Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Incidence of TNS After Intrathecal Lidocaine v.s Bupivacaine

First Posted Date
2019-03-05
Last Posted Date
2019-03-05
Lead Sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Target Recruit Count
160
Registration Number
NCT03862287
Locations
🇨🇦

Montreal General Hospital, Montreal, Quebec, Canada

Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain

First Posted Date
2019-02-26
Last Posted Date
2024-05-01
Lead Sponsor
University of Kansas Medical Center
Target Recruit Count
75
Registration Number
NCT03854344
Locations
🇺🇸

The University of Kansas Health System, Kansas City, Kansas, United States

Lidocaine-Ketamine Versus Ketamine for Induction of Anesthesia in Septic Shock Patients

First Posted Date
2019-02-19
Last Posted Date
2019-11-26
Lead Sponsor
Cairo University
Target Recruit Count
43
Registration Number
NCT03844984
Locations
🇪🇬

Ahmed Mohamed Hasanin, Cairo, Egypt

Lidocaine Infusion in Hystroscopy

Phase 2
Completed
Conditions
Interventions
First Posted Date
2019-01-31
Last Posted Date
2020-01-28
Lead Sponsor
Ain Shams University
Target Recruit Count
44
Registration Number
NCT03825016
Locations
🇪🇬

Ain Shams University Maternity Hospital, Cairo, Egypt

Lidocaine and Perioperative Cytokine Levels in Blood and Cerebrospinal Fluid in Cerebral Aneurysm Patients

Not Applicable
Conditions
Interventions
First Posted Date
2019-01-30
Last Posted Date
2020-11-12
Lead Sponsor
Clinical Hospital Centre Zagreb
Target Recruit Count
40
Registration Number
NCT03823482
Locations
🇭🇷

UHCZagreb, Zagreb, Croatia

Is it Possible to Replace Fentanyl in Anesthesia for Minor Procedures?

First Posted Date
2019-01-16
Last Posted Date
2019-01-16
Lead Sponsor
Ain Shams University
Target Recruit Count
120
Registration Number
NCT03806374
Locations
🇪🇬

Ain Shams University hospitals, Cairo, Egypt

Intravenous Lidocaine to Supress of Cough Reflex During Anesthesia Emergence

Phase 3
Conditions
Interventions
First Posted Date
2019-01-15
Last Posted Date
2019-01-15
Lead Sponsor
Brasilia University Hospital
Target Recruit Count
132
Registration Number
NCT03805282
Locations
🇧🇷

Hospital Universitario de Brasilia, Brasília, Distrito Federal, Brazil

Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery

First Posted Date
2018-11-28
Last Posted Date
2024-10-14
Lead Sponsor
Göteborg University
Target Recruit Count
220
Registration Number
NCT03756961
Locations
🇸🇪

Lindesberg Hospital, Lindesberg, Region Örebro, Sweden

🇸🇪

Sahlgrenska University hospital/ Östra hopsital, Gothenburg, VG, Sweden

Bolus Administration of Intravenous Lidocaine at the Time of Abdominal Hysterectomy

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2018-11-20
Last Posted Date
2020-08-05
Lead Sponsor
Aswan University Hospital
Target Recruit Count
120
Registration Number
NCT03748108
Locations
🇪🇬

Aswan University, Aswan, Egypt

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