Ephedrine

Generic Name: Ephedrine

Brand Names: Akovaz, Bronkaid, Corphedra, Emerphed, Primatene, Rezipres

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₅NO

CAS Number: 299-42-3

Unique Ingredient Identifier: GN83C131XS

Background: Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles. Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects. Ephedrine and phenylephrine are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists. Ephedrine was granted a type 7 FDA Approval on 29 April 2016.

Indication: Ephedrine intravenous injections are indicated to treat hypotension under anesthesia, ephedrine injections by multiple routes are indicated to treat allergic conditions such as bronchial asthma, ephedrine nasal spray is and OTC medication used as a decongestant.

Associated Conditions: Allergic Reaction, Bronchial Asthma, Common Cold, Cough, Depression, Fever, General Anesthesia Induced Hypotension, Headache, Joint Pain, Myasthenia Gravis, Narcolepsy, Nasal Congestion, Rhinorrhoea, Sore Throat, Dry cough

Clinical Trials

Phenylephrine Versus Ephedrine in Pre-eclampsia

Phase 4

Terminated

Conditions: Pre-eclampsia

Interventions: Drug: Ephedrine
Drug: Phenylephrine

First Posted Date: 2014-01-01

Last Posted Date: 2020-10-14

Lead Sponsor: Duke University

Target Recruit Count: 13

Registration Number: NCT02025426

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

Intrathecal Levobupivacaine With Opioids for Caesarean Section

Phase 3

Completed

Conditions: Elective Caesarean Section Surgeries

Interventions: Drug: Control Group Chirocaine
Drug: Group Fentanyl
Drug: Group sufentanil
Drug: Ephedrine
Drug: Atropine sulfate
Drug: Propofol
Drug: Metoclopramide
Drug: Diphenhydramine
Drug: pethidine hydrochloride
Drug: Diclofenac sodium

First Posted Date: 2013-05-21

Last Posted Date: 2013-05-21

Lead Sponsor: Baskent University

Target Recruit Count: 93

Registration Number: NCT01858090

Locations: 🇹🇷
Baskent University School of Medicine Adana Teaching and Research Hospital, Adana, Turkey

Compared Efficacy and Tolerance of Two Vasopressors Used to Treat Preoperative Hypotension During Carotid Surgery

Phase 4

Completed

Conditions: Endovascular Carotid Surgery
Preoperative Hypotension

Interventions: Drug: ephedrine and phenylephrine

First Posted Date: 2013-02-18

Last Posted Date: 2018-09-24

Lead Sponsor: University Hospital, Clermont-Ferrand

Target Recruit Count: 80

Registration Number: NCT01794273

Locations: 🇫🇷
CHU Clermont-Ferrand, Clermont-Ferrand, France

Treatment of Low Metabolic Rate Following Bariatric Surgery

Not Applicable

Completed

Conditions: Morbid Obesity

Interventions: Drug: Ephedrine sulfate with caffeine
Drug: cellulose

First Posted Date: 2012-05-11

Last Posted Date: 2015-09-24

Lead Sponsor: Oregon Weight Loss Surgery, LLC

Target Recruit Count: 218

Registration Number: NCT01596907

Locations: 🇺🇸
Oregon Weight Loss Surgery, LLC, Beaverton, Oregon, United States
🇺🇸
Oregon Weight Loss Surgery, Portland, Oregon, United States

The Oxygenation of the Brain During Caesarean Section

Phase 4

Completed

Conditions: Complications; Cesarean Section

Interventions: Drug: Ephedrine
Drug: Phenylephrine

First Posted Date: 2012-01-13

Last Posted Date: 2012-08-07

Lead Sponsor: Naestved Hospital

Target Recruit Count: 24

Registration Number: NCT01509521

Locations: 🇩🇰
Naestved Hospital, Naestved, Denmark

Safety Study in Adolescent and Adult Patients With Asthma

Phase 3

Completed

Conditions: Asthma

Interventions: Drug: Placebo
Drug: Epinephrine inhalation
Drug: Primatene Mist

First Posted Date: 2011-11-22

Last Posted Date: 2017-02-13

Lead Sponsor: Amphastar Pharmaceuticals, Inc.

Target Recruit Count: 208

Registration Number: NCT01476904

Locations: 🇺🇸
Amphastar Site 0006, Costa Mesa, California, United States
🇺🇸
Amphastar Site 0004, Orange, California, United States
🇺🇸
Amphastar Site 0008, Denver, Colorado, United States

and more 24 locations