Ibuprofen

Generic Name: Ibuprofen

Brand Names: Addaprin, Advil, Advil Cold and Sinus, Advil Congestion Relief, Advil PM, Advil Sinus Congestion and Pain, Alivio, Caldolor, Cedaprin, Children's Ibuprofen, Diphen, Duexis, Ibu, Ibutab, Junior Strength Motrin, Motrin, Motrin PM, Neoprofen, Nuprin, Pedea, Proprinal, Reprexain, Sudafed PE Head Congestion Plus Pain, Vicoprofen, Wal-profen Congestion Relief and Pain, Ibuprofen Gen.Orph

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₈O_₂

CAS Number: 15687-27-1

Unique Ingredient Identifier: WK2XYI10QM

Background: Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.

On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.

Indication: Ibuprofen is the most commonly used and prescribed NSAID. It is a very common over-the-counter medication widely used as an analgesic, anti-inflammatory and antipyretic.

The use of ibuprofen and its enantiomer Dexibuprofen in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.

Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labour.

As ibuprofen is a widely used medication, the main therapeutic indications are:

Associated Conditions: Acute Pain, Ankylosing Spondylitis (AS), Common Cold, Cystic Fibrosis (CF), Fever, Gastric Ulcer, Gout, Headache, Insomnia, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Migraine, Mild pain, Nasal Congestion, Osteoarthritis (OA), Pain, Pain, Inflammatory, Patent Ductus Arteriosus (PDA), Pericarditis, Primary Dysmenorrhoea, Rheumatoid Arthritis, Severe Pain, Sinus pressure, Mild to moderate pain, Minor aches and pains, Moderate Pain

Clinical Trials

RCT, Blinded, 2-Arm Efficacy Study of IP and Placebo in Patients With Chronic Pain Related to Osteoarthritis of the Knee

Phase 3

Conditions: Degenerative Arthritis

Interventions: Drug: Placebo
Drug: Ibuprofen modified release tablet 800 mg

First Posted Date: 2022-04-08

Last Posted Date: 2022-04-14

Lead Sponsor: Overseas Pharmaceuticals, Ltd.

Target Recruit Count: 500

Registration Number: NCT05318521

Locations: 🇺🇸
Palm Beach Research Center, West Palm Beach, Florida, United States

Effect of Combination Non Steroidal Antiinflammatory Drugs and Narrowband UVB Treatment in Non-Photoadapters

Not Applicable

Terminated

Conditions: Vitiligo

Interventions: Drug: Ibuprofen

First Posted Date: 2022-02-25

Last Posted Date: 2022-02-25

Lead Sponsor: Henry Ford Health System

Target Recruit Count: 3

Registration Number: NCT05256147

Locations: 🇺🇸
Henry Ford Dermatology, Detroit, Michigan, United States

Efficacy of the Combination of Ibuprofen and Paracetamol in Acute Non-specific Low Back Pain

Phase 4

Completed

Conditions: Low Back Pain

Interventions: Drug: Brufen
Drug: Tachifene

First Posted Date: 2022-02-03

Last Posted Date: 2023-01-31

Lead Sponsor: Aziende Chimiche Riunite Angelini Francesco S.p.A

Target Recruit Count: 176

Registration Number: NCT05222724

Locations: 🇵🇱
In-Vivo sp z o. o., Bydgoszcz, Poland
🇵🇱
Przychodnia "Przy Szapitalu", Bydgoszcz, Poland
🇵🇱
Zespół Porani Specjalistycznych Reumed Filia nr 1 Wallenroda, Lublin, Poland

and more 8 locations

Ibuprofen Versus Ketorolac for Pain Relief During Hysterosalpingogram

Phase 4

Terminated

Conditions: Infertility, Female

Interventions: Drug: Ibuprofen 800 mg oral
Drug: Ketorolac 30mg oral

First Posted Date: 2022-01-13

Last Posted Date: 2024-12-24

Lead Sponsor: Madigan Army Medical Center

Target Recruit Count: 12

Registration Number: NCT05190341

Locations: 🇺🇸
Madigan Army Medical Center, Tacoma, Washington, United States

Efficacy of Chronoterapy in Oral Surgery

Not Applicable

Completed

Conditions: Tooth, Impacted
Trismus
Pain
Inflammatory Response

Interventions: Drug: Ibuprofen 400 mg

First Posted Date: 2021-11-18

Last Posted Date: 2022-02-03

Lead Sponsor: Universidad Complutense de Madrid

Target Recruit Count: 10

Registration Number: NCT05126264

Locations: 🇪🇸
Fabian Perez Gonzalez, Madrid, Spain

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE. Master Protocol HTX-011-401.

Phase 4

Active, not recruiting

Conditions: Analgesia

Interventions: Drug: HTX-011
Drug: Bupivacaine Hydrochloride
Device: Luer lock applicator
Drug: Ibuprofen
Drug: Acetaminophen

First Posted Date: 2021-11-05

Last Posted Date: 2023-10-26

Lead Sponsor: Heron Therapeutics

Target Recruit Count: 90

Registration Number: NCT05109312

Locations: 🇺🇸
Endeavor Clinical Trials, LLC, San Antonio, Texas, United States
🇺🇸
First Surgical Hospital, Bellaire, Texas, United States
🇺🇸
Legent Orthopedic Hospital, Carrollton, Texas, United States

and more 4 locations