MedPath

Ephedrine

Generic Name
Ephedrine
Brand Names
Akovaz, Bronkaid, Corphedra, Emerphed, Primatene, Rezipres
Drug Type
Small Molecule
Chemical Formula
C10H15NO
CAS Number
299-42-3
Unique Ingredient Identifier
GN83C131XS
Background

Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles. Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects. Ephedrine and phenylephrine are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists. Ephedrine was granted a type 7 FDA Approval on 29 April 2016.

Indication

Ephedrine intravenous injections are indicated to treat hypotension under anesthesia, ephedrine injections by multiple routes are indicated to treat allergic conditions such as bronchial asthma, ephedrine nasal spray is and OTC medication used as a decongestant.

Associated Conditions
Allergic Reaction, Bronchial Asthma, Common Cold, Cough, Depression, Fever, General Anesthesia Induced Hypotension, Headache, Joint Pain, Myasthenia Gravis, Narcolepsy, Nasal Congestion, Rhinorrhoea, Sore Throat, Dry cough
Associated Therapies
-
Clinical Trials
Related News

Effects of Vasopressors on Cerebral Hemodynamics in Patients with Carotid Endarterectomy (TCD Part)

Not Applicable
Completed
Conditions
Carotid Endarterectomy
Interventions
Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine
First Posted Date
2022-12-27
Last Posted Date
2024-11-05
Lead Sponsor
Beijing Tiantan Hospital
Target Recruit Count
90
Registration Number
NCT05665881
Locations
🇨🇳

Beijing Tiantan Hospital, Capital Medical University, Beijing, China

HIgh Versus STAndard Blood Pressure Target in Hypertensive High-risk Patients Undergoing Major Abdominal Surgery

Not Applicable
Recruiting
Conditions
Complication,Postoperative
Intraoperative Hypotension
Blood Pressure
Interventions
Drug: Ephedrine
Drug: Norepinephrine
Drug: Etilefrine Hydrochloride bolus
Diagnostic Test: Use of pulse pressure and stroke volume variation (PPV and SVV); use of Mini Fluid Challenge (mini_FC)
First Posted Date
2022-12-05
Last Posted Date
2024-11-01
Lead Sponsor
Humanitas Clinical and Research Center
Target Recruit Count
636
Registration Number
NCT05637606
Locations
🇮🇹

Azienda Ospedaliero - Universitaria SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy

🇮🇹

Istituto Europeo di Oncologia (IEO), Milano, Italy

🇮🇹

Department of Anesthesia, Critical Care and Pain Medicine, SS. Annunziata Hospital, Chieti, Abruzzo, Italy

and more 15 locations

Comparative Efficacity of Ephedrine Versus Norepinephrine to Correct Anesthesia Induction Related Hypotension

Phase 3
Recruiting
Conditions
Hypotension on Induction
Interventions
Drug: Ephedrine
Drug: Norepinephrine
First Posted Date
2022-08-11
Last Posted Date
2022-09-16
Lead Sponsor
Brugmann University Hospital
Target Recruit Count
60
Registration Number
NCT05497700
Locations
🇧🇪

CHU Brugmann, Brussels, Belgium

Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (MRI Part)

Not Applicable
Not yet recruiting
Conditions
Carotid Endarterectomy
Interventions
Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine
First Posted Date
2022-06-10
Last Posted Date
2023-08-24
Lead Sponsor
Beijing Tiantan Hospital
Target Recruit Count
60
Registration Number
NCT05414877

Evaluation of the Early Use of Norepinephrine in Major Abdominal Surgery on Postoperative Organ Dysfunction

Not Applicable
Recruiting
Conditions
Norepinephrine
Hypotension
Major Abdominal Surgery
Anesthesiology
Interventions
Drug: Norepinephrine
Drug: Ephedrine
First Posted Date
2022-03-11
Last Posted Date
2023-03-22
Lead Sponsor
Centre Hospitalier Universitaire, Amiens
Target Recruit Count
500
Registration Number
NCT05276596
Locations
🇫🇷

CHU Amiens, Amiens, France

Biphasic Effects of Different Doses Ephedrine on Hemodynamics in Elderly Patients Under General Anesthesia

Not Applicable
Conditions
Blood Pressure
Interventions
Drug: Ephedrine
First Posted Date
2021-06-22
Last Posted Date
2021-07-22
Lead Sponsor
Yangzhou University
Target Recruit Count
70
Registration Number
NCT04934852
Locations
🇨🇳

the Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China

Effects of Ephedrine, Phenylephrine, Norepinephrine and Vasopressin on Contractility of Human Myometrium and Umbilical Vessels: An In-vitro Study

Not Applicable
Recruiting
Conditions
Hypotension
Interventions
Drug: Vasopressin
Drug: Norepinephrine
Drug: Ephedrine
Drug: Phenylephrine
First Posted Date
2019-08-12
Last Posted Date
2024-03-07
Lead Sponsor
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Target Recruit Count
144
Registration Number
NCT04053478
Locations
🇨🇦

Mount Sinai Hospital, Toronto, Ontario, Canada

Closed-loop Double-vasopressor Automated System to Treat Hypotension During Spinal Anaesthesia for Caesarean Section

Phase 2
Completed
Conditions
Hypotension
Interventions
Drug: Phenylephrine
Device: Vasopressor automated delivery system
Device: Manual vasopressor delivery system
Drug: Ephedrine
First Posted Date
2019-07-19
Last Posted Date
2019-07-19
Lead Sponsor
KK Women's and Children's Hospital
Target Recruit Count
216
Registration Number
NCT04025918

Hemodynamics During Induction of General Anesthesia After Prophylactic Ephedrine, Phenylephrine or Norepinephrine.

Phase 4
Completed
Conditions
Anesthesia, General
Anesthesia, Intravenous
Hemodynamic Instability
Interventions
Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine
Drug: Sodium chloride
Drug: Propofol
Drug: Remifentanil
First Posted Date
2019-03-06
Last Posted Date
2024-10-04
Lead Sponsor
Helse Fonna
Target Recruit Count
128
Registration Number
NCT03864094
Locations
🇳🇴

Helse Fonna, Haugesund Sykehus, Haugesund, Norway

Comparison of Phenylephrine and Ephedrine in the Treatment of Hemodynamic Disorders After Spinal Anesthesia in the Elderly

Not Applicable
Completed
Conditions
Hip Fractures
Elderly Patients
Spinal Anesthesia
Lower Limb Surgery
Interventions
Drug: Phenylephrine
Drug: Ephedrine
First Posted Date
2019-02-28
Last Posted Date
2023-02-24
Lead Sponsor
Medical University of Warsaw
Target Recruit Count
50
Registration Number
NCT03858465
Locations
🇵🇱

Infant Jesus Teaching Hospital, Warsaw, Poland

© Copyright 2025. All Rights Reserved by MedPath
HomeTerms & ConditionsPrivacy Policy