Ibuprofen

Generic Name: Ibuprofen

Brand Names: Addaprin, Advil, Advil Cold and Sinus, Advil Congestion Relief, Advil PM, Advil Sinus Congestion and Pain, Alivio, Caldolor, Cedaprin, Children's Ibuprofen, Diphen, Duexis, Ibu, Ibutab, Junior Strength Motrin, Motrin, Motrin PM, Neoprofen, Nuprin, Pedea, Proprinal, Reprexain, Sudafed PE Head Congestion Plus Pain, Vicoprofen, Wal-profen Congestion Relief and Pain, Ibuprofen Gen.Orph

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₈O_₂

CAS Number: 15687-27-1

Unique Ingredient Identifier: WK2XYI10QM

Background: Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.

On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.

Indication: Ibuprofen is the most commonly used and prescribed NSAID. It is a very common over-the-counter medication widely used as an analgesic, anti-inflammatory and antipyretic.

The use of ibuprofen and its enantiomer Dexibuprofen in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.

Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labour.

As ibuprofen is a widely used medication, the main therapeutic indications are:

Associated Conditions: Acute Pain, Ankylosing Spondylitis (AS), Common Cold, Cystic Fibrosis (CF), Fever, Gastric Ulcer, Gout, Headache, Insomnia, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Migraine, Mild pain, Nasal Congestion, Osteoarthritis (OA), Pain, Pain, Inflammatory, Patent Ductus Arteriosus (PDA), Pericarditis, Primary Dysmenorrhoea, Rheumatoid Arthritis, Severe Pain, Sinus pressure, Mild to moderate pain, Minor aches and pains, Moderate Pain

Clinical Trials

Ibuprofen Liquid Capsules 2 x 200 mg Efficacy and PK/PD Study in Surgical Removal of Impacted Third Molars

Phase 3

Completed

Conditions: Tooth, Impacted
Tooth Diseases
Stomatognathic Diseases

Interventions: Drug: Ibuprofen 200Mg Oral Cap
Drug: Ibuprofen 200Mg Oral Tablet
Other: Placebo Tablets
Other: Placebo Liquid Capsule

First Posted Date: 2022-08-02

Last Posted Date: 2023-06-22

Lead Sponsor: Reckitt Benckiser Healthcare (UK) Limited

Target Recruit Count: 294

Registration Number: NCT05484401

Locations: 🇺🇸
JBR Clinical Research, Salt Lake City, Utah, United States

Evaluation the Effect of Using Preoperative Ibuprofen Versus Low Level Laser Therapy on Inferior Alveolar Nerve Block

Not Applicable

Conditions: Postoperative Pain

Interventions: Device: Nonactive Diode laser
Device: Diode laser
Drug: Ibuprofen

First Posted Date: 2022-07-29

Last Posted Date: 2022-07-29

Lead Sponsor: Yuzuncu Yıl University

Target Recruit Count: 76

Registration Number: NCT05479175

Locations: 🇹🇷
Yuzuncu Yıl University, Van, Turkey

Pharmacokinetic Interaction Between Ibuprofen and Acetaminophen Oral Suspension

Phase 1

Completed

Conditions: Healthy

First Posted Date: 2022-06-23

Last Posted Date: 2022-06-28

Lead Sponsor: Laboratorios Silanes S.A. de C.V.

Target Recruit Count: 42

Registration Number: NCT05428293

Locations: 🇲🇽
Laboratorio Silanes, S.A. de C.V., Mexico City, Mexico

Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Tramadol Consumption in Shoulder Surgery

Not Applicable

Completed

Conditions: Postoperative Pain Management

Interventions: Drug: Tramadol
Drug: Paracetamol
Drug: Ibuprofen

First Posted Date: 2022-06-02

Last Posted Date: 2023-08-18

Lead Sponsor: Bezmialem Vakif University

Target Recruit Count: 2

Registration Number: NCT05401916

Locations: 🇹🇷
Muhittin Calim, Istanbul, Fatih, Turkey

Chiropractic Spinal Manipulative Therapy for Acute Neck Pain

Phase 4

Recruiting

Conditions: Acute Neck Pain

Interventions: Drug: Placebo medication
Drug: Ibuprofen
Other: Chiropractic spinal manipulative therapy (CSMT)
Other: CSMT sham manipulation

First Posted Date: 2022-05-13

Last Posted Date: 2023-08-08

Lead Sponsor: University Hospital, Akershus

Target Recruit Count: 320

Registration Number: NCT05374057

Locations: 🇳🇴
Michael B. Russell, Oslo, Norway

Pain Multidisciplinar Intervention in Major Trauma Patients

Completed

Conditions: Trauma
Chronic Pain
Psychological Trauma

Interventions: Drug: Paracetamol
Drug: Ibuprofen 600 mg
Drug: Tramadol
Drug: Morphine

First Posted Date: 2022-05-02

Last Posted Date: 2025-02-12

Lead Sponsor: Nuria Llorach-Perucho

Target Recruit Count: 38

Registration Number: NCT05355441

Locations: 🇪🇸
Corporació Sanitària Parc Taulí, Sabadell, Barcelona, Spain

Effect of Cryotherapy Versus Post-operative Ibuprofen Medication on Post-operative Pain in Mandibular Molar Teeth With Symptomatic Irreversible Pulpitis

Phase 1

Conditions: Symptomatic Irreversible Pulpitis

Interventions: Drug: Ibuprofen 400 mg
Other: cold saline (cryotherapy)
Other: Final irrigation with normal saline

First Posted Date: 2022-04-22

Last Posted Date: 2022-04-22

Lead Sponsor: Cairo University

Target Recruit Count: 36

Registration Number: NCT05341999

Co-administration of Acetaminophen with Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants

Phase 2

Recruiting

Conditions: Patent Ductus Arteriosus After Premature Birth

Interventions: Drug: Acetaminophen Injection
Drug: Ibuprofen 20 mg/mL oral suspension or Ibuprofen lysine 10 mg/mL injection solution (Neoprofen)
Other: Sodium chloride 0.9% injection

First Posted Date: 2022-04-22

Last Posted Date: 2025-02-12

Lead Sponsor: Mount Sinai Hospital, Canada

Target Recruit Count: 310

Registration Number: NCT05340582

Locations: 🇦🇺
John Hunter Hospital, Newcastle, New South Wales, Australia
🇦🇺
Royal North Shore Hospital, St Leonards, New South Wales, Australia
🇨🇦
Royal Alexandra Hospital, Edmonton, Ontario, Canada

and more 6 locations