Ibuprofen

Generic Name
Ibuprofen
Brand Names
Addaprin, Advil, Advil Cold and Sinus, Advil Congestion Relief, Advil PM, Advil Sinus Congestion and Pain, Alivio, Caldolor, Cedaprin, Children's Ibuprofen, Diphen, Duexis, Ibu, Ibutab, Junior Strength Motrin, Motrin, Motrin PM, Neoprofen, Nuprin, Pedea, Proprinal, Reprexain, Sudafed PE Head Congestion Plus Pain, Vicoprofen, Wal-profen Congestion Relief and Pain, Ibuprofen Gen.Orph
Drug Type
Small Molecule
Chemical Formula
C13H18O2
CAS Number
15687-27-1
Unique Ingredient Identifier
WK2XYI10QM
Background

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.

On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.

Indication

Ibuprofen is the most commonly used and prescribed NSAID. It is a very common over-the-counter medication widely used as an analgesic, anti-inflammatory and antipyretic.

The use of ibuprofen and its enantiomer Dexibuprofen in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.

Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labour.

As ibuprofen is a widely used medication, the main therapeutic indications are:

Associated Conditions
Acute Pain, Ankylosing Spondylitis (AS), Common Cold, Cystic Fibrosis (CF), Fever, Gastric Ulcer, Gout, Headache, Insomnia, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Migraine, Mild pain, Nasal Congestion, Osteoarthritis (OA), Pain, Pain, Inflammatory, Patent Ductus Arteriosus (PDA), Pericarditis, Primary Dysmenorrhoea, Rheumatoid Arthritis, Severe Pain, Sinus pressure, Mild to moderate pain, Minor aches and pains, Moderate Pain
Associated Therapies
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A Selective COX-2 Inhibitor Provides Pain Control But Hinders Healing Following Arthroscopic Rotator Cuff Repair

First Posted Date
2016-07-29
Last Posted Date
2016-07-29
Lead Sponsor
Seoul National University Bundang Hospital
Target Recruit Count
180
Registration Number
NCT02850211

Analgesia and Physiotherapy in Children With Cerebral Palsy (ANTALKINECP)

Phase 3
Terminated
Conditions
Interventions
First Posted Date
2016-07-21
Last Posted Date
2018-09-27
Lead Sponsor
University Hospital, Brest
Target Recruit Count
3
Registration Number
NCT02839785
Locations
🇫🇷

Hôpital Morvan - CHRU Brest, Brest, France

🇫🇷

Hopitaux de Saint-Maurice, Saint-Maurice, France

🇫🇷

Ch Lannion-Trestel, Trevou-Treguignec, France

Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Low Back Pain Presented to the Emergency Department

Phase 4
Conditions
Interventions
First Posted Date
2016-07-19
Last Posted Date
2016-07-19
Lead Sponsor
Pamukkale University
Target Recruit Count
200
Registration Number
NCT02836509

Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation

First Posted Date
2016-06-21
Last Posted Date
2020-11-27
Lead Sponsor
Womack Army Medical Center
Target Recruit Count
300
Registration Number
NCT02807623
Locations
🇺🇸

Walter Reed National Military Medical Center, Bethesda, Maryland, United States

🇺🇸

Womack Army Medical Center, Fort Bragg, North Carolina, United States

Randomized Clinical Trial to Compare the Treatment of Mild Acute Diverticulitis With or Without Antibiotics

First Posted Date
2016-05-30
Last Posted Date
2020-05-14
Lead Sponsor
Corporacion Parc Tauli
Target Recruit Count
480
Registration Number
NCT02785549
Locations
🇪🇸

Corporació Sanitària Parc Taulí, Sabadell, Barcelona, Spain

Potential Efficacy and Safety of Using Adjunctive Ibuprofen for XDR-TB Tuberculosis

First Posted Date
2016-05-25
Last Posted Date
2019-12-17
Lead Sponsor
Fundació Institut Germans Trias i Pujol
Target Recruit Count
24
Registration Number
NCT02781909
Locations
🇬🇪

National Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia

🇿🇦

Perinatal HIV Unit (PHRU), Soweto, South Africa

Comparisons of iv Ibuprofen and iv Paracetamol During Bariatric Surgery

First Posted Date
2016-05-20
Last Posted Date
2018-03-14
Lead Sponsor
Inonu University
Target Recruit Count
40
Registration Number
NCT02778958
Locations
🇹🇷

Inonu University Faculty of Medicine Department of Anesthesiology and Reanimation, Malatya, Turkey

Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department

Phase 4
Conditions
Interventions
First Posted Date
2016-05-19
Last Posted Date
2016-07-15
Lead Sponsor
Pamukkale University
Target Recruit Count
120
Registration Number
NCT02777320
Locations
🇹🇷

Pamukkale University, Denizli, Turkey

Mechanism of Decreased Iron Absorption in Obesity: Controlling Adiposity-related Inflammation

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2016-04-20
Last Posted Date
2019-10-04
Lead Sponsor
Swiss Federal Institute of Technology
Target Recruit Count
40
Registration Number
NCT02745925
Locations
🇨🇭

Human Nutrition Laboratory ETH Zurich, Zurich, Switzerland

Delirium in Elderly Patients With Trauma of the Hip

First Posted Date
2016-02-23
Last Posted Date
2023-08-04
Lead Sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Target Recruit Count
239
Registration Number
NCT02689024
Locations
🇳🇱

Meander Medical Center, Amersfoort, Netherlands

🇳🇱

VU Medical Center, Amsterdam, Netherlands

🇳🇱

Academic Medical Center, Amsterdam, Netherlands

and more 2 locations
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