Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

Evaluation of Motor Sparing Knee Block to Infiltration Analgesia for Pain Following Knee Arthroplasty

Phase 3

Conditions: Osteoarthritis
Knee Arthroplasty
Pain Management

Interventions: Procedure: Periarticular
Procedure: Motor free
Procedure: Motor free with dex
Drug: Ropivacaine
Drug: epinephrine
Drug: morphine
Drug: Ketorolac
Drug: Dexmedetomidine
Drug: saline

First Posted Date: 2015-09-03

Last Posted Date: 2016-11-15

Lead Sponsor: Lawson Health Research Institute

Target Recruit Count: 135

Registration Number: NCT02540070

Locations: 🇨🇦
University Hospital, London Health Sciences Centre, London, Ontario, Canada

Continues Cicatricial Perfusion of Ropivacaine Versus Placebo After Mastectomy : Rehabilitation After Treatment

Phase 3

Terminated

Conditions: Breast Cancer

Interventions: Drug: physiological saline
Drug: Ropivacaine

First Posted Date: 2015-08-17

Last Posted Date: 2018-08-13

Lead Sponsor: Institut Paoli-Calmettes

Target Recruit Count: 59

Registration Number: NCT02525211

Locations: 🇫🇷
Daniel FRANCON, Marseille, France

Comparison of Levobupivacaine, Ropivacaine and Bupivacaine in Epidural Anaesthesia

Not Applicable

Completed

Conditions: Pain Insensitivity, Congenital

Interventions: Drug: Bupivacaine
Drug: Ropivacaine
Drug: Levobupivacaine

First Posted Date: 2015-07-31

Last Posted Date: 2015-08-04

Lead Sponsor: Government Medical College, Haldwani

Target Recruit Count: 90

Registration Number: NCT02513433

Locations: 🇮🇳
Government Medical College, Haldwani, Uttarakhand, India

The Minimum Effective Volume of Ropivacaine in Ultrasound-guided Supraclavicular Block

Not Applicable

Completed

Conditions: Supraclavicular Brachial Plexus Block

Interventions: Drug: Ropivacaine

First Posted Date: 2015-07-31

Last Posted Date: 2016-02-19

Lead Sponsor: Huazhong University of Science and Technology

Target Recruit Count: 114

Registration Number: NCT02512471

Locations: 🇨🇳
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Intraoperative Transversus Abdominis Plane Block for Gynecologic Surgery (GYNTAP)

Phase 3

Withdrawn

Conditions: Postoperative Nausea and Vomiting
Postoperative Pain

Interventions: Other: Placebo
Drug: Ropivacaine
Procedure: Transversus Abdominis Plane Block

First Posted Date: 2015-07-23

Last Posted Date: 2016-05-13

Lead Sponsor: University of Mississippi Medical Center

Registration Number: NCT02506855

Locations: 🇺🇸
University of Mississippi Medical Center, Jackson, Mississippi, United States

Dorsal Penile Nerve Block for Rigid Cystoscopy in Men

Not Applicable

Completed

Conditions: Pain

Interventions: Drug: Tetracaine
Procedure: Dorsal Penile Nerve Block
Drug: Ropivacaine

First Posted Date: 2015-07-20

Last Posted Date: 2020-03-31

Lead Sponsor: West China Hospital

Target Recruit Count: 258

Registration Number: NCT02502487

Locations: 🇨🇳
West China Hospital of Sichuan University, Department of Anesthesiology, Chengdu, Sichuan, China

Trans-incisional vs Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy

Not Applicable

Completed

Conditions: Pain, Postoperative

Interventions: Procedure: Trans-incisional rectus sheath block
Procedure: Laparoscopic guided rectus sheath block
Drug: Ropivacaine

First Posted Date: 2015-07-10

Last Posted Date: 2021-01-22

Lead Sponsor: Johns Hopkins All Children's Hospital

Target Recruit Count: 48

Registration Number: NCT02494336

Locations: 🇺🇸
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida, United States

Does Perineural Dexmedetomidine Prolong Duration of a Nerve Block?

Phase 2

Completed

Conditions: Healthy

Interventions: Drug: Ropivacaine
Drug: Dexmedetomidine
Drug: Isotonic Saline

First Posted Date: 2015-07-02

Last Posted Date: 2016-01-05

Lead Sponsor: Zealand University Hospital

Target Recruit Count: 21

Registration Number: NCT02488473

Locations: 🇩🇰
Department of Anesthesiology Koege Hospital, Koege, Denmark

Fascia Iliaca Compartment Block in Acute and Chronic Pain Management in Hip Fracture Patients

Not Applicable

Completed

Conditions: Chronic Hip Pain

Interventions: Drug: Fascia iliaca compartment block
Drug: Placebo
Drug: Ropivacaine
Device: ultrasound

First Posted Date: 2015-06-24

Last Posted Date: 2019-03-12

Lead Sponsor: Asklepieion Voulas General Hospital

Target Recruit Count: 198

Registration Number: NCT02479828

Locations: 🇬🇷
Asklepieion General Hospital, Athens, Voula, Greece

Analgesic Effects of US Bilateral Rectus Sheath Block for Laparoscopic GY Surgery

Not Applicable

Completed

Conditions: Gynecologic Disease

Interventions: Procedure: Rectus sheath block
Drug: Ropivacaine
Other: Bandage
Drug: IV-PCA containing Fentanyl and Ketorolac

First Posted Date: 2015-06-19

Last Posted Date: 2015-06-19

Lead Sponsor: Ewha Womans University Mokdong Hospital

Target Recruit Count: 60

Registration Number: NCT02476799

Locations: 🇰🇷
Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of

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