Remimazolam
- Generic Name
- Remimazolam
- Brand Names
- Byfavo
- Drug Type
- Small Molecule
- Chemical Formula
- C21H19BrN4O2
- CAS Number
- 308242-62-8
- Unique Ingredient Identifier
- 7V4A8U16MB
- Background
Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid biotransformation and elimination as inactive metabolites. These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/offset is desirable, enabling anesthesiologists to manipulate drug concentrations as needed. Remimazolam was the first "soft" benzodiazepine analog to be developed and was approved for use by the FDA in July 2020 under the brand name Byfavo.
- Indication
Remimazolam is indicated for the induction and maintenance of procedural sedation in adults undergoing procedures lasting 30 minutes or less.
- Associated Conditions
- Procedural Sedation
The 90% Effective Dose of Remimazolam for Duodenoscopy Insertion During ERCP With Alfentanil 10µg/kg
- First Posted Date
- 2021-09-22
- Last Posted Date
- 2021-12-20
- Lead Sponsor
- Jianbo Yu
- Target Recruit Count
- 120
- Registration Number
- NCT05053763
- Locations
- 🇨🇳
Tianjin Nankai Hospital, Tianjin, Tianjin, China
The Impact of Remimazolam for Postoperative Sedation on the Left Ventricular Systolic Performance in Cardiac Surgery
- First Posted Date
- 2021-09-13
- Last Posted Date
- 2021-09-13
- Lead Sponsor
- Konkuk University Medical Center
- Target Recruit Count
- 15
- Registration Number
- NCT05041725
Remimazolam and Remifentanil Without Neuromuscular Blocking Agent
- Conditions
- Myoma;UterusUnspecified Condition Associated With Female Genital Organs and Menstrual CyclePolyp Endometrium
- Interventions
- First Posted Date
- 2021-08-27
- Last Posted Date
- 2022-04-25
- Lead Sponsor
- Seoul National University Bundang Hospital
- Target Recruit Count
- 38
- Registration Number
- NCT05025410
- Locations
- 🇰🇷
Seoul National University Bundang Hospital, Seongnam, Korea, Republic of
Comparison of Postoperative QoR-15 Scores Between Sevoflurane and Remimazolam
- Conditions
- Anterior Cervical Discectomy and Fusion (ACDF) Surgery
- Interventions
- First Posted Date
- 2021-08-24
- Last Posted Date
- 2023-04-25
- Lead Sponsor
- Gangnam Severance Hospital
- Target Recruit Count
- 72
- Registration Number
- NCT05019222
- Locations
- 🇰🇷
Myung Hwa Kim, Seoul, Korea, Republic of
A Trial of Efficacy and Safety of Remimazolam Tosilate for Injection in Local Anesthesia Assisted Sedation
- Conditions
- Local Anesthesia Assisted Sedation
- Interventions
- First Posted Date
- 2021-08-20
- Last Posted Date
- 2021-08-20
- Lead Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
- Target Recruit Count
- 108
- Registration Number
- NCT05015361
- Locations
- 🇨🇳
West China Hospital, Chengdu, Sichuan, China
Comparison of Postoperative QoR-15 Scores Between Propofol and Remimazolam
- Conditions
- Patients Undergoing Spine Surgery
- Interventions
- Drug: Propfol group
- First Posted Date
- 2021-08-06
- Last Posted Date
- 2023-07-20
- Lead Sponsor
- Gangnam Severance Hospital
- Target Recruit Count
- 73
- Registration Number
- NCT04994704
- Locations
- 🇰🇷
GangnamSeverance Hospital, Seoul, Korea, Republic of
Comparison of Postoperative QoR-15 Scores Between Desflurane and Remimazolam in Lumbar Fusion Surgery
- First Posted Date
- 2021-07-30
- Last Posted Date
- 2024-04-30
- Lead Sponsor
- Gangnam Severance Hospital
- Target Recruit Count
- 76
- Registration Number
- NCT04983966
- Locations
- 🇰🇷
GangnamSeverance Hospital, Seoul, Korea, Republic of
The Median Effective Dose of Remimazolam for Duodenoscopy Insertion During ERCP With Alfentanil 10µg/kg
- First Posted Date
- 2021-07-20
- Last Posted Date
- 2022-01-10
- Lead Sponsor
- Tianjin Nankai Hospital
- Target Recruit Count
- 50
- Registration Number
- NCT04969068
- Locations
- 🇨🇳
Tianjin Nankai Hospital, Tianjin, Tianjin, China
Remimazolam and Endovascular Procedures of Cerebrovascular Diseases
- Conditions
- Cerebrovascular DisordersAnesthesia
- Interventions
- First Posted Date
- 2021-07-06
- Last Posted Date
- 2022-10-20
- Lead Sponsor
- Air Force Military Medical University, China
- Target Recruit Count
- 142
- Registration Number
- NCT04950621
- Locations
- 🇨🇳
Xijing hospital, Xi'an, Shaanxi, China
The Availability and Safety Study of Remimazolam Besylate for Injection on Sedation of ERAS Patients
- First Posted Date
- 2021-07-01
- Last Posted Date
- 2021-07-01
- Lead Sponsor
- Peking Union Medical College Hospital
- Target Recruit Count
- 84
- Registration Number
- NCT04947345
Drug Development Updates
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