Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

Minimum Effective Volume of Ropivacaine 7.5 mg/ml for the Lateral and Sagittal Infraclavicular Brachial Plexus Block

Phase 4

Completed

Conditions: Pain

First Posted Date: 2011-12-16

Last Posted Date: 2012-09-11

Lead Sponsor: University Hospital of North Norway

Target Recruit Count: 25

Registration Number: NCT01493986

Locations: 🇳🇴
University Hospital of North Norway, Tromsø, Troms, Norway

Analgesia After Total Knee Replacement Surgery

Not Applicable

Completed

Conditions: Total Knee Arthroplasty

Interventions: Drug: marcaine
Drug: naropin
Drug: sufentanil
Drug: neurontin

First Posted Date: 2011-12-09

Last Posted Date: 2015-06-08

Lead Sponsor: St. Antonius Hospital

Target Recruit Count: 81

Registration Number: NCT01489631

Locations: 🇳🇱
St. Antonius Hospital, Nieuwegein, Netherlands

Selective Block of the Axillary Nerve in Postoperative Pain Management

Not Applicable

Completed

Conditions: Pain, Postoperative

Interventions: Drug: ropivacaine
Drug: Sodium chloride

First Posted Date: 2011-11-02

Last Posted Date: 2015-03-20

Lead Sponsor: Hillerod Hospital, Denmark

Target Recruit Count: 60

Registration Number: NCT01463865

Locations: 🇩🇰
Aleris-Hamlet Hospital, Frederiksberg, Denmark

Ropivacaine Block Alone or With Perineural or Systemic Dexamethasone for Pain in Shoulder Surgery

Phase 4

Completed

Conditions: Shoulder Injury

Interventions: Drug: Ropivacaine
Drug: Normal saline
Drug: Dexamethasone

First Posted Date: 2011-10-10

Last Posted Date: 2016-06-17

Lead Sponsor: Mayo Clinic

Target Recruit Count: 130

Registration Number: NCT01450007

Locations: 🇺🇸
Mayo Clinic in Arizona, Phoenix, Arizona, United States

The Post-Operative Pain Management of Pediatric Supracondylar Elbow Fractures

Not Applicable

Completed

Conditions: Elbow Fracture

Interventions: Drug: Oxycodone with Acetaminophen
Drug: Ropivacaine 0.20%
Drug: Bupivacaine 0.25%

First Posted Date: 2011-04-05

Last Posted Date: 2015-06-23

Lead Sponsor: University of Colorado, Denver

Target Recruit Count: 124

Registration Number: NCT01328782

Locations: 🇺🇸
The Children's Hospital, Aurora, Colorado, United States

Formulations of Liposomal Local Anesthetics

Phase 1

Completed

Conditions: Underdosing of Local Anesthetics, Initial Encounter

Interventions: Drug: Ropivacaine

First Posted Date: 2011-03-03

Last Posted Date: 2011-03-03

Lead Sponsor: University of Campinas, Brazil

Target Recruit Count: 40

Registration Number: NCT01307969

Locations: 🇧🇷
Piracicaba Dental School, Piracicaba, São Paulo, Brazil

TAP Block: Does Volume Make a Difference?

Not Applicable

Completed

Conditions: Post-operative Pain

Interventions: Drug: Ropivacaine

First Posted Date: 2011-03-02

Last Posted Date: 2013-04-24

Lead Sponsor: McMaster University

Target Recruit Count: 31

Registration Number: NCT01307215

Locations: 🇨🇦
St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada

Effectiveness of Analgesia in Total Knee Arthroplasty

Phase 4

Completed

Conditions: Pain

Interventions: Drug: morphine ,ketorolac
Drug: ropivacaine,morphine chloride,epinephrine,ketorolac
Drug: ropivacaine

First Posted Date: 2011-02-25

Last Posted Date: 2014-08-28

Lead Sponsor: Jose Antonio Bernia Gil

Target Recruit Count: 137

Registration Number: NCT01304212

Locations: 🇪🇸
Consorci Sanitari de Terrassa, Terrassa, Barcelona, Spain

Clonidine in Femoral Nerve Block Surgery in Children

Phase 2

Withdrawn

Conditions: Other Reconstructive Surgery

Interventions: Drug: Clonidine
Drug: Ropivacaine

First Posted Date: 2011-02-10

Last Posted Date: 2015-05-08

Lead Sponsor: Nationwide Children's Hospital

Registration Number: NCT01293149

Locations: 🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States

Total Hip Arthroplasty: Multiple Blocks by UltraSound

Not Applicable

Conditions: Pain, Postoperative

Interventions: Drug: Ropivacaine
Device: Ultrasound
Procedure: Peripheral nerve blockade
Procedure: Total hip arthroplasty
Drug: Saline
Drug: Bupivacaine

First Posted Date: 2011-01-14

Last Posted Date: 2015-10-23

Lead Sponsor: Bispebjerg Hospital

Target Recruit Count: 81

Registration Number: NCT01276925

Locations: 🇩🇰
Bispebjerg Hospital, Copenhagen, Denmark

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