Amoxicillin

Generic Name: Amoxicillin

Brand Names: Amoxil, Augmentin, Clavulin, Moxatag, Omeclamox, Prevpac, Talicia, Voquezna 14 Day Dualpak 20;500, Voquezna 14 Day Triplepak 20;500;500

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₁₉N_₃O_₅S

CAS Number: 26787-78-0

Unique Ingredient Identifier: 9EM05410Q9

Background: Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin.

Amoxicillin was granted FDA approval on 18 January 1974.

Indication: Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract. Amoxicillin is given with calvulanic acid to treat acute bacterial sinusitis, community acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, and urinary tract infections. Amoxicillin is given with omeprazole in the treatment of Helicobacter pylori (H. pylori) infection.

Amoxicillin is used in combination with vonoprazan and clarithromycin as co-packaged triple therapy or in combination with vonoprazan as co-packaged dual therapy to treat H. pylori infection in adults.

Associated Conditions: Acute Bacterial Sinusitis (ABS), Acute Otitis Media (AOM), Bacterial Infections, Community Acquired Pneumonia (CAP), Duodenal ulcer caused by helicobacter pylori, Genitourinary tract infection, Helicobacter Pylori Infection, Lower Respiratory Tract Infection (LRTI), Peptic Ulcer With H. Pylori Infection, Sinusitis, Skin and Subcutaneous Tissue Bacterial Infections, Urinary Tract Infection, Acute, uncomplicated Gonorrhea, Ear, nose, and throat infections

Associated Therapies: -

Clinical Trials

RCT of Efficacy of Amoxicillin Over Ampicillin on Severe Pneumonia

Not Applicable

Completed

Conditions: Treatment Failure
Lethargy
Altered Mental Status
Convulsion, Non-Epileptic
Hypoxia
Feeding; Difficult, Newborn

Interventions: Drug: Amoxicillin

First Posted Date: 2017-12-11

Last Posted Date: 2021-07-16

Lead Sponsor: International Centre for Diarrhoeal Disease Research, Bangladesh

Target Recruit Count: 308

Registration Number: NCT03369093

Locations: 🇧🇩
Dhaka Hospital, icddr,b, Dhaka, Bangladesh

Amoxicillin to Prevent Bacteria and Inflammatory Biomarkers After Intensive Periodontal Therapy

Phase 2

Conditions: Chronic Periodontitis
Bacteremia

Interventions: Drug: Amoxicillin
Other: Placebo

First Posted Date: 2017-11-27

Last Posted Date: 2017-11-27

Lead Sponsor: Universidad El Bosque, Bogotá

Target Recruit Count: 90

Registration Number: NCT03354338

Locations: 🇨🇴
Luis Antonio Noriega Frontado, Bogotá, Bogotá D.C, Colombia

Effect of Antibiotics on Gut Microbiome and Plasma Metabolome

Phase 4

Completed

Conditions: Microbial Colonization

Interventions: Drug: Vancomycin
Drug: Amoxicillin
Drug: Azithromycin

First Posted Date: 2017-09-06

Last Posted Date: 2018-04-04

Lead Sponsor: Finnish Institute for Health and Welfare

Target Recruit Count: 39

Registration Number: NCT03273296

Locations: 🇫🇮
National Institute for Health and Welfare, Helsinki, Finland

The Effect of Broccoli Sprout Extract and Probiotics for Eradication of Helicobacter Pylori

Phase 4

Conditions: Helicobacter Pylori Infection

Interventions: Dietary Supplement: Broccoli
Drug: Probiotics
Drug: Esomeprazole
Drug: Amoxicillin
Drug: Clarithromycin

First Posted Date: 2017-07-18

Last Posted Date: 2019-06-04

Lead Sponsor: Kyunghee University Medical Center

Target Recruit Count: 360

Registration Number: NCT03220542

Locations: 🇰🇷
Kyung Hee University Hospital, Seoul, Korea, Republic of

Treatment of Gardnerella Vaginalis Vaginal Colonization With Amoxicillin

Phase 2

Completed

Conditions: Vaginitis Gardnerella

Interventions: Other: Placebo
Drug: Amoxicillin

First Posted Date: 2017-07-07

Last Posted Date: 2020-08-28

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 97

Registration Number: NCT03211156

Locations: 🇺🇸
University of Alabama at Birmingham School of Medicine - Infectious Disease, Birmingham, Alabama, United States
🇺🇸
Guilford County Health Department - Greensboro - STD Clinic, Winston-Salem, North Carolina, United States