Clarithromycin

Generic Name: Clarithromycin

Brand Names: Biaxin, Biaxin Bid, Omeclamox, Prevpac, Voquezna 14 Day Triplepak 20;500;500

Drug Type: Small Molecule

Chemical Formula: C_₃₈H_₆₉NO_₁₃

CAS Number: 81103-11-9

Unique Ingredient Identifier: H1250JIK0A

Background: Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bacteri...

Indication: An alternative medication for the treatment of acute otitis media caused by H. influenzae, M. catarrhalis, or S. pneumoniae in patients with a history of type I penicillin hypersensitivity. Also for the treatment of pharyngitis and tonsillitis caused by susceptible Streptococcus pyogenes, as well as respiratory tract infections including acute maxillary sinu...

Associated Conditions: Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB), Acute maxillary sinusitis, Bacterial Infections, Bartonellosis, Community Acquired Pneumonia (CAP), Duodenal ulcer caused by helicobacter pylori, Helicobacter Pylori Infection, Infective Endocarditis (IE), Lyme Disease, Mycobacterial Infections, Otitis Media (OM), Pertussis, Streptococcal Pharyngitis, Tonsillitis streptococcal, Uncomplicated skin and subcutaneous tissue bacterial infections

Associated Therapies: -

Clinical Trials

Effect of Vitamin D on Drug Resistant Helicobacter Pylori (HP) Eradication Study

Phase 3

Conditions: H. Pylori Infection

Interventions: Drug: Esomeprazole
Drug: Amoxicillin-Potassium Clavulanate Combination
Drug: Clarithromycin
Drug: Vitamin D3

First Posted Date: 2017-05-05

Last Posted Date: 2017-05-05

Lead Sponsor: Chinese University of Hong Kong

Target Recruit Count: 96

Registration Number: NCT03142620

Locations: 🇭🇰
Prince of Wales Hospital, Hong Kong, Hong Kong

Antimicrobial Susceptibility Testing Guided Triple Therapy in Salvage Helicobacter Pylori Treatment

Phase 4

Conditions: Antimicrobial Susceptibility Testing
Triple Therapy

Interventions: Drug: amoxicillin
Drug: tinidazole
Drug: clarithromycin
Drug: levofloxacin
Drug: furazolidone
Drug: tetracycline
Drug: Ilaprazole

First Posted Date: 2017-05-03

Last Posted Date: 2017-05-03

Lead Sponsor: Yanqing Li

Target Recruit Count: 120

Registration Number: NCT03139253

Intraluminal Therapy for Helicobacter Pylori Infection

Phase 4

Completed

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Lansoprazole
Drug: Amoxicillin
Drug: Clarithromycin

First Posted Date: 2017-04-21

Last Posted Date: 2018-05-02

Lead Sponsor: Mackay Memorial Hospital

Target Recruit Count: 100

Registration Number: NCT03124420

Locations: 🇨🇳
Division of Gastroenterology and Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan, Taipei, Taiwan

Cohorts of Docetaxel or Cabazitaxel in Combination With the Potent CYP3A4 Inhibitor, Clarithromycin

Phase 1

Terminated

Conditions: Prostate Cancer

Interventions: Drug: Docetaxel
Drug: Cabazitaxel
Drug: Clarithromycin

First Posted Date: 2017-02-06

Last Posted Date: 2020-02-17

Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Target Recruit Count: 4

Registration Number: NCT03043989

Locations: 🇺🇸
Johns Hopkins Hospital, Baltimore, Maryland, United States

Clarithromycin,Lenalidomide and Dexamethasone for Relapsed/Refractory Myeloma

Phase 2

Withdrawn

Conditions: Relapse/Refractory Multiple Myeloma

Interventions: Drug: clarithromycin
Drug: Lenalidomide
Drug: Dexamethasone

First Posted Date: 2016-12-08

Last Posted Date: 2018-08-14

Lead Sponsor: Sun Yat-sen University

Registration Number: NCT02986451

Locations: 🇨🇳
Sun Yat-sen University Cancer Center, GuangZhou, Guangdong, China

Evaluation of Metabolic Markers for the Prediction of DDI of Various CYP3A Substrates and Inhibitors

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Sildenafil
Drug: Clarithromycin
Drug: Itraconazole

First Posted Date: 2016-11-29

Last Posted Date: 2022-10-27

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 32

Registration Number: NCT02975037

Locations: 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of

Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis

Phase 2

Completed

Conditions: Aggressive Periodontitis

Interventions: Procedure: Full-mouth ultrasonic debridement
Drug: Amoxicillin
Drug: Clarithromycin
Drug: Metronidazole

First Posted Date: 2016-11-21

Last Posted Date: 2021-12-28

Lead Sponsor: Universidade Estadual Paulista Júlio de Mesquita Filho

Target Recruit Count: 46

Registration Number: NCT02969928

Locations: 🇧🇷
College of Dentistry - São José dos Campos, Sao Paulo State University, São José dos Campos, SP, Brazil

Tailored Versus Empiric Therapy for Helicobacter Pylori Treatment

Phase 4

Completed

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Esomeprazole
Drug: Bismuth Potassium Citrate
Drug: Amoxicillin
Drug: Metronidazole
Drug: Clarithromycin
Drug: Levofloxacin

First Posted Date: 2016-10-17

Last Posted Date: 2018-08-15

Lead Sponsor: Shanghai Jiao Tong University School of Medicine

Target Recruit Count: 382

Registration Number: NCT02935010

Locations: 🇨🇳
Shanghai General Hospital, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, Shanghai, China
🇨🇳
Zhongshan Hospital,Fudan University, Shanghai, Shanghai, China
🇨🇳
Shanghai Tenth People's Hospital, Tongji University, Shanghai, Shanghai, China

and more 2 locations