Ephedrine

Generic Name: Ephedrine

Brand Names: Akovaz, Bronkaid, Corphedra, Emerphed, Primatene, Rezipres

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₅NO

CAS Number: 299-42-3

Unique Ingredient Identifier: GN83C131XS

Background: Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles. Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects. Ephedrine and phenylephrine are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists. Ephedrine was granted a type 7 FDA Approval on 29 April 2016.

Indication: Ephedrine intravenous injections are indicated to treat hypotension under anesthesia, ephedrine injections by multiple routes are indicated to treat allergic conditions such as bronchial asthma, ephedrine nasal spray is and OTC medication used as a decongestant.

Associated Conditions: Allergic Reaction, Bronchial Asthma, Common Cold, Cough, Depression, Fever, General Anesthesia Induced Hypotension, Headache, Joint Pain, Myasthenia Gravis, Narcolepsy, Nasal Congestion, Rhinorrhoea, Sore Throat, Dry cough

Clinical Trials

Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (MRI Part)

Not Applicable

Not yet recruiting

Conditions: Carotid Endarterectomy

Interventions: Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2022-06-10

Last Posted Date: 2023-08-24

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 60

Registration Number: NCT05414877

Evaluation of the Early Use of Norepinephrine in Major Abdominal Surgery on Postoperative Organ Dysfunction

Not Applicable

Recruiting

Conditions: Norepinephrine
Hypotension
Major Abdominal Surgery
Anesthesiology

Interventions: Drug: Norepinephrine
Drug: Ephedrine

First Posted Date: 2022-03-11

Last Posted Date: 2023-03-22

Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Target Recruit Count: 500

Registration Number: NCT05276596

Locations: 🇫🇷
CHU Amiens, Amiens, France

Changes in Cardiac Output During Cesarean Delivery Under Spinal Anesthesia

Completed

Conditions: Cardiac Output
Cesarean Section
Anesthesia, Spinal
Echocardiography

Interventions: Radiation: Transthoracic Echocardiography
Procedure: Spinal Anesthesia
Drug: Intrathecal Bupivacaine
Drug: Intrathecal Fentanyl
Drug: Crystalloid Coload 1000 mL
Procedure: Cesarean Delivery
Drug: Intravenous Ephedrine
Drug: Oxytocin

First Posted Date: 2022-03-08

Last Posted Date: 2022-11-29

Lead Sponsor: Mansoura University

Target Recruit Count: 60

Registration Number: NCT05269537

Locations: 🇪🇬
Department of Anesthesia and Surgical Critical Care, Mansoura University Hospitals, Mansoura, Dakahlia, Egypt

Ephedrine Versus Ondansetron During Cesarean Delivery

Phase 4

Completed

Conditions: Spinal Induced Hypotension

Interventions: Drug: Ondansetron 4 MG
Drug: EPHEDrine 10 Mg/mL-NaCl 0.9% Intravenous Solution
Other: 10 mL normal saline
Drug: Ondansetron 8mg

First Posted Date: 2021-11-19

Last Posted Date: 2022-09-09

Lead Sponsor: Ain Shams University

Target Recruit Count: 168

Registration Number: NCT05127876

Locations: 🇪🇬
Ain Shams University Hospitals, Cairo, Egypt

Biphasic Effects of Different Doses Ephedrine on Hemodynamics in Elderly Patients Under General Anesthesia

Not Applicable

Conditions: Blood Pressure

Interventions: Drug: Ephedrine

First Posted Date: 2021-06-22

Last Posted Date: 2021-07-22

Lead Sponsor: Yangzhou University

Target Recruit Count: 70

Registration Number: NCT04934852

Locations: 🇨🇳
the Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China

Ultrasonography for Fluid Assessment in Parturients With Preeclampsia Undergoing Cesarean Section

Completed

Conditions: Elective Cesarean Section
Preeclampsia

Interventions: Procedure: Spinal Anesthesia
Drug: Intrathecal Bupivacaine
Drug: Intrathecal Fentanyl
Procedure: Cesarean Delivery
Radiation: lung ultrasound scans
Other: Ultrasound Assessment of the Inferior Vena Cava
Other: Optic nerve sheath diameter
Drug: ringer acetate
Drug: Intravenous Ephedrine
Drug: Intravenous Syntocinon