Magnesium sulfate
- Generic Name
- Magnesium sulfate
- Brand Names
- Concept Ob, Suflave, Suprep Bowel Prep Kit, Tis-U-sol
- Drug Type
- Small Molecule
- Chemical Formula
- MgO4S
- CAS Number
- 7487-88-9
- Unique Ingredient Identifier
- ML30MJ2U7I
- Background
A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
- Indication
Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.
- Associated Conditions
- Constipation, Convulsions, Hypomagnesemia, Torsades de Pointes, Barium poisoning, Severe Exacerbation of asthma
- Associated Therapies
- Bowel preparation therapy, Soaking aid for minor sprains and bruises
Effect of Magnesium Sulphate on Analgesia Following Knee Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2018-10-04
- Last Posted Date
- 2018-10-05
- Lead Sponsor
- Ufuk University
- Target Recruit Count
- 60
- Registration Number
- NCT03695640
- Locations
- 🇹🇷
Ufuk University Faculty of Medicine Hospital, Ankara, Balgat, Turkey
Intraperitoneal Dexamethasone vs Dexamethasone Plus Magnesium Sulphate for Pain Relief in Laparoscopic Cholecystectomy
- Conditions
- Interventions
- First Posted Date
- 2018-08-23
- Last Posted Date
- 2019-02-05
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 75
- Registration Number
- NCT03643666
- Locations
- 🇪🇬
Kasr Alaini hospital, Cairo, Egypt
Dexmedetomidine Versus Magnesium Sulfate Infusion During Spinal Anesthesia
- Conditions
- Interventions
- First Posted Date
- 2018-08-21
- Last Posted Date
- 2019-11-14
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 60
- Registration Number
- NCT03640390
- Locations
- 🇪🇬
Cairo University, Cairo, Egypt
Efficacy of Magnesium Sulfate on Reducing Renal Colic in the Emergency Department
- First Posted Date
- 2018-08-06
- Last Posted Date
- 2023-03-24
- Lead Sponsor
- Henry Ford Health System
- Target Recruit Count
- 37
- Registration Number
- NCT03617289
Thoracic Epidural Analgesia in Multiple Traumatic Fracture Ribs
- Conditions
- Interventions
- First Posted Date
- 2018-07-23
- Last Posted Date
- 2018-07-23
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 60
- Registration Number
- NCT03595397
Magnesium Sulphate Versus Lidocaine for Control of Emergence Hypertension
- Conditions
- Interventions
- First Posted Date
- 2018-06-25
- Last Posted Date
- 2019-08-15
- Lead Sponsor
- Ahmed Mohamed ELbadawy
- Target Recruit Count
- 90
- Registration Number
- NCT03566329
- Locations
- 🇪🇬
Ahmed ELbadawy, Cairo, Egypt
Magnesium Sulphate Versus Fentanyl for Conscious Sedation in CSDH
- Conditions
- Interventions
- First Posted Date
- 2018-06-07
- Last Posted Date
- 2018-12-04
- Lead Sponsor
- Kasr El Aini Hospital
- Target Recruit Count
- 34
- Registration Number
- NCT03548493
- Locations
- 🇪🇬
Kasr El Aini Hospital, Cairo, Egypt
Nifedipine Versus Magnesium Sulfate for Prevention of Preterm Labor in Symptomatic Placenta Previa
- First Posted Date
- 2018-05-31
- Last Posted Date
- 2021-07-28
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 176
- Registration Number
- NCT03542552
- Locations
- 🇪🇬
Assiut university, Assiut, Egypt
Interaction Between Magnesium and Neostigmine or Sugammadex for the Reversal of a Rocuronium-induced Neuromuscular Block
- First Posted Date
- 2018-04-13
- Last Posted Date
- 2023-04-18
- Lead Sponsor
- Christoph Czarnetzki
- Target Recruit Count
- 48
- Registration Number
- NCT03497923
- Locations
- 🇨🇭
Hôpital du Valais, Sion, Switzerland
🇨🇭University Hospital of Geneva, Anesthesia Department, Geneva, Canton Of Geneva, Switzerland
Detection of Epileptiform Activity in Severe Preeclampsia
- Conditions
- Interventions
- First Posted Date
- 2018-04-11
- Last Posted Date
- 2019-01-24
- Lead Sponsor
- Pascal Vuilleumier
- Target Recruit Count
- 35
- Registration Number
- NCT03494517
- Locations
- 🇨🇭
Bern University Hospital, Bern, Switzerland
Drug Development Updates
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