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Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Comparison of Effect on Quality of Recovery Outcome Between Systemic Lidocaine and Dexamethasone in Patients Undergoing Laparoscopic Cholecystectomy

Not Applicable
Terminated
Conditions
Gallbladder Polyp
Asymptomatic Gallstones Without Cholecystitis
Interventions
First Posted Date
2014-08-25
Last Posted Date
2019-03-19
Lead Sponsor
Yonsei University
Target Recruit Count
8
Registration Number
NCT02224170
Locations
๐Ÿ‡ฐ๐Ÿ‡ท

Department of Surgery, Yonsei University College of Medicine, Seoul, Korea, Seoul, Korea, Republic of

Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial

Phase 2
Completed
Conditions
Central Neuropathic Pain
Allodynia
Spinal Cord Injury
Interventions
Drug: Placebo (Dextromethorphan)
Drug: Lidocaine
Drug: Dextromethorphan
Drug: Placebo (Lidocaine)
First Posted Date
2014-08-18
Last Posted Date
2018-03-22
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
26
Registration Number
NCT02218203
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Translational Pain Research, Brigham and Women's Hospital, Boston, Massachusetts, United States

Long Term Outcome After Serial Lidocaine Infusion in Peripheral Neuropathic Pain

Phase 3
Completed
Conditions
Peripheral Neuropathy
Interventions
Drug: Placebo
Drug: Lidocaine
First Posted Date
2014-08-15
Last Posted Date
2022-11-30
Lead Sponsor
Mahidol University
Target Recruit Count
29
Registration Number
NCT02217267
Locations
๐Ÿ‡น๐Ÿ‡ญ

Faculty of medicine Siriraj Hospital Mahidol University, Bangkoknoi, Bangkok, Thailand

Lidocaine as Local Anesthetics in Children Under Ketamine Sedation

Phase 4
Conditions
Conscious Sedation Failure During Procedure
Analgesia
Anesthesia
Interventions
Drug: Normal saline
Drug: Lidocaine
First Posted Date
2014-07-31
Last Posted Date
2018-01-09
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
58
Registration Number
NCT02205502
Locations
๐Ÿ‡ฐ๐Ÿ‡ท

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of

Efficacy of Variable Lidocaine Concentrations in Tumescent Anesthesia for Pain Control During and After Endovenous Laser Procedure; Non-inferiority Trial

Not Applicable
Conditions
Pain During and After Endovenous Laser Obliteration of Large Saphenous Vein Based on Lidocaine Tumescent Concentration
Interventions
First Posted Date
2014-07-16
Last Posted Date
2014-07-16
Lead Sponsor
Midwest Vein Center
Target Recruit Count
70
Registration Number
NCT02192411
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Midwest Vein Center, Chicago, Illinois, United States

Effect of Perioperative Intravenous Lidocaine Infusion and Magnesium Infusion on the Functional Recovery After General Anesthesia in the Patients Undergoing Breast Mastectomy

Not Applicable
Completed
Conditions
Breast Cancer
Interventions
First Posted Date
2014-07-10
Last Posted Date
2015-10-19
Lead Sponsor
Yonsei University
Target Recruit Count
126
Registration Number
NCT02185859
Locations
๐Ÿ‡ฐ๐Ÿ‡ท

Yonsei University, College of Medicine, Yonsei Health System, Yonsei Cancer Center, Seoul, Korea, Republic of

Does Injection Site Matter? A Randomized Controlled Trial to Evaluate Efficacy of Knee Intraarticular Injections on Improval of Patient Reported Outcomes.

Phase 4
Completed
Conditions
Knee Osteoarthritis
Interventions
Drug: Depomedrol
Drug: Lidocaine
First Posted Date
2014-06-27
Last Posted Date
2017-06-01
Lead Sponsor
University of Puerto Rico
Target Recruit Count
60
Registration Number
NCT02176304
Locations
๐Ÿ‡ต๐Ÿ‡ท

University of Puerto Rico School Of Medicine Outpatient Clinics, San Juan, Puerto Rico

Comparison Study of Transversus Abdominal Plane, Paravertebral and Epidural Blocks in Laparoscopic Colectomy

Not Applicable
Terminated
Conditions
Laparoscopic Colorectal Resection
Interventions
First Posted Date
2014-06-17
Last Posted Date
2017-09-25
Lead Sponsor
Duke University
Target Recruit Count
17
Registration Number
NCT02164929
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Duke University Medical Center, Durham, North Carolina, United States

Endoscopic Ultrasound-guided Ethanol Injection of Pancreatic Cystic Neoplasms

Phase 1
Completed
Conditions
Neoplasms, Cystic, Mucinous, and Serous
Interventions
First Posted Date
2014-06-06
Last Posted Date
2018-02-05
Lead Sponsor
Mayo Clinic
Target Recruit Count
33
Registration Number
NCT02158039
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Mayo Clinic, Rochester, Minnesota, United States

Efficacy of Lidocaine Versus Placebo in Palliative Care Patients With Opioid-refractory Cancer Pain With Neuropathic Component: a Multicenter, Prospective, Double-blind Randomized Placebo-controlled Study.

Phase 3
Conditions
Cancer
Pain With Neuropathic Component
Interventions
Drug: Lidocaine
Drug: Placebo
First Posted Date
2014-05-14
Last Posted Date
2015-08-28
Lead Sponsor
Assistance Publique Hopitaux De Marseille
Target Recruit Count
200
Registration Number
NCT02137954
Locations
๐Ÿ‡ซ๐Ÿ‡ท

- Service d'Oncologie Mรฉdicale et de Soins Palliatifs Assistance Publique Hopitaux de Marseille, Marseille, France

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