Ephedrine

Generic Name: Ephedrine

Brand Names: Akovaz, Bronkaid, Corphedra, Emerphed, Primatene, Rezipres

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₅NO

CAS Number: 299-42-3

Unique Ingredient Identifier: GN83C131XS

Background: Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles. Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects. Ephedrine and phenylephrine are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists. Ephedrine was granted a type 7 FDA Approval on 29 April 2016.

Indication: Ephedrine intravenous injections are indicated to treat hypotension under anesthesia, ephedrine injections by multiple routes are indicated to treat allergic conditions such as bronchial asthma, ephedrine nasal spray is and OTC medication used as a decongestant.

Associated Conditions: Allergic Reaction, Bronchial Asthma, Common Cold, Cough, Depression, Fever, General Anesthesia Induced Hypotension, Headache, Joint Pain, Myasthenia Gravis, Narcolepsy, Nasal Congestion, Rhinorrhoea, Sore Throat, Dry cough

Clinical Trials

Could Ephedrine Replace Dexmedetomidine Fordexmedetomidine Prevention of Shivering in Women Undergoing Cesarean Section Under Spinal Anaesthesia

Not Applicable

Recruiting

Conditions: Prevention of Shivering With Spinal Anaesthesia

Interventions: Drug: Ephedrine
Drug: Dexmedetomidine

First Posted Date: 2024-01-31

Last Posted Date: 2024-01-31

Lead Sponsor: Assiut University

Target Recruit Count: 200

Registration Number: NCT06233032

Locations: 🇪🇬
Assiut university, Assiut, Egypt

Comparative Study Among Different Doses of Ephedrine During Elective Cesarean Section Under Subarachnoid Block.

Phase 4

Completed

Conditions: Anesthesia
Cesarean Section Complications
Subarachnoid Block

Interventions: Drug: Ephedrine 5mg
Drug: Ephedrine 15mg
Drug: Ephedrine 10mg

First Posted Date: 2023-08-15

Last Posted Date: 2024-03-01

Lead Sponsor: Aswan University

Target Recruit Count: 300

Registration Number: NCT05993182

Locations: 🇪🇬
Aswan University, Aswan, Egypt

Cerebral Flow-metabolism Coupling During Adult Surgery

Phase 4

Recruiting

Conditions: Anesthesia

Interventions: Drug: Propofol
Drug: Sevoflurane
Drug: Phenylephrine
Drug: Ephedrine

First Posted Date: 2023-07-12

Last Posted Date: 2023-10-18

Lead Sponsor: Jason Chui

Target Recruit Count: 80

Registration Number: NCT05941494

Locations: 🇨🇦
London Health Sciences Centre, London, Ontario, Canada

The Effect of Low-dose Atropine on Sympathetic Blockade in Spinal Cesarean Section Patients

Phase 4

Completed

Conditions: Anesthesia, Spinal
Pregnancy
Cesarean Section

Interventions: Drug: Slow dose preemptive Atropine
Drug: Ephedrine

First Posted Date: 2023-06-07

Last Posted Date: 2023-10-11

Lead Sponsor: Abant Izzet Baysal University

Target Recruit Count: 60

Registration Number: NCT05892913

Locations: 🇹🇷
Bolu Abant Izzet Baysal university Medical School, Anesthesiology and Reanimation D., Bolu, Turkey

Impact of Prophylactic Ephedrine on Fetal Heart Tracing and Uterine Tetanic Contraction After CSE

Phase 4

Recruiting

Conditions: Labor

Interventions: Drug: Normal Saline Placebo
Drug: Ephedrine

First Posted Date: 2023-05-24

Last Posted Date: 2025-05-07

Lead Sponsor: Icahn School of Medicine at Mount Sinai

Target Recruit Count: 135

Registration Number: NCT05873218

Locations: 🇺🇸
Icahn School of Medicine at Mount SInai, New york, New York, United States

Intubation Conditions After RSI Using Rocuronium with Ephedrine Pretreatment

Phase 3

Completed

Conditions: Rapid Sequence Induction and Intubation

Interventions: Drug: Rocuronium 1.2
Drug: Ephedrine
Drug: Rocuronium 0.8
Drug: Rocuronium 0.6

First Posted Date: 2023-02-13

Last Posted Date: 2024-10-14

Lead Sponsor: Ain Shams University

Target Recruit Count: 75

Registration Number: NCT05725031

Locations: 🇪🇬
Ain Shams University Hospitals, Cairo, Egypt

Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (TCD Part)

Not Applicable

Completed

Conditions: Carotid Endarterectomy

Interventions: Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2022-12-27

Last Posted Date: 2025-02-28

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 90

Registration Number: NCT05665881

Locations: 🇨🇳
Beijing Tiantan Hospital, Capital Medical University, Beijing, China

HIgh Versus STAndard Blood Pressure Target in Hypertensive High-risk Patients Undergoing Major Abdominal Surgery

Not Applicable

Recruiting

Conditions: Complication,Postoperative
Intraoperative Hypotension
Blood Pressure

Interventions: Drug: Ephedrine
Drug: Norepinephrine
Drug: Etilefrine Hydrochloride bolus
Diagnostic Test: Use of pulse pressure and stroke volume variation (PPV and SVV); use of Mini Fluid Challenge (mini_FC)

First Posted Date: 2022-12-05

Last Posted Date: 2025-02-19

Lead Sponsor: Humanitas Clinical and Research Center

Target Recruit Count: 636

Registration Number: NCT05637606

Locations: 🇮🇹
Azienda Ospedaliero - Universitaria SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
🇮🇹
Istituto Europeo di Oncologia (IEO), Milano, Italy
🇮🇹
Department of Anesthesia, Critical Care and Pain Medicine, SS. Annunziata Hospital, Chieti, Abruzzo, Italy

and more 15 locations