancies

Phase 1

Active, not recruiting

Conditions: Recurrent Acute Leukemia
Recurrent B Acute Lymphoblastic Leukemia
Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm
Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Refractory Hairy Cell Leukemia
Refractory Hematologic Malignancy
Refractory Hodgkin Lymphoma
Refractory T Acute Lymphoblastic Leukemia
Systemic Mastocytosis