Ephedrine

Generic Name: Ephedrine

Brand Names: Akovaz, Bronkaid, Corphedra, Emerphed, Primatene, Rezipres

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₅NO

CAS Number: 299-42-3

Unique Ingredient Identifier: GN83C131XS

Background: Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles. Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects. Ephedrine and phenylephrine are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists. Ephedrine was granted a type 7 FDA Approval on 29 April 2016.

Indication: Ephedrine intravenous injections are indicated to treat hypotension under anesthesia, ephedrine injections by multiple routes are indicated to treat allergic conditions such as bronchial asthma, ephedrine nasal spray is and OTC medication used as a decongestant.

Associated Conditions: Allergic Reaction, Bronchial Asthma, Common Cold, Cough, Depression, Fever, General Anesthesia Induced Hypotension, Headache, Joint Pain, Myasthenia Gravis, Narcolepsy, Nasal Congestion, Rhinorrhoea, Sore Throat, Dry cough

Clinical Trials

Comparison of Phenylephrine and Ephedrine in the Treatment of Hemodynamic Disorders After Spinal Anesthesia in the Elderly

Not Applicable

Completed

Conditions: Hip Fractures
Elderly Patients
Spinal Anesthesia
Lower Limb Surgery

Interventions: Drug: Phenylephrine
Drug: Ephedrine

First Posted Date: 2019-02-28

Last Posted Date: 2023-02-24

Lead Sponsor: Medical University of Warsaw

Target Recruit Count: 50

Registration Number: NCT03858465

Locations: 🇵🇱
Infant Jesus Teaching Hospital, Warsaw, Poland

Influence of a Bolus Administration of Ephedrine and Phenylephrine on the Spinal Oxygen Saturation, Measured With NIRS.

Phase 4

Completed

Conditions: Influence of Vasoactive Medication on Spinal Oxygenation

Interventions: Drug: Ephedrine Hydrochloride 3 MG/ML
Drug: Phenylephrine

First Posted Date: 2018-12-06

Last Posted Date: 2018-12-07

Lead Sponsor: University Hospital, Ghent

Target Recruit Count: 33

Registration Number: NCT03767296

Locations: 🇧🇪
University Hospital Ghent, Gent, Oost-Vlaanderen, Belgium

Norepinephrine Versus Ephedrin for Prevention of Post Spinal Anesthesia in Cesarean Section

Phase 4

Conditions: Cesarean
Maternal Hypotension Syndrome

Interventions: Drug: Norepinephrine
Drug: Ephedrine

First Posted Date: 2018-10-25

Last Posted Date: 2018-12-03

Lead Sponsor: Mongi Slim Hospital

Target Recruit Count: 200

Registration Number: NCT03719625

Manging Post Spinal Hypotension During Elective Cesarean Section

Phase 4

Completed

Conditions: Hypotension

Interventions: Drug: Adrenaline
Drug: Ephedrine

First Posted Date: 2018-10-15

Last Posted Date: 2019-03-13

Lead Sponsor: Ben marzouk Sofiene

Target Recruit Count: 143

Registration Number: NCT03704909

Locations: 🇹🇳
Tunis maternity and neonatology center,, Tunis, Tunisia

Development of Advanced Double Intravenous Vasopressor Automated (ADIVA) System

Not Applicable

Active, not recruiting

Conditions: Anesthesia
Hypotension

Interventions: Drug: Phenylephrine
Drug: Ephedrine
Device: ADIVA System
Device: DIVA System

First Posted Date: 2018-08-08

Last Posted Date: 2024-10-09

Lead Sponsor: KK Women's and Children's Hospital

Target Recruit Count: 173

Registration Number: NCT03620942

Locations: 🇸🇬
KK Women's and Children's Hospital, Singapore, Singapore

Combined Colloids And Crystalloids Versus Crystalloids in Women With Preeclampsia Undergoing Cesarean Delivery

Not Applicable

Completed

Conditions: Pre-Eclampsia
Cesarean Section

Interventions: Procedure: Spinal Anesthesia
Drug: Intrathecal Bupivacaine
Drug: Intrathecal Fentanyl
Procedure: Cesarean Delivery
Radiation: Ultrasound Assessment of the Inferior Vena Cava
Drug: 250 mL Colloid over 5 minutes
Drug: 250 mL Crystalloid over 5 minutes
Drug: 500 mL Crystalloid over 55 minutes
Drug: 250 mL Colloid over 60 minutes
Drug: 250 mL Crystalloid over 60 minutes
Drug: Intravenous Ephedrine
Drug: Intravenous Syntocinon

First Posted Date: 2017-08-17

Last Posted Date: 2021-09-05

Lead Sponsor: Mansoura University

Target Recruit Count: 140

Registration Number: NCT03252496

Locations: 🇪🇬
Department of Anesthesia, Mansoura University Hospitals, Mansoura, Dakahlia, Egypt

Norepinephrine Versus Ephedrine in Treatment of Hypotension During Spinal Anesthesia for Caesarean Section

Not Applicable

Completed

Conditions: Cesarean Section Complications
Hypotension
Anesthesia Complication
Vasopressors

Interventions: Drug: Ephedrine
Drug: Norepinephrine

First Posted Date: 2017-05-23

Last Posted Date: 2017-05-23

Lead Sponsor: Mongi Slim Hospital

Target Recruit Count: 110

Registration Number: NCT03163407

Ephedrine and Phenylephrine for Spinal Hypotension

Phase 2

Completed

Conditions: Spinal Hypotension

Interventions: Drug: Ephedrine
Drug: Phenylephrine

First Posted Date: 2017-02-08

Last Posted Date: 2020-10-27

Lead Sponsor: Assiut University

Target Recruit Count: 60

Registration Number: NCT03047109

Locations: 🇪🇬
Assiut university hospital, Assiut, Egypt

Combined Colloid Preload And Crystalloid Coload Versus Crystalloid Coload During Spinal Anesthesia for Cesarean Delivery

Not Applicable

Completed

Conditions: Anesthesia, Spinal
Cesarean Section

Interventions: Drug: 500 mL Colloid Preload
Drug: Intrathecal Bupivacaine
Procedure: Spinal Anesthesia
Drug: Intrathecal Fentanyl
Drug: 1000 mL Crystalloid Coload
Drug: 500 mL Crystalloid Coload
Procedure: Cesarean Delivery
Drug: Intravenous Ephedrine
Radiation: Ultrasound Assessment of the Inferior Vena Cava