DeepMed Research

Ephedrine

Generic Name: Ephedrine

Brand Names: Akovaz, Bronkaid, Corphedra, Emerphed, Primatene, Rezipres

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₅NO

CAS Number: 299-42-3

Unique Ingredient Identifier: GN83C131XS

Background: Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles. Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects. Ephedrine and phenylephrine are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists. Ephedrine was granted a type 7 FDA Approval on 29 April 2016.

Indication: Ephedrine intravenous injections are indicated to treat hypotension under anesthesia, ephedrine injections by multiple routes are indicated to treat allergic conditions such as bronchial asthma, ephedrine nasal spray is and OTC medication used as a decongestant.

Associated Conditions: Allergic Reaction, Bronchial Asthma, Common Cold, Cough, Depression, Fever, General Anesthesia Induced Hypotension, Headache, Joint Pain, Myasthenia Gravis, Narcolepsy, Nasal Congestion, Rhinorrhoea, Sore Throat, Dry cough

Clinical Trials

Cafedrin/Theodrenalin (Akrinor®) Versus Ephedrine for Treatment of Hypotension in the Peri-operative Phase in Inpatient Setting

Completed

Conditions: Hypotension

Interventions: Drug: Cafedrine/theodrenaline
Drug: Ephedrine

First Posted Date: 2016-09-08

Last Posted Date: 2021-11-09

Lead Sponsor: Ratiopharm GmbH

Target Recruit Count: 2013

Registration Number: NCT02893241

Locations: 🇩🇪
Teva Investigational Site 122, Amberg, Germany
🇩🇪
Teva Investigational Site 106, Aue, Germany
🇩🇪
Teva Investigational Site 133, Aachen, Germany

and more 71 locations

Decision Support for Intraoperative Low Blood Pressure

Not Applicable

Completed

Conditions: Hypotension

Interventions: Procedure: Attending real-time decision support
Procedure: In-room real-time decision support
Procedure: Attending feedback emails
Procedure: In-room provider feedback emails
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Device: Pager system
Procedure: Central neuraxial anesthesia
Procedure: Non-cardiac surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Desflurane
Drug: Isoflurane
Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine
Drug: Epinephrine
Drug: Dobutamine
Drug: Sodium Chloride 0.9%
Drug: Dopamine
Drug: Isoproterenol
Drug: Milrinone
Drug: Fresh Frozen Plasma
Drug: Atropine
Drug: Glycopyrrolate
Drug: Vasopressin
Drug: Terlipressin
Drug: Ringer's lactate
Drug: Hydroxyethyl starch solutions
Drug: Packed Red Blood Cells
Drug: Albumin solutions
Drug: Plasma-Lyte
Drug: Lidocaine
Drug: Bupivacaine
Drug: Levobupivacaine
Drug: Ropivacaine
Drug: Mepivacaine
Drug: Tetracaine
Drug: Prilocaine
Drug: Procaine
Drug: Chloroprocaine
Drug: Benzocaine
Drug: Articaine

First Posted Date: 2016-04-04

Last Posted Date: 2019-05-16

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 22435

Registration Number: NCT02726620

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

Vasopressor Effects in Anesthetized Patients

Phase 4

Completed

Conditions: Brain Tumor

Interventions: Drug: Ephedrine
Drug: Phenylephrine

First Posted Date: 2016-03-18

Last Posted Date: 2018-10-26

Lead Sponsor: University of Aarhus

Target Recruit Count: 48

Registration Number: NCT02713087

Locations: 🇩🇰
Aarhus University Hospital, Aarhus, Jylland, Denmark

Effects of Systemic or Adjunct Tramadol Addition to Lidocaine Used for IVRA in Patients Undergoing Hand Surgery

Phase 3

Completed

Conditions: Anesthesia

Interventions: Drug: lidocaine+adjunct tramadol
Drug: lidocaine+systemic tramadol
Drug: Lidocaine
Drug: Fentanyl
Drug: Atropine
Drug: Midazolam
Drug: Diclofenac sodium
Drug: Ephedrine
Drug: Ondansetron

First Posted Date: 2016-01-20

Last Posted Date: 2016-01-20

Lead Sponsor: Bagcilar Training and Research Hospital

Target Recruit Count: 60

Registration Number: NCT02658721

Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia

Phase 2

Completed

Conditions: Coagulation Defect; Bleeding

Interventions: Drug: hydroxyethyl starch (6% 130/0.4)
Drug: Hyperbaric bupivacaine
Drug: Morphine
Drug: Isotonic 0.9 sodium chloride (NaCl) solution
Drug: Ephedrine
Drug: Atropine

First Posted Date: 2015-12-04

Last Posted Date: 2016-11-08

Lead Sponsor: Assiut University

Target Recruit Count: 60

Registration Number: NCT02622126

Locations: 🇪🇬
Faculty of Medicine, Assiut, Egypt

Comparison of Norepinephrine and Ephedrine on Hypotension After Spinal Anesthesia in Parturients

Not Applicable

Completed

Conditions: Hypotension
Obstetrical Complication of Anesthesia
Complications; Cesarean Section

Interventions: Drug: Norepinephrine
Drug: Ephedrine

First Posted Date: 2015-09-07

Last Posted Date: 2019-01-15

Lead Sponsor: Air Force Military Medical University, China

Target Recruit Count: 66

Registration Number: NCT02542748

Locations: 🇨🇳
Xijing Hospital,Fourth Military Medical University, Xi'an, Shaanxi, China

Anticholinergic Premedication for Sedation With Dexmedetomidine During Spinal Anesthesia

Phase 4

Completed

Conditions: Bradycardia

Interventions: Drug: Atropine
Drug: Dexmedetomidine
Drug: Ephedrine

First Posted Date: 2015-08-13

Last Posted Date: 2016-01-18

Lead Sponsor: Sira Bang

Target Recruit Count: 120

Registration Number: NCT02522858

Locations: 🇰🇷
Inje University Seoul Paik Hospital, Seoul, Korea, Seoul, Jung-Gu,, Korea, Republic of

Ephedrine vs. Nor Epinephrine Infusion in Preventing Hypotension After Spinal Anesthesia for Cesarean Section

Phase 4

Completed

Conditions: Hypotension
Complications; Cesarean Section
Anesthesia; Adverse Effect, Spinal and Epidural

Interventions: Drug: Ephedrine
Drug: Norepinephrine

First Posted Date: 2015-06-22

Last Posted Date: 2017-10-26

Lead Sponsor: University Tunis El Manar

Target Recruit Count: 120

Registration Number: NCT02477501

Locations: 🇹🇳
Tunis maternity and neonatology center, minisetry of public health, Tunis, Tunisia

Comparison of Remifentanil and Dexmedetomidine for Monitored Anaesthesia Care During Vertebroplasty and Kyphoplasty

Not Applicable

Completed

Conditions: Fractures, Compression

Interventions: Drug: Remifentanil
Drug: Dexmedetomidine
Drug: midazolam
Drug: propofol
Drug: ephedrine

First Posted Date: 2015-06-22

Last Posted Date: 2015-06-24

Lead Sponsor: Hallym University Medical Center

Target Recruit Count: 75

Registration Number: NCT02476981

Locations: 🇰🇷
Hallym University Sacred Heart Hospital, Anyang-si, Dongan-gu, Korea, Republic of

Nefopam vs Tramadol in the Prevention of Post Anaesthetic Shivering

Phase 2

Conditions: Post Anaesthetic Shivering

Interventions: Drug: Tramadol
Drug: Nefopam
Drug: Metoclopramide
Drug: Ranitidine
Drug: Pethidine
Drug: Ephedrine
Drug: oxytocin

First Posted Date: 2015-05-12

Last Posted Date: 2018-07-17

Lead Sponsor: Lagos State Health Service Commission

Target Recruit Count: 130

Registration Number: NCT02441673

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