Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

Paravertebral Analgesia Associated With Intravenous Morphine PCA After Thoracotomy

Phase 3

Completed

Conditions: Pain

Interventions: Other: nacl 0,9%
Drug: ropivacaine

First Posted Date: 2008-02-21

Last Posted Date: 2010-06-28

Lead Sponsor: University Hospital, Strasbourg, France

Target Recruit Count: 60

Registration Number: NCT00620490

Locations: 🇫🇷
Service de Chirurgie Thoracique, Hôpitaux Universitaires, Strasbourg, France

The Effects of Dexamethasone on the Duration of Sciatic Nerve Blocks

Not Applicable

Terminated

Conditions: Total Knee Arthroplasty

Interventions: Drug: Ropivacaine
Drug: Normal Saline
Drug: Dexamethasone

First Posted Date: 2008-02-15

Last Posted Date: 2014-06-11

Lead Sponsor: Loma Linda University

Target Recruit Count: 43

Registration Number: NCT00616603

Locations: 🇺🇸
Loma Linda University Medical Center, Loma Linda, California, United States

Preemptive Analgesia in Children Using Caudal Epidural Ropivacaine

Not Applicable

Terminated

Conditions: Inguinal Herniorrhaphy
Orchiopexy

Interventions: Drug: Ropivacaine

First Posted Date: 2008-02-15

Last Posted Date: 2019-04-25

Lead Sponsor: Loma Linda University

Target Recruit Count: 26

Registration Number: NCT00616577

Locations: 🇺🇸
Loma Linda University Medical Center, Loma Linda, California, United States

A Phase II/III Study of Continuous Local Anesthetic Infusion in Median Sternotomy Following Cardiac Surgery

Phase 2

Terminated

Conditions: Cardiac Surgery

Interventions: Drug: Normal saline
Drug: Ropivacaine

First Posted Date: 2008-01-07

Last Posted Date: 2015-04-07

Lead Sponsor: Mayo Clinic

Target Recruit Count: 125

Registration Number: NCT00586976

Locations: 🇺🇸
Mayo Clinic College of Medicine, Rochester, Minnesota, United States

Efficacy of the Transversus Abdominus Plane (TAP) Block for Post-Cesarean Delivery Analgesia

Not Applicable

Completed

Conditions: Pain

Interventions: Drug: saline solution
Drug: ropivacaine

First Posted Date: 2007-12-14

Last Posted Date: 2009-07-30

Lead Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Target Recruit Count: 100

Registration Number: NCT00573963

Locations: 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada

Ropivacaine Versus Ropivacaine Plus Mepivacaine for Sciatic Block

Phase 4

Completed

Conditions: Subgluteal Sciatic Block

Interventions: Drug: ropivacaine plus mepivacaine
Drug: ropivacaine

First Posted Date: 2007-12-05

Last Posted Date: 2009-01-28

Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Target Recruit Count: 30

Registration Number: NCT00567450

Locations: 🇫🇷
CHU d'Amiens, Pole Anesthesie Réanimation, Place Victor Pauchet, Amiens cedex, France

Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty

Phase 4

Completed

Conditions: Osteoarthritis of the Knee

Interventions: Drug: ropivacaine
Drug: adrenaline
Drug: fentanyl
Drug: ketorolac
Drug: bupivacaine
Drug: morphine

First Posted Date: 2007-11-22

Last Posted Date: 2011-08-08

Lead Sponsor: Asker & Baerum Hospital

Target Recruit Count: 102

Registration Number: NCT00562627

Locations: 🇳🇴
Asker and Baerum Hospital, Rud, Norway

Comparison of Ropivacaine and Levobupivacaine in High Thoracic Epidural Anesthesia

Phase 4

Completed

Conditions: Coronary Artery Bypass
Epidural Anesthesia

Interventions: Drug: Ropivacaine
Drug: Levobupivacaine

First Posted Date: 2007-11-02

Last Posted Date: 2007-11-02

Lead Sponsor: Centro Cardiologico Monzino

Target Recruit Count: 61

Registration Number: NCT00552864

Locations: 🇮🇹
Department of Anesthesia & ICU. IRCCS Centro Cardiologico Monzino, Milano, Italy

Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery

Phase 3

Completed

Conditions: Breast Cancer

Interventions: Procedure: Paravertebral Block
Drug: Propofol
Drug: Ropivacaine
Drug: Fentanyl
Drug: Midazolam

First Posted Date: 2007-10-11

Last Posted Date: 2015-04-13

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 89

Registration Number: NCT00542542

Locations: 🇺🇸
UT MD Anderson Cancer Center, Houston, Texas, United States

Postoperative Analgesia With Local Infiltration After Femoral Neck Fracture

Phase 4

Completed

Conditions: Femoral Neck Fracture

Interventions: Drug: Ropivacaine

First Posted Date: 2007-09-14

Last Posted Date: 2010-05-06

Lead Sponsor: Odense University Hospital

Target Recruit Count: 50

Registration Number: NCT00529425

Locations: 🇩🇰
Odense University Hospital, Odense, Denmark

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