Diltiazem

Generic Name: Diltiazem

Brand Names: Cardizem, Cartia, Matzim, Taztia, Tiadylt, Tiazac

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₆N_₂O_₄S

CAS Number: 42399-41-7

Unique Ingredient Identifier: EE92BBP03H

Background: Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it primarily works by inhibiting the calcium influx into cardiac and vascular smooth muscle during depolariz...

Indication: Oral

Indicated for the management of hypertension, to lower blood pressure, alone or in combination with other antihypertensive agents.

Indicated for use to improve exercise tolerance in patients with chronic stable angina.

Indicated for the management of variant angina (Prinzmetal's angina).

Intravenous
...

Associated Conditions: Angina Pectoris, Variant, Anginal Pain, Atrial Fibrillation, Atrial Flutter, Chronic Stable Angina Pectoris, Dilated Cardiomyopathies, Idiopathic, Fissure;Anal, Hypertension, Paroxysmal Supraventricular Tachycardia (PSVT), Proteinuria, Pulmonary Hypertension (PH), Leg cramps, Prophylaxis of migraine headaches

Associated Therapies: -

Clinical Trials

Effect of Diltiazem on Pharmacokinetics of BMS-914392

Phase 1

Completed

Conditions: Atrial Fibrillation

Interventions: Drug: BMS-914832
Drug: Diltiazem

First Posted Date: 2010-09-30

Last Posted Date: 2011-02-02

Lead Sponsor: Bristol-Myers Squibb

Target Recruit Count: 24

Registration Number: NCT01211808

Locations: 🇺🇸
Pra International, Lenexa, Kansas, United States

Open Label Study, Assessing the Effect of Diltiazem or Ketoconazole on the Pharmacokinetics of AZD9742 in Healthy Volunteers

Phase 1

Completed

Conditions: Pharmacokinetics

Interventions: Drug: AZD9742
Drug: Diltiazem
Drug: ketoconazole

First Posted Date: 2010-05-17

Last Posted Date: 2010-08-03

Lead Sponsor: AstraZeneca

Target Recruit Count: 28

Registration Number: NCT01124760

Locations: 🇺🇸
Research Site, Overland Park, Kansas, United States

Evaluate a Medication on How Hunger and Appetite Are Influenced by Smell

Phase 1

Terminated

Conditions: Food Intake

Interventions: Drug: Diltiazem
Other: Placebo spray

First Posted Date: 2009-11-26

Last Posted Date: 2015-12-18

Lead Sponsor: Pennington Biomedical Research Center

Target Recruit Count: 12

Registration Number: NCT01021176

Locations: 🇺🇸
Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States

Evaluation of Pain Reduction After Hemorrhoidectomy With Use of Diltiazim Ointment 2%

Phase 4

Completed

Conditions: Pain

Interventions: Drug: Diltiazem

First Posted Date: 2009-05-05

Last Posted Date: 2009-05-05

Lead Sponsor: Tehran University of Medical Sciences

Target Recruit Count: 1

Registration Number: NCT00893100

Locations: 🇮🇷
Sina General Hospital, Tehran, Iran, Islamic Republic of

Effects of Different Vasodilators on Coronary No-reflow During primAry percuTaneous Coronary intErvention in Patients With Acute Myocardial Infarction

Phase 4

Completed

Conditions: Acute Myocardial Infarction
Percutaneous Coronary Intervention

Interventions: Drug: Nitroglycerin
Drug: Diltiazem
Drug: Verapamil

First Posted Date: 2008-07-10

Last Posted Date: 2012-09-24

Lead Sponsor: Fudan University

Target Recruit Count: 102

Registration Number: NCT00712894

Locations: 🇨🇳
Zhongshan Hospital Fudan University, Shanghai, Shanghai, China

Drug Discrimination in Methadone-Maintained Humans Study 1

Phase 1

Completed

Conditions: Drug Dependence

Interventions: Drug: Cycloserine
Drug: Diltiazem
Drug: Gabapentin
Drug: Isradipine
Drug: Naloxone
Drug: Nifedipine
Drug: Placebo
Device: Saline
Drug: Verapamil

First Posted Date: 2008-01-15

Last Posted Date: 2011-03-11

Lead Sponsor: University of Arkansas

Target Recruit Count: 40

Registration Number: NCT00593463

Locations: 🇺🇸
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem

Phase 2

Completed

Conditions: Hypertrophic Cardiomyopathy

Interventions: Drug: Placebo
Drug: Diltiazem

First Posted Date: 2006-04-27

Last Posted Date: 2015-04-07

Lead Sponsor: Brigham and Women's Hospital

Target Recruit Count: 39

Registration Number: NCT00319982

Locations: 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
🇺🇸
Children's Hospital, Boston, Massachusetts, United States

The Effect of Concomitant Administration of Erythromycin and Diltiazem on CYP3A Activity in Healthy Volunteers

Phase 4

Completed

Conditions: Healthy

Interventions: Drug: Erythromycin
Drug: Diltiazem

First Posted Date: 2006-04-26

Last Posted Date: 2012-04-06

Lead Sponsor: Indiana University School of Medicine

Target Recruit Count: 7

Registration Number: NCT00318201

Locations: 🇺🇸
Indiana University Medical Center / GCRC, Indianapolis, Indiana, United States

RATe Control in Atrial Fibrillation

Phase 3

Completed

Conditions: Atrial Fibrillation

Interventions: Drug: Diltiazem
Drug: Verapamil
Drug: Metoprolol
Drug: Carvedilol

First Posted Date: 2006-04-12

Last Posted Date: 2014-05-13

Lead Sponsor: Asker & Baerum Hospital

Target Recruit Count: 80

Registration Number: NCT00313157

Locations: 🇳🇴
Vestre Viken Hospital Trust, Baerum Hospital, Rud, Akershus, Norway

Treatment of Supine Hypertension in Autonomic Failure

First Posted Date: 2005-09-22

Last Posted Date: 2017-10-13

Lead Sponsor: Vanderbilt University

Target Recruit Count: 152

Registration Number: NCT00223717

Locations: 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

© Copyright 2024. All Rights Reserved by MedPath

Home Terms & Conditions Privacy Policy