Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998.
Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Celecoxib is indicated for symptomatic treatment of adult osteoarthritis (OA) and adult rheumatoid arthritis (RA). Celecoxib is not a substitute for aspirin for cardiovascular event prophylaxis.
It may be also be used to treat acute pain from various sources, juvenile rheumatoid arthritis in children over 2, ankylosing spondylitis, and primary dysmenorrhea.
Celecoxib, in combination with tramadol, is indicated for the management of acute pain in adults severe enough to require an opioid analgesic and in whom alternative treatments are inadequate.
Millard Fillmore Suburban Hospital, Williamsville, New York, United States
Cleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, United States
St. Joseph's Healthcare London, London, Ontario, Canada
King Abdulaziz University Hospital, Jeddah, Saudi Arabia
The University of Texas Health Science Center at Houston, Houston, Texas, United States
Roswell Park Cancer Institute, Buffalo, New York, United States
Roswell Park Cancer Institute, Buffalo, New York, United States
Providence - St. Jude Medical Center /ID# 242558, Fullerton, California, United States
Moores Cancer Center at UC San Diego /ID# 229584, La Jolla, California, United States
City of Hope /ID# 239769, Duarte, California, United States
University of Utah, Salt Lake City, Utah, United States
Endeavor Clinical Trials, LLC., San Antonio, Texas, United States
Helen Keller Hospital, Sheffield, Alabama, United States
Phoenix Clinical Research, LLC, Tamarac, Florida, United States
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