Diphenhydramine

Generic Name: Diphenhydramine

Brand Names: Acetadryl, Advil PM, Aleve PM, Allegra Cooling Relief Anti-itch, Banophen, Benadryl, Benadryl Itch Stopping, Benadryl-D Allergy and Sinus, Calagel, Damylin With Codeine, Dimetapp Nighttime Cold & Congestion, Diphen, Diphenhist, Diphenist, Excedrin PM Triple Action, Goody's PM, Legatrin PM, Motrin PM, Nytol, Nytol Quickgels, Percogesic Reformulated Jan 2011, Siladryl, Simply Sleep, Sleepinal, Sominex, Triaminic Night Time Cold & Cough, Tylenol PM, Unisom, Unisom Sleep, Vanamine, Wal-dryl, Wal-som (doxylamine), Zzzquil

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₁NO

CAS Number: 58-73-1

Unique Ingredient Identifier: 8GTS82S83M

Background: Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes . However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties . As histamine receptors exist both ...

Indication: Diphenhydramine is a first-generation histamine H1 receptor antagonist (H1 antihistamine) that is widely available as a non-prescription, over-the-counter (OTC) medication. As an OTC medication, diphenhydramine is typically formulated as tablets and creams indicated for use in treating sneezing, runny nose, itchy/watery eyes, itching of nose or throat, insom...

Associated Conditions: Allergic Reaction, Allergic Rhinitis (AR), Allergic cough, Allergy to Tree Pollen, Anaphylaxis, Angioedema, Common Cold, Conjunctival irritation, Cough, Cough Variant Asthma, Cough caused by Common Cold, Eye allergy, Fever, Insect Bites, Insect Stings, Insomnia, Irritative cough, Itching of the nose, Itching of the throat, Motion Sickness, Nasal Congestion, Oral Mucositis, Pain, Parkinsonian Syndromes, Productive cough, Pruritus, Rash, Rhinorrhoea, Sinus Congestion, Sinus headache, Skin Irritation, Sneezing, Sunburn, Symptoms of Acute Bronchitis Accompanied by Coughing, Upper respiratory tract hypersensitivity reaction, site unspecified, Urticaria, Cold or flu syndrome, Dermatographism, Dry cough, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Expectorant

Clinical Trials

Treating Benign Paroxysmal Positional Vertigo (BPPV) in ED Patients

Not Applicable

Completed

Conditions: Benign Paroxysmal Positional Vertigo

Interventions: Other: Epley Maneuver
Drug: Meclizine
Drug: Lorazepam
Drug: Diphenhydramine
Drug: Ondansetron

First Posted Date: 2008-03-24

Last Posted Date: 2018-04-03

Lead Sponsor: Lehigh Valley Hospital

Target Recruit Count: 26

Registration Number: NCT00641797

Locations: 🇺🇸
Lehigh Valley Hospital, Allentown, Pennsylvania, United States

Lumbar Stenosis Outcomes Research (LUSTOR)

Phase 4

Completed

Conditions: Lumbar Spinal Stenosis

Interventions: Drug: Pregabalin
Drug: Diphenhydramine

First Posted Date: 2008-03-19

Last Posted Date: 2016-06-20

Lead Sponsor: University of Rochester

Target Recruit Count: 29

Registration Number: NCT00638443

Locations: 🇺🇸
2180 South Clinton Avenue, Rochester, New York, United States

Preoperative Gabapentin for Acute and Chronic Post-thoracotomy Analgesia

Not Applicable

Completed

Conditions: Pain

Interventions: Drug: Diphenhydramine
Drug: Gabapentin

First Posted Date: 2008-01-08

Last Posted Date: 2016-05-04

Lead Sponsor: Michelle Kinney

Target Recruit Count: 146

Registration Number: NCT00588159

Locations: 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States

Papillary Serous Carcinoma of the Endometrium

Phase 2

Completed

Conditions: Endometrial Cancer

Interventions: Drug: Paclitaxel
Radiation: Pelvic Radiation
Drug: Dexamethasone
Drug: Cimetidine
Drug: Diphenhydramine

First Posted Date: 2007-08-13

Last Posted Date: 2014-07-03

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 30

Registration Number: NCT00515073

Locations: 🇺🇸
M. D. Anderson Cancer Center - Orlando, Orlando, Florida, United States
🇺🇸
UT MD Anderson Cancer Center, Houston, Texas, United States

Pain Study to See if Ultram ER Will Provide Relief to Subjects Whose Pain is Not Well Controlled by Narcotics

Terminated

Conditions: Chronic Pain

Interventions: Drug: Tramadol Extended Release Oral Capsule
Drug: Benadryl

First Posted Date: 2007-07-23

Last Posted Date: 2020-07-22

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 7

Registration Number: NCT00505531

Locations: 🇺🇸
MGH Center for Translational Pain Research, Boston, Massachusetts, United States

Phase 2 Study of Bexxar in Relapsed/Refractory DLCL

Phase 2

Completed

Conditions: Lymphoma

Interventions: Drug: Bexxar
Drug: Acetaminophen
Drug: Diphenhydramine
Drug: Potassium Iodide (KI)

First Posted Date: 2007-06-22

Last Posted Date: 2017-03-30

Lead Sponsor: Susan Knox

Target Recruit Count: 9

Registration Number: NCT00490009

Locations: 🇺🇸
Stanford University School of Medicine, Stanford, California, United States

Phase 2 Poor Risk DLBCL of TLI and ATG Followed by Matched Allogeneic HT as Consolidation to Autologous HCT

Phase 2

Terminated

Conditions: Lymphoma, B-cell
Lymphoma, Non-Hodgkin
Diffuse Large B-cell Lymphoma (DLBCL)
Malignant Lymphoma, Non-Hodgkin

Interventions: Procedure: Autologous hematopoietic stem cell transplantation (auto-HSCT)
Procedure: Allogeneic hematopoietic stem cell transplantation (allo-HSCT)
Procedure: Total lymphoid irradiation (TLI)
Drug: Rituximab
Drug: Carmustine
Drug: Etoposide
Drug: Filgrastim
Drug: Anti-thymocyte globulin (ATG)
Drug: Cyclosporine
Drug: Mycophenolate mofetil (MMF)
Drug: Cyclophosphamide
Drug: Acetaminophen
Drug: Diphenhydramine
Drug: Hydrocortisone
Drug: Methylprednisolone

First Posted Date: 2007-06-04

Last Posted Date: 2018-05-14

Lead Sponsor: Stanford University

Target Recruit Count: 3

Registration Number: NCT00482053

Locations: 🇺🇸
Stanford University School of Medicine, Stanford, California, United States

A Study to Evaluate the Safety of Rituximab Retreatment in Subjects With Systemic Lupus Erythematosus

Phase 3

Terminated

Conditions: Lupus Erythematosus, Systemic

Interventions: Drug: Rituximab
Drug: Methylprednisolone
Drug: Acetaminophen
Drug: Diphenhydramine

First Posted Date: 2006-09-28

Last Posted Date: 2017-08-01

Lead Sponsor: Genentech, Inc.

Target Recruit Count: 31

Registration Number: NCT00381810

Locations: 🇺🇸
Arizona Arthritis & Rheumatology Research, Pllc, Paradise Valley, Arizona, United States
🇺🇸
Eden Medical Center San Leandro Hospital, San Leandro, California, United States
🇺🇸
Intermountain Research Center, Boise, Idaho, United States

and more 8 locations