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Ephedrine

Generic Name
Ephedrine
Brand Names
Akovaz, Bronkaid, Corphedra, Emerphed, Primatene, Rezipres
Drug Type
Small Molecule
Chemical Formula
C10H15NO
CAS Number
299-42-3
Unique Ingredient Identifier
GN83C131XS
Background

Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles. Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects. Ephedrine and phenylephrine are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists. Ephedrine was granted a type 7 FDA Approval on 29 April 2016.

Indication

Ephedrine intravenous injections are indicated to treat hypotension under anesthesia, ephedrine injections by multiple routes are indicated to treat allergic conditions such as bronchial asthma, ephedrine nasal spray is and OTC medication used as a decongestant.

Associated Conditions
Allergic Reaction, Bronchial Asthma, Common Cold, Cough, Depression, Fever, General Anesthesia Induced Hypotension, Headache, Joint Pain, Myasthenia Gravis, Narcolepsy, Nasal Congestion, Rhinorrhoea, Sore Throat, Dry cough
Associated Therapies
-
Clinical Trials
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Conditions
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Interventions
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First Posted Date
2018-10-25
Last Posted Date
2018-12-03
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Registration Number
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Manging Post Spinal Hypotension During Elective Cesarean Section

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Registration Number
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Development of Advanced Double Intravenous Vasopressor Automated (ADIVA) System

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First Posted Date
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Norepinephrine Versus Ephedrine in Treatment of Hypotension During Spinal Anesthesia for Caesarean Section

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First Posted Date
2017-05-23
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2017-05-23
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Ephedrine and Phenylephrine for Spinal Hypotension

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First Posted Date
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Last Posted Date
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Registration Number
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2016-10-31
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Registration Number
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