Amoxicillin

Generic Name: Amoxicillin

Brand Names: Amoxil, Augmentin, Clavulin, Moxatag, Omeclamox, Prevpac, Talicia, Voquezna 14 Day Dualpak 20;500, Voquezna 14 Day Triplepak 20;500;500

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₁₉N_₃O_₅S

CAS Number: 26787-78-0

Unique Ingredient Identifier: 9EM05410Q9

Background: Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin.

Amoxicillin was granted FDA approval on 18 January 1974.

Indication: Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract. Amoxicillin is given with calvulanic acid to treat acute bacterial sinusitis, community acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, and urinary tract infections. Amoxicillin is given with omeprazole in the treatment of Helicobacter pylori (H. pylori) infection.

Amoxicillin is used in combination with vonoprazan and clarithromycin as co-packaged triple therapy or in combination with vonoprazan as co-packaged dual therapy to treat H. pylori infection in adults.

Associated Conditions: Acute Bacterial Sinusitis (ABS), Acute Otitis Media (AOM), Bacterial Infections, Community Acquired Pneumonia (CAP), Duodenal ulcer caused by helicobacter pylori, Genitourinary tract infection, Helicobacter Pylori Infection, Lower Respiratory Tract Infection (LRTI), Peptic Ulcer With H. Pylori Infection, Sinusitis, Skin and Subcutaneous Tissue Bacterial Infections, Urinary Tract Infection, Acute, uncomplicated Gonorrhea, Ear, nose, and throat infections

Clinical Trials

Study to Evaluate the Efficacy and Safety of DWP14012-based Triple Therapy in Eradication of Helicobacter Pylori

Phase 3

Recruiting

Conditions: Helicobacter Pylori Infection
Helicobacter Pylori Infected Patients
Helicobacter Pylori Infected Subjects

Interventions: Drug: DWP14012 40mg
Drug: DWC202301 30mg
Drug: Amoxicillin 1000mg
Drug: Clarithromycin 500mg
Drug: DWC202301 30mg placebo
Drug: DWP14012 40mg placebo

First Posted Date: 2024-12-27

Last Posted Date: 2024-12-27

Lead Sponsor: Daewoong Pharmaceutical Co. LTD.

Target Recruit Count: 460

Registration Number: NCT06751121

Locations: 🇰🇷
Asan Medical Center, Seoul, Korea, Republic of

Efficacy of a 14-Day Bismuth-Containing Quadruple Therapy Guided by Drug Susceptibility Testing in Patients with Extremely Refractory Helicobacter Pylori Infection: an Exploratory Study

Not yet recruiting

Conditions: HELICOBACTER PYLORI INFECTIONS

Interventions: Drug: Bismuth
Drug: Vonoprazan
Drug: Amoxicillin
Drug: Rifabutin
Drug: Metronidazole
Drug: Other antibiotics

First Posted Date: 2024-12-12

Last Posted Date: 2024-12-19

Lead Sponsor: Xiuli Zuo

Target Recruit Count: 30

Registration Number: NCT06731023

Locations: 🇨🇳
Qilu Hospital of Shandong University, Jinan, Shandong, China

Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis

Phase 4

Recruiting

Conditions: Cystectomy
Bladder Cancer Requiring Cystectomy
Postoperative Infections
Antibiotic Prophylaxis
Ileal Conduit

Interventions: Drug: Pivmecillinam
Drug: Amoxicillin clavulanic acid
Drug: Amoxicillin
Drug: Cefuroxime
Drug: Ciprofloxacin
Drug: Linezolid
Drug: Nitrofurantoin
Drug: Trimethoprim
Drug: Sulfamethoxazole trimethoprim
Drug: Fluconazole

First Posted Date: 2024-11-29

Last Posted Date: 2025-01-09

Lead Sponsor: Rigshospitalet, Denmark

Target Recruit Count: 248

Registration Number: NCT06709196

Locations: 🇩🇰
Department of Urology, Aalborg University Hospital, Aalborg, Denmark
🇩🇰
Department of Urology, Aarhus University Hospital, Aarhus, Denmark
🇩🇰
Department of Urology, Rigshospitalet, Copenhagen, Denmark

and more 2 locations

Evaluation of the Effect of Antibiotic Prophylaxis (2g Amoxicillin One Hour Before Surgery) on an Inflammatory Factor (PGE2) in Salivary Samples After Third Molars Surgery

Phase 4

Completed

Conditions: Healthy
Third Molar Extraction Surgery
Antibiotic Prophylaxis
Amoxicillin

Interventions: Drug: Placebo
Drug: Amoxicillin

First Posted Date: 2024-09-26

Last Posted Date: 2024-09-26

Lead Sponsor: Universidad Católica San Antonio de Murcia

Target Recruit Count: 18

Registration Number: NCT06613776

Locations: 🇪🇸
UCAM dental, Clinica odontologica universitaria, Murcia, Spain

Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori.

Phase 4

Recruiting

Conditions: Helicobacter Pylori Infection
Chronic Gastritis

Interventions: Drug: esomeprazole
Drug: Bismuth
Drug: Berberine
Drug: Amoxicillin
Drug: Minocycline
Drug: clarithromycin

First Posted Date: 2024-09-19

Last Posted Date: 2024-09-19

Lead Sponsor: Xijing Hospital of Digestive Diseases

Target Recruit Count: 548

Registration Number: NCT06603688

Locations: 🇨🇳
Xijing Hosipital of Digestive Disease, Xian, Shaanxi, China

7 Days vs. 14 Days of Vonoprazan-based Triple Therapy for H. Pylori Eradication

Phase 3

Completed

Conditions: Helicobacter Pylori Infection
Adolescents
Gastritis
Vonoprazan

Interventions: Drug: Vonoprazan
Drug: Amoxicillin
Drug: Clarithromycin

First Posted Date: 2024-08-29

Last Posted Date: 2025-02-11

Lead Sponsor: Alexandria University

Target Recruit Count: 326

Registration Number: NCT06576882

Locations: 🇪🇬
Faculty of Medicine, Alexandria University., Alexandria, Egypt

High-dose Dual Therapy and Minocycline-cotaining Quadruple Therapy for Helicobacter Pylori Infection

Phase 4

Recruiting

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Vonoprazan
Drug: Bismuth Potassium Citrate
Drug: Amoxicillin
Drug: Minocycline,Metronidazole

First Posted Date: 2024-08-20

Last Posted Date: 2024-12-30

Lead Sponsor: Shanghai Jiao Tong University School of Medicine

Target Recruit Count: 200

Registration Number: NCT06561698

Locations: 🇨🇳
Hebi People's Hospital, Hebi, Henan, China
🇨🇳
Jiaozuo People's Hospital, Jiaozuo, Henan, China
🇨🇳
Luoyang central Hospital, Luoyang, Henan, China

and more 7 locations