Magnesium sulfate
- Generic Name
- Magnesium sulfate
- Brand Names
- Concept Ob, Suflave, Suprep Bowel Prep Kit, Tis-U-sol
- Drug Type
- Small Molecule
- Chemical Formula
- MgO4S
- CAS Number
- 7487-88-9
- Unique Ingredient Identifier
- ML30MJ2U7I
- Background
A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
- Indication
Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.
- Associated Conditions
- Constipation, Convulsions, Hypomagnesemia, Torsades de Pointes, Barium poisoning, Severe Exacerbation of asthma
- Associated Therapies
- Bowel preparation therapy, Soaking aid for minor sprains and bruises
Magnesium Treating Subarachnoid Hemorrhage Vasospasm
- Conditions
- Cerebral VasospasmSubarachnoid Hemorrhage, Aneurysmal
- Interventions
- Drug: normal saline
- First Posted Date
- 2020-11-03
- Last Posted Date
- 2022-09-13
- Lead Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
- Target Recruit Count
- 200
- Registration Number
- NCT04613960
- Locations
- 🇪🇬
El matareya Educational Hospital, Cairo, Egypt
High Versus Low Dose of Magnesium Sulfate as Initial Tocolytic Agent for Preterm Labour in Symptomatic Placenta Previa.
- First Posted Date
- 2020-10-23
- Last Posted Date
- 2022-09-14
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 130
- Registration Number
- NCT04599868
- Locations
- 🇪🇬
Assiut University, Asyūţ, Egypt
Effect of Magnesium Sulphate Added to Mepivacaine Hydrochloride on Inferior Alveolar Nerve Block Success in Patients With Symptomatic Irreversible Pulpitis in Mandibular Molars: A Randomized Clinical Trial.
- Conditions
- Success of Inferior Alveolar Nerve Block
- Interventions
- Drug: Mepivacaine-Levonordefrin Hydrochloride
- First Posted Date
- 2020-09-24
- Last Posted Date
- 2020-09-29
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 56
- Registration Number
- NCT04561921
The Analgesic Efficacy of Magnesium and Ketorolac in Ultrasound Supraclavicular Block
- Conditions
- Postoperative Pain
- Interventions
- First Posted Date
- 2020-09-18
- Last Posted Date
- 2022-10-05
- Lead Sponsor
- Fayoum University Hospital
- Target Recruit Count
- 80
- Registration Number
- NCT04554862
- Locations
- 🇪🇬
Fayoum University hospital, Madīnat Al Fayyūm, Faiyum Governorate, Egypt
Evaluation of Intravenous Infusion of Labetalol Versus Magnesium Sulfate
- Conditions
- Magnesium SulfateLabetalol
- Interventions
- First Posted Date
- 2020-09-07
- Last Posted Date
- 2022-11-15
- Lead Sponsor
- Zagazig University
- Target Recruit Count
- 60
- Registration Number
- NCT04539379
- Locations
- 🇪🇬
Faculty of Medicine,Zagazig University, Zagazig, Zagazig, Elsharkia,egypt, Egypt
Opioid-free Analgesia for the Management of Acute Post-operative Pain Following Caesarean Section
- Conditions
- Acute Post-operative Pain Following Caesarean Section
- Interventions
- First Posted Date
- 2020-09-04
- Last Posted Date
- 2023-07-20
- Lead Sponsor
- Olakunle Ifeoluwa Makinde
- Target Recruit Count
- 324
- Registration Number
- NCT04539249
- Locations
- 🇳🇬
Federal Medical Centre, Yenagoa, Yenagoa, Bayelsa State, Nigeria
Magnesium Sulfate and Neuroendocrine Hormone
- Conditions
- Arthropathy of KneeCortisolMagnesium SulfateDehydroepiandrosterone
- Interventions
- Drug: Isotonic Saline
- First Posted Date
- 2020-08-17
- Last Posted Date
- 2021-09-24
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT04514731
- Locations
- 🇰🇷
Seoul National University Bundang Hospital, Seongnam-si, Korea, Republic of
Does Adding Magnesium Sulphate to Low Dose Rocuronium Affects Depth of Blockade
- Conditions
- Anesthesia
- Interventions
- First Posted Date
- 2020-08-12
- Last Posted Date
- 2021-03-05
- Lead Sponsor
- National Cancer Institute, Egypt
- Target Recruit Count
- 60
- Registration Number
- NCT04510337
- Locations
- 🇪🇬
National Cancer Institute, Cairo, Egypt
Magnesium Sulfate in Combination With Dexmedetomidine As Adjuvants to Levobupivacaine
- Conditions
- Spermatic Cord Block
- Interventions
- First Posted Date
- 2020-08-04
- Last Posted Date
- 2022-04-01
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 130
- Registration Number
- NCT04498351
- Locations
- 🇪🇬
Faculty of Medicine, Cairo University., Cairo, Egypt
Intravenous Magnesium in Patients Receiving Cisplatin
- First Posted Date
- 2020-07-22
- Last Posted Date
- 2022-01-11
- Lead Sponsor
- Dana-Farber Cancer Institute
- Target Recruit Count
- 5
- Registration Number
- NCT04481672
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Drug Development Updates
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