Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

Sole Local Anesthetic Versus Opioid Plus Local Anesthesia in Epidural Labor Analgesia

Phase 4

Completed

Conditions: Pain

Interventions: Drug: Sole local anesthetic
Drug: Sufentanil (Opioid plus local anesthetic)
Drug: Ropivacaine

First Posted Date: 2014-01-14

Last Posted Date: 2014-02-04

Lead Sponsor: Nanjing Medical University

Target Recruit Count: 500

Registration Number: NCT02036242

Locations: 🇨🇳
Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu, China

Adductor Canal Versus Femoral Nerve Block for Analgesia Post Total Knee Arthroscopy

Not Applicable

Conditions: Knee Osteoarthritis

Interventions: Drug: Ropivacaine

First Posted Date: 2014-01-13

Last Posted Date: 2015-01-01

Lead Sponsor: Changi General Hospital

Target Recruit Count: 30

Registration Number: NCT02033603

Locations: 🇸🇬
Changi General Hospital, Singapore, Singapore

Routine Irrigation With Ropivacaine vs. Lidocaine vs. Saline of Surgical Bed in Sleeve Gastrectomy

Not Applicable

Conditions: Overweight and Obesity

Interventions: Drug: control saline
Drug: Ropivacaine
Drug: Lidocaine

First Posted Date: 2013-12-30

Last Posted Date: 2013-12-30

Lead Sponsor: The Baruch Padeh Medical Center, Poriya

Target Recruit Count: 90

Registration Number: NCT02023684

Locations: 🇮🇱
General Surgery Ward, Poriya, The Lower Galilee, Israel

Effect of Mode of Femoral Nerve Analgesia on Quadriceps Muscle Strength

Not Applicable

Conditions: Muscle Weakness

Interventions: Drug: ropivacaine

First Posted Date: 2013-12-11

Last Posted Date: 2014-07-30

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 36

Registration Number: NCT02007850

Locations: 🇰🇷
Seoul National University Bundang Hospital, Sungnam, Gyungido, Korea, Republic of

Continuous Local Anesthesia Versus Continuous Femoral Nerve Bloc After Total Knee Arthroplasty: Impact on Mean Discharge Aptitude Delay

Phase 4

Terminated

Conditions: Total Knee Arthroplasty

Interventions: Drug: Ropivacaine

First Posted Date: 2013-12-10

Last Posted Date: 2018-08-28

Lead Sponsor: University Hospital, Strasbourg, France

Target Recruit Count: 36

Registration Number: NCT02006355

Locations: 🇫🇷
CCOM-Hôpitaux Universitaires de Strasbourg, Illkirch-Graffenstaden, France

Effects of Epidural Local Anesthetics on Propofol Induction

Phase 4

Completed

Conditions: General Anesthesia
Propofol Target-controlled Infusion
Thoracic Epidural Anesthesia

Interventions: Drug: Normal Saline
Drug: Bupivacaine
Drug: Lidocaine
Drug: Ropivacaine

First Posted Date: 2013-12-04

Last Posted Date: 2014-05-16

Lead Sponsor: First Hospital of China Medical University

Target Recruit Count: 80

Registration Number: NCT02000973

Efficacy of Ultrasound-Guided Local Anesthetic Injection Into or Around the Sciatic Nerve for Lower Limb Anesthesia

Not Applicable

Completed

Conditions: Orthopedic Disorders
Foot Diseases
Injuries, Foot
Injuries, Knee
Injuries, Leg

Interventions: Procedure: Perineural Injection for Subgluteal Sciatic Nerve Block
Procedure: Intraneural Injection for Subgluteal Sciatic Nerve Block
Procedure: Femoral Nerve Block
Procedure: Patient-Controlled Postoperative Analgesia
Drug: Ropivacaine

First Posted Date: 2013-12-03

Last Posted Date: 2013-12-04

Lead Sponsor: University of Parma

Target Recruit Count: 64

Registration Number: NCT01999647

Locations: 🇮🇹
Anesthesia, Critical Care and Pain Medicine - University of Parma, Parma, PR, Italy

Preemptive Femoral & Lateral Femoral Cutaneous Nerve Blocks for THA Acute Pain

Not Applicable

Terminated

Conditions: Acetabular Labrum Tear
Internal Derangement of Hip

Interventions: Drug: Ropivacaine
Drug: Placebo

First Posted Date: 2013-11-28

Last Posted Date: 2018-10-03

Lead Sponsor: Rush University Medical Center

Target Recruit Count: 3

Registration Number: NCT01997567

Locations: 🇺🇸
Rush Oak Park Hospital, Oak Park, Illinois, United States

USG Brachial Plexus Block for Upper Extremity Surgery

Not Applicable

Completed

Conditions: Rupture of Tendon of Wrist and Hand
Injuries to the Wrist, Hand and Fingers (S60-S69)
Ganglion Cysts
Fracture at Wrist and/or Hand Level
Carpal Tunnel Syndrome

Interventions: Drug: Ropivacaine

First Posted Date: 2013-11-25

Last Posted Date: 2015-07-21

Lead Sponsor: Jens Borglum Neimann

Target Recruit Count: 120

Registration Number: NCT01993290

Locations: 🇩🇰
Department of anaesthesiology, Bispebjerg Hospital, Copenhagen, Denmark

Popliteal Sciatic Nerve Block: Intraneural or Extraneural?

Phase 4

Completed

Conditions: Hallux Valgus

Interventions: Procedure: Intraneural injection
Procedure: Extraneural injection
Drug: Ropivacaine
Device: PAJUNK SonoPlex 22G needle.

First Posted Date: 2013-11-19

Last Posted Date: 2015-02-27

Lead Sponsor: ASST Gaetano Pini-CTO

Target Recruit Count: 88

Registration Number: NCT01987128

Locations: 🇮🇹
Istituto Ortopedico G. Pini, Milan, Milano, Italy

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