Ibuprofen

Generic Name: Ibuprofen

Brand Names: Addaprin, Advil, Advil Cold and Sinus, Advil Congestion Relief, Advil PM, Advil Sinus Congestion and Pain, Alivio, Caldolor, Cedaprin, Children's Ibuprofen, Diphen, Duexis, Ibu, Ibutab, Junior Strength Motrin, Motrin, Motrin PM, Neoprofen, Nuprin, Pedea, Proprinal, Reprexain, Sudafed PE Head Congestion Plus Pain, Vicoprofen, Wal-profen Congestion Relief and Pain, Ibuprofen Gen.Orph

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₈O_₂

CAS Number: 15687-27-1

Unique Ingredient Identifier: WK2XYI10QM

Background: Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first ...

Indication: Ibuprofen is the most commonly used and prescribed NSAID. It is a very common over-the-counter medication widely used as an analgesic, anti-inflammatory and antipyretic.
...

Associated Conditions: Acute Pain, Ankylosing Spondylitis (AS), Common Cold, Cystic Fibrosis (CF), Fever, Gastric Ulcer, Gout, Headache, Insomnia, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Migraine, Mild pain, Nasal Congestion, Osteoarthritis (OA), Pain, Pain, Inflammatory, Patent Ductus Arteriosus (PDA), Pericarditis, Primary Dysmenorrhoea, Rheumatoid Arthritis, Severe Pain, Sinus pressure, Mild to moderate pain, Minor aches and pains, Moderate Pain

Associated Therapies: -

Clinical Trials

Aggressive Antipyretics for Fever Reduction in CNS Malaria

Phase 2

Completed

Conditions: Fever
Parasitemia
Malaria
Seizures
Coma
Hyperpyrexia

Interventions: Drug: placebo for acetaminophen
Drug: Acetaminophen
Drug: placebo for ibuprofen
Drug: Ibuprofen

First Posted Date: 2018-01-16

Last Posted Date: 2024-03-05

Lead Sponsor: University of Rochester

Target Recruit Count: 256

Registration Number: NCT03399318

Locations: 🇲🇼
Pediatric Research Ward at Queen Elizabeth Central Hospital, Blantyre, Malawi
🇿🇲
Chipata Central Hospital, Chipata, Eastern, Zambia
🇿🇲
University Teaching Hospital's Lusaka Childrens Hospital, Lusaka, Zambia

Postoperative Ibuprofen Use and Risk of Bleeding in Pediatric Tonsillectomy

Phase 1

Withdrawn

Conditions: Tonsillectomy With or Without Adenoidectomy

Interventions: Drug: Ibuprofen
Drug: Acetaminophen

First Posted Date: 2017-12-28

Last Posted Date: 2018-09-20

Lead Sponsor: Massachusetts Eye and Ear Infirmary

Registration Number: NCT03385057

Locations: 🇺🇸
Rady's Children's Hospital, San Diego, California, United States
🇺🇸
Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia, United States
🇺🇸
Case Western University- Raimbow Babies and Children's, Cleveland, Ohio, United States

and more 2 locations

Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section

Phase 4

Completed

Conditions: Opioid Use
Pain, Postoperative

Interventions: Drug: Ibuprofen
Drug: Acetaminophen
Drug: Norco

First Posted Date: 2017-12-13

Last Posted Date: 2019-07-02

Lead Sponsor: The University of Texas Health Science Center, Houston

Target Recruit Count: 170

Registration Number: NCT03372382

Locations: 🇺🇸
The University of Texas Health Science Center at Houston, Houston, Texas, United States

Paracetamol Versus Ibuprofen for PDA Closure

Phase 4

Conditions: Patent Ductus Arteriosus

Interventions: Drug: ibuprofen
Drug: paracetamol

First Posted Date: 2017-08-29

Last Posted Date: 2017-08-29

Lead Sponsor: Ain Shams University

Target Recruit Count: 30

Registration Number: NCT03265782

Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial

Phase 2

Completed

Conditions: Hand, Foot and Mouth Disease
Herpangina
Gingivostomatitis

Interventions: Drug: Sucralfate
Other: Placebo
Drug: Acetaminophen
Drug: Ibuprofen

First Posted Date: 2017-08-07

Last Posted Date: 2021-10-29

Lead Sponsor: University of Texas at Austin

Target Recruit Count: 102

Registration Number: NCT03241030

Locations: 🇺🇸
Dell Children's Medical Center, Austin, Texas, United States

COMBOPROFEN for Treatment of Muscular Pain Associated With Delayed Onset Muscle Soreness (DOMS)

Phase 2

Completed

Conditions: Delayed Onset Muscle Soreness, DOMS

Interventions: Drug: Placebo
Drug: Comboprofen
Drug: Magnesium
Drug: Ibuprofen
Drug: Vitamin C

First Posted Date: 2017-07-21

Last Posted Date: 2018-01-23

Lead Sponsor: Spherium Biomed

Target Recruit Count: 74

Registration Number: NCT03223519

Locations: 🇪🇸
Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Cancer

Phase 2

Completed

Conditions: Cognitive Impairment
Malignant Neoplasm

Interventions: Other: Placebo
Drug: Ibuprofen
Other: Questionnaire Administration

First Posted Date: 2017-06-14

Last Posted Date: 2023-09-25

Lead Sponsor: University of Rochester NCORP Research Base

Target Recruit Count: 87

Registration Number: NCT03186638

Locations: 🇺🇸
Saint Luke's Mountain States Tumor Institute - Nampa, Nampa, Idaho, United States
🇺🇸
Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois, United States
🇺🇸
Illinois CancerCare-Galesburg, Galesburg, Illinois, United States

and more 166 locations