Sertraline

Generic Name
Sertraline
Brand Names
Zoloft
Drug Type
Small Molecule
Chemical Formula
C17H17Cl2N
CAS Number
79617-96-2
Unique Ingredient Identifier
QUC7NX6WMB
Background

Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as Citalopram and Fluoxetine. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects.
...

Indication

Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD). Common off-label uses for sertraline include the prevention of post stroke depression, generalized anxiety di...

Associated Conditions
Binge Eating Disorder (BED), Bulimia Nervosa, Generalized Anxiety Disorder, Major Depressive Disorder (MDD), Obsessive Compulsive Disorder (OCD), Panic Disorder, Post Traumatic Stress Disorder (PTSD), Premenstrual Dysphoric Disorder (PMDD), Social Anxiety Disorder (SAD)
Associated Therapies
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SMART Trial to Predict Anhedonia Response to Antidepressant Treatment

Phase 4
Recruiting
Conditions
Interventions
First Posted Date
2022-09-13
Last Posted Date
2023-10-04
Lead Sponsor
Mclean Hospital
Target Recruit Count
183
Registration Number
NCT05537584
Locations
🇺🇸

McLean Hospital, Belmont, Massachusetts, United States

Sertraline Effect in Uremic Pruritis

Phase 2
Completed
Conditions
Interventions
First Posted Date
2022-04-22
Last Posted Date
2022-12-14
Lead Sponsor
Alexandria University
Target Recruit Count
60
Registration Number
NCT05341843
Locations
🇪🇬

Faculty of Medicine, Aexandria University, Alexandria, Egypt

Personalized Sertraline Dosing in Patients With Depression

Recruiting
Conditions
Interventions
First Posted Date
2022-01-27
Last Posted Date
2022-11-08
Lead Sponsor
University of Belgrade
Target Recruit Count
148
Registration Number
NCT05210153
Locations
🇷🇸

Institute of Mental Health, Belgrade, Serbia

🇷🇸

Clinical Centre of Serbia, Belgrade, Serbia

🇷🇸

Military Medical Academy, Belgrade, Serbia

Virtual Reality Exposure Therapy in the Intensive Treatment of Social Anxiety Disorder

Not Applicable
Conditions
Interventions
First Posted Date
2021-07-27
Last Posted Date
2021-07-27
Lead Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Target Recruit Count
200
Registration Number
NCT04977544
Locations
🇨🇳

The Fourth Affiliated Hospital of Zhejiang University Medical College, Yiwu, Zhejiang, China

Sertraline Combined With Fluvoxamine in the Treatment of Refractory Obsessive-compulsive Disorder

Phase 4
Recruiting
Conditions
Interventions
First Posted Date
2021-07-15
Last Posted Date
2021-07-15
Lead Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Target Recruit Count
400
Registration Number
NCT04963257
Locations
🇨🇳

The Fourth Affiliated Hospital of Zhejiang University Medical College, Yiwu, Zhejiang, China

NMDA Modulation in Major Depressive Disorder

First Posted Date
2020-11-20
Last Posted Date
2024-08-26
Lead Sponsor
China Medical University Hospital
Target Recruit Count
90
Registration Number
NCT04637620
Locations
🇨🇳

Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan

A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive Disorder

First Posted Date
2020-07-17
Last Posted Date
2023-12-22
Lead Sponsor
Biogen
Target Recruit Count
440
Registration Number
NCT04476030
Locations
🇺🇸

Sage Investigational Site, Bellevue, Washington, United States

Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in Korea

First Posted Date
2020-06-24
Last Posted Date
2024-12-09
Lead Sponsor
Pfizer
Target Recruit Count
370212
Registration Number
NCT04446039
Locations
🇰🇷

Pfizer, Seoul, Korea, Republic of

Brain Hippocampal Volume Relationship With Anxious Symptoms in Major Depressive Patients

First Posted Date
2020-06-12
Last Posted Date
2020-06-12
Lead Sponsor
Hospital Universitario Dr. Jose E. Gonzalez
Target Recruit Count
30
Registration Number
NCT04430556
Locations
🇲🇽

Hospital Universitario Dr. Jose E. Gonzalez, Monterrey, Nuevo Leon, Mexico

Leveraging EEG for Antidepressant Prediction With Sertraline and Escitalopram

First Posted Date
2020-05-14
Last Posted Date
2020-10-19
Lead Sponsor
Alto Neuroscience
Registration Number
NCT04388202
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